DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-3 and atp6v0a2a

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	XP_009303407.1	Gene:	atp6v0a2a / 561469	ZFINID:	ZDB-GENE-091113-4	Length:	848	Species:	Danio rerio

Alignment Length:	915	Identity:	320/915 - (34%)
Similarity:	492/915 - (53%)	Gaps:	112/915 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||:|.|.||.|.:.:|:.|:.|:|..|.|:|.::..........:..::.:|.|:.||:..
Zfish     3 SGFRSEEMCLAQLFLQSGSAYACISELGEMGLVEFRDLNPSVSSFQRRFVSEIKRCEEMERILGY 67

  Fly    78 LHTYI--VQLHVNEIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRMMEH 140
            |...|  ..:.|.|...|.|    ....|::.:..:.|:|:.||.|.|.::..:|......:||:
Zfish    68 LLREIRKANIAVPEAEVPPV----APAPKNVLEIMEQLQRLEVELSEVAKNKEKLQRNLLELMEY 128

  Fly   141 SFALNKANKYMVSDMGSELL---YSE------STVIGLVQDATTTSGAYPAHLNYMIGCIRADKF 196
            :..|.....::.|....|.|   |.|      .:|.|     .|:.....|.|.::.|.|:..|.
Zfish   129 THMLRITRSFVHSRSRHEALGPQYEEFPSLETESVTG-----CTSMQRLGAKLGFVSGLIQRVKV 188

  Fly   197 YSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMAS-STMIWPKVLKICAHYH 260
            .:||.:|:|:|....|:.::|:...:.:...|    .:||..:.:::. ...|..||.|||..||
Zfish   189 EAFERMLWRVCKGYTILSYAEVDESLADLDTG----EIRKNVVFLISFWGDQIGQKVQKICDCYH 249

  Fly   261 VNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDL--FIIRVNLRKALKVY 323
            .:||..|.:..:|.|.:..|...|.::..||...|...:|:|..|....  ::::|...||  :|
Zfish   250 CHIYPHPETDEERADVMDSLRTRIQDLHNVLHRTEDYLKQVLHKASESAQSWVLQVKKMKA--IY 312

  Fly   324 DLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPN 388
            .::|   |.......:.|:|||:.|.||:..:...|...|| .|.|               |:|:
Zfish   313 HILN---LCSFDVTNKCLIAEVWCPVSDLANLRRALEEGSR-KGDA---------------TVPS 358

  Fly   389 TTPYPIEADFQPLEDMSAGAILLKKNRL-VNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPA 452
            ..                       ||: .:..|||..|.||||.|||::::|||:.||:|::||
Zfish   359 FV-----------------------NRIPSSDTPPTLLRSNKFTSGFQSIVEAYGVGDYREVSPA 400

  Fly   453 PYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLM 517
            |:|||||||||||||||||||.:|.||:..|:.    .||........|||...|:.||||||:|
Zfish   401 PFTIITFPFLFAVMFGDLGHGSVLTLFALWMVL----TEKDHTRRRPGNEIRMTLFDGRYIILMM 461

  Fly   518 GVFSVYMGLVYNIVMAKGFNLFGSSWSCR--------YNETTVYDPAFHVTLDSSHPHFYSGHPY 574
            |:||:|.||:||...:|..|:|||:||.:        .|||...:  ..:||:.:....:|| ||
Zfish   462 GLFSIYTGLIYNDCFSKSLNIFGSAWSVKAMFTEQEWTNETLRSN--MLLTLNPNVSGVFSG-PY 523

  Fly   575 PLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIF 639
            |||:||:|.: ..:.:|..||.||||::::|:..|.||:.|:..|.:...:|..:.|:.:|:::|
Zfish   524 PLGIDPIWNM-AVNRLTFLNSYKMKMSVIIGVVHMSFGVVLSVFNHLHFRQKYKIYLLFLPELLF 587

  Fly   640 MLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMI 704
            :|||||||.|:|||||::|...     ::..|||:||.||||.||:     .|....:||.:..:
Zfish   588 LLCLFGYLAFMIFYKWLAYTAR-----DSQLAPSILIHFINMFLMQ-----ANATSPLYPGQMGL 642

  Fly   705 EFALVGIAFCTIPILLAGKPIYLM---RRRRKMQQER----ERDFKRMRRQTIAEMRSTMRYTDD 762
            :..||.:|..::|:||.|||:||.   ...:.:...|    ...::|:||.:..::..::.:.::
Zfish   643 QVFLVVVALLSVPVLLLGKPLYLYWLHHGGKSLGIHRVCLCSCGYERVRRVSEEDLSPSVVHDEE 707

  Fly   763 DNSETSRQKSVDNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMV 827
            :....|     ...:|.:..::::|..|||||..||.:|:||||||||||||||.|||:|||.||
Zfish   708 EGLSES-----GGPQEFDFGDVFLHQAIHTIEYSLGCISNTASYLRLWALSLAHAQLSEVLWAMV 767

  Fly   828 LTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESF 892
            :..|...:..|  ||..|:..|..:|:||::||::|||||||||.|||||||||:||:.|||..|
Zfish   768 MRLGLRISSRL--GVIFLVPVFSVFAVLTISILLVMEGLSAFLHALRLHWVEFQNKFYSGAGVKF 830

  Fly   893 KAFNF 897
            ..|:|
Zfish   831 APFDF 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	307/888 (35%)
atp6v0a2a	XP_009303407.1	NtpI	26..833	CDD:224188	306/888 (34%)
atp6v0a2a	XP_009303407.1	V_ATPase_I	28..835	CDD:279793	307/888 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750