DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and VHA-A3

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_568051.1	Gene:	VHA-A3 / 830063	AraportID:	AT4G39080	Length:	821	Species:	Arabidopsis thaliana

Alignment Length:	919	Identity:	288/919 - (31%)
Similarity:	440/919 - (47%)	Gaps:	149/919 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDSLHT 80
            |||.|.|.||::..|:|...:..:|..|.|||.::..|.......|:.::.:|.|:.|.:.....
plant    18 RSETMQLVQLIVPMESAHLTVSYLGDLGLVQFKDLNSEKSPFQRTYAAQIKRCGEMARKIRFFRD 82

  Fly    81 YIVQLHVNEIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRMMEHSFALN 145
            .:.:..|     |..:.:.:..:.||......|..:..|...:..:..:|....|.:||:...|.
plant    83 QMSKAGV-----PAKEMQGKENDIDLDDVEVKLGELEAELVEINANNDKLQRSYNELMEYKLVLQ 142

  Fly   146 KANKYMVS---------------DMGSELLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADK 195
            ||.::..|               ..|.:||.|.     |:|:..:........|.::.|.:..:|
plant   143 KAGEFFSSAHRSAADQQRETESQQAGEDLLESP-----LLQEEKSIDSTKQVKLGFLTGLVPREK 202

  Fly   196 FYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYH 260
            ...||.:|:|....|:.||.:.:..||.:.:.|   |:..|...::..|......|:||||..:.
plant   203 SMVFERILFRATRGNIFIRQTVIEEPVIDPNSG---EKAEKNVFVVFYSGERAKSKILKICEAFG 264

  Fly   261 VNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALKVYDL 325
            .|.|.......::...:.|:|..:..::..:......|..:|:..|....:..:.:||...:|..
plant   265 ANRYPFSEDLGRQAQMITEVSGRLSELKTTIDAGLGQRNILLQTIGDKFELWNLKVRKEKAIYHT 329

  Fly   326 MNRLRLVGGVEV-PRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNT 389
            :|.|.|    :| .:.|:||.:.|.....|::..|:.|:        :||:.:
plant   330 LNMLSL----DVTKKCLVAEGWSPVFASREIQDALQRAA--------VDSNSQ------------ 370

  Fly   390 TPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAPY 454
                :.:.||.|.              ....||||||.||||...|.::||||:|.|:|.||..:
plant   371 ----VGSIFQVLR--------------TKESPPTYFRTNKFTSAIQEIVDAYGVAKYQEANPGVF 417

  Fly   455 TIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGV 519
            ||:||||||||||||.||||.::|.:..:|.|.:::...::     .:|:.:.:.|||:||:|.:
plant   418 TIVTFPFLFAVMFGDWGHGICILLATMYLILKEKKLASQKL-----GDIMEMAFGGRYVILMMSL 477

  Fly   520 FSVYMGLVYNIVMAKGFNLFG-SSWSCR---YNETT------VYDPAFHVTLDSSHPHFYSGHPY 574
            ||:|.||:||...:..|.||. |::.||   .:|.|      |.|                  .|
plant   478 FSIYTGLIYNEFFSIPFPLFAPSAYDCRDVSCSEATTIGLIKVRD------------------TY 524

  Fly   575 PLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIF 639
            |.|:||||. ..:..:...|||||||:|:||:|||..|:.::..|........::....||||||
plant   525 PFGLDPVWH-GSRSELPFLNSLKMKMSILLGVSQMNLGIIMSYFNARFFKSSVNIWFQFIPQMIF 588

  Fly   640 MLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMI 704
            :..|||||..||..||.:  |.:...|:         ..|.|.|...::..||   .::|:::.:
plant   589 LNSLFGYLSVLIIIKWCT--GSQADLYH---------VMIYMFLSPMDELGEN---QLFPHQKTL 639

  Fly   705 EFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNS---E 766
            :..|:.:|..::|.:|..||..|     |.|.|     .|.:.|..|.:..|      |.|   |
plant   640 QLVLLFLALVSVPCMLLPKPFIL-----KKQHE-----ARHQGQAYAPLDET------DESLHVE 688

  Fly   767 TSRQKSVDNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWH--MVLT 829
            |:...| ...||.|.|||::|..|||||.|||:||:||||||||||||||.:||.|.:.  ::|.
plant   689 TNGGGS-HGHEEFEFSEIFVHQLIHTIEFVLGAVSNTASYLRLWALSLAHSELSSVFYEKVLLLA 752

  Fly   830 KGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKA 894
            .|:.|.|.|..||.|.:   ||    ||.:|::||.||||||.|||||||||:||:.|.|..|..
plant   753 WGYNNPLILIVGVLVFI---FA----TVGVLLVMETLSAFLHALRLHWVEFQNKFYEGDGYKFAP 810

  Fly   895 FNFP-TSNQ 902
            |.|. |:|:
plant   811 FTFIFTANE 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	276/889 (31%)
VHA-A3	NP_568051.1	NtpI	17..814	CDD:224188	285/912 (31%)
VHA-A3	NP_568051.1	V_ATPase_I	40..813	CDD:279793	276/889 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181796at2759
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780