Protein Alignment Vha100-3 and atp6v0a2b

DIOPT Version :10

• Sequence 1: NP_725837.1
• Gene: Vha100-3 / 246543
• FlyBaseID: FBgn0028669
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_001116219.1
• Gene: atp6v0a2b / 561117
• ZFINID: ZDB-GENE-060526-4
• Length: 849
• Species: Danio rerio
• Alignment Length: 940
• Identity: 329/940 - (35%)
• Similarity: 489/940 - (52%)
• Gaps: 161/940 - (17%)

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||:|.|.||.|.:.:|:||:.|:|..|.|:|.::..........:..::.:|.|:.||:..
Zfish     3 SLFRSEEMCLAQLFLQSGSAYDCISELGELGLVEFRDLNPSVNSFQRKFVNEIKRCEEMERILGY 67

  Fly    78 LHTYIVQLHVNEIFYPDVDRENRLKE----------KDLAKYSDSLKRIHVEASAVTEHYYRLDS 132
            |        :.||...|:.    |.|          |.:....:.|:|:.:|...||.:..:|..
Zfish    68 L--------LREIKKEDIP----LPEGEVNPAAPLPKHVMVIMEQLQRLELELGEVTRNKEKLQK 120

  Fly   133 RRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYP---------------- 181
            ....:.|::..|.....::  ..|:|              ..:|.|.|.
Zfish   121 NLLELTEYTHMLRITRNFV--HRGTE--------------RESTQGQYEEFPFLEKEPMMDYTSM 169

  Fly   182 ----AHLNYMIGCIRADKFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMM 242
                |.|.::.|.|::.|..:||.:|:|:|....|:.:||:...:.:...|   |..|....|:.
Zfish   170 QRLGAKLGFISGLIQSVKIEAFERMLWRVCKGYTILSYSEVDELLDDPDSG---EPTRSVVFLIS 231

  Fly   243 ASSTMIWPKVLKICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGR 307
            .....|..||.|||..||.::|..|:|..:|.|.|:.|...|.::..||...|...||:|..|..
Zfish   232 YWGEQIGQKVKKICDCYHCHLYPYPNSNEERTDVVEGLRTRIQDLHTVLHRTEDYLRQVLIKASE 296

  Fly   308 DLFIIRVNLRKALKVYDLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGG---- 368
            .::|..:.::|...:|.::|   |.......:.|:|||:.|.:|:|.:...|.:.||.||.
Zfish   297 SVYIWVIQVKKMKAIYHILN---LCSFDVTNKCLIAEVWCPVNDLPALRRALEDGSRKSGATVPS 358

  Fly   369 -ADNIDSSDEDEMNDMKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTR 432
             .:.|.|||                                           .|||..|.||||.
Zfish   359 FVNRIPSSD-------------------------------------------TPPTLIRTNKFTS 380

  Fly   433 GFQNLIDAYGMADYKELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIW--KHREIEKYQI 495
            ||||::||||::.|:|:|||||||||||||||||||||||||::.||:..|:.  ..|:::|
Zfish   381 GFQNIVDAYGVSSYREVNPAPYTIITFPFLFAVMFGDLGHGIIMALFALWMVLYENDRKLKK--- 442

  Fly   496 NATSENEILNILYAGRYIILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCR-------YNETTVY 553
               :.|||.||.:.||||||||||||||.||:||...:|..|:|||.|:..       :..:||.
Zfish   443 ---TRNEIWNIFFEGRYIILLMGVFSVYTGLIYNDCFSKSLNIFGSGWNVSAMFENGDWTLSTVN 504

  Fly   554 DPAFHVTLDSSHPHFYSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAA 618
            .... :.||.:....:.| |||||:||:|.: ..:.:|..||.||||::::||..|.||:.|...
Zfish   505 SNKL-LALDPNITGVFKG-PYPLGIDPIWNL-ASNRLTFLNSYKMKMSVIVGIIHMTFGVVLGIF 566

  Fly   619 NCVLMNRKADLILVVIPQMIFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMML 683
            |.:...|..::.|:.:|:::|:|||||||||:|.|||:.:     ...::..|||:||.||||.|
Zfish   567 NHLHFRRTINVYLIFLPELLFLLCLFGYLVFMIIYKWLFF-----TVRDSQTAPSILIHFINMFL 626

  Fly   684 MKKED--PVENCLDYMYPNERMIEFALVGIAFCTIPILLAGKPIYLM-----RRRRKMQQERERD 741
            |..:.  |       :||.:...:..||.:|..::|:||.|||:|:.     |.|..|.    |.
Zfish   627 MMGDSGRP-------LYPGQAGFQVFLVIVAVFSVPVLLFGKPLYIYWQHKGRDRLSMY----RG 680

  Fly   742 FKRMRRQTIAEMRSTMRYTDD---DNSETSRQKSVDNE-EEHEMSEIWIHSGIHTIETVLGSVSH 802
            ::|:||.:..|:  ::.:|.|   .:|..|...|.|:: ||.:..:::::..|||||..||.:|:
Zfish   681 YQRVRRSSEEEL--SLLHTHDLEEGSSLDSHSSSSDSQSEEPDFPDLFLNQSIHTIEYCLGCISN 743

  Fly   803 TASYLRLWALSLAHDQLSDVLWHMVLTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLS 867
            ||||||||||||||.|||:|||.||:.  .|..:....|:.:|:..|..:|:|||:||::|||||
Zfish   744 TASYLRLWALSLAHAQLSEVLWEMVMR--VALHVDTSVGIVLLVPVFGLFAVLTVSILLVMEGLS 806

  Fly   868 AFLHTLRLHWVEFQSKFFGGAGESFKAFNF 897
            ||||.|||||||||:||:.|.|..|..|.|
Zfish   807 AFLHALRLHWVEFQNKFYSGVGVKFIPFAF 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:460232	315/913 (35%)
atp6v0a2b	NP_001116219.1	V_ATPase_I	27..836	CDD:460232	315/914 (34%)