Protein Alignment Vha100-3 and tcirg1

DIOPT Version :10

• Sequence 1: NP_725837.1
• Gene: Vha100-3 / 246543
• FlyBaseID: FBgn0028669
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: XP_012809053.3
• Gene: tcirg1 / 549603
• XenbaseID: XB-GENE-5721917
• Length: 865
• Species: Xenopus tropicalis
• Alignment Length: 925
• Identity: 304/925 - (32%)
• Similarity: 479/925 - (51%)
• Gaps: 138/925 - (14%)

  Fly    10 KVKSFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRI 74
            |:.|.||.|:|.|.||.|.:.:.:.|:..:|..|.|:|.::..........|..::.:|.|:
 Frog    42 KMGSLFRGEEMCLAQLFLQSGSEYQCVSALGELGLVEFRDLNQNVNSFQRRYVSEIRRCDEM--- 103

  Fly    75 VDSLHTYI--------VQLHVNEIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLD 131
             ::..:|:        ||:..:|:..|      ....:|..:..:..:::..|...|:::...|.
 Frog   104 -ETTFSYLERELRKAGVQVPESEMSPP------APLPRDAIRMQEESEQLAKELREVSQNRQTLQ 161

  Fly   132 SRRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYPAHLN-------YMIG 189
            .|...::|::..|.::.::....:.||..:.:.:....:.|        ||.:|       :|.|
 Frog   162 ERLRELLEYANILRESQRFTGPLLESEAQWKDRSEDDPLLD--------PAVVNKQDLRVSFMAG 218

  Fly   190 CIRADKFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLK 254
            .|...:..|||.||:|.|...||:.|.||..|:.:...|   |.|.:...|:......|..|:.|
 Frog   219 VIHPWRMNSFERLLWRACRGYLIVNFVEMSEPMEDLVTG---ESVTQIIFLISYWGEKIGEKIKK 280

  Fly   255 ICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKA 319
            |...:|.:||......:.|.:.::.|..:|.:::|||.:.|....|:|..|...|...||::||.
 Frog   281 IANCFHCHIYPYADDETSRLETLRNLLVQIQDMQKVLLQTEGYLSQVLSRAASALHHWRVSVRKM 345

  Fly   320 LKVYDLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMK 384
            ..:|.::|...:     ..|.|:.||:.|..|:|.::..|..||..|||..
 Frog   346 KHIYLILNLCSV-----RERCLIGEVWCPVVDLPLLQSALTRASESSGGGG-------------- 391

  Fly   385 TMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKEL 449
               .:..:.|...|.                     |||..|.||||.|||.::||||:|.|:|:
 Frog   392 ---ESFCHRIPCAFS---------------------PPTLIRTNKFTSGFQGIVDAYGVATYQEV 432

  Fly   450 NPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYII 514
            |||.::||||||||||||||:|||.::.||:..::....:.:..:    ||:||.::.:.|||:|
 Frog   433 NPAIFSIITFPFLFAVMFGDVGHGAIMFLFALWLVLGENDPKLRR----SEDEIFSMCFGGRYLI 493

  Fly   515 LLMGVFSVYMGLVYNIVMAKGFNLFGSSWS----CRYNETT-----VYDPAFHVTLDSSHPHFYS 570
            ||||..|||.|.|||...::...:|.|.||    .|.|..|     ...|   :.|:.:....::
 Frog   494 LLMGALSVYTGFVYNECFSRPAVIFNSGWSVASMARANNWTSDSINKLPP---IPLNPNITGVFT 555

  Fly   571 GHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIP 635
            . |||.|:||:|:: ..:.:|..||.||||:::||:..|.||:.|:..|.|...:...:.|:.:|
 Frog   556 A-PYPFGIDPIWSL-AVNRLTFLNSFKMKMSVILGVCHMAFGVCLSVFNFVHFRQIYRIFLITLP 618

  Fly   636 QMIFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPN 700
            :::|:|||||||||::.|||:.....     :|..|||:||.||:|.|. .::|....|   |..
 Frog   619 ELLFLLCLFGYLVFMVVYKWIVLTAE-----DAEWAPSILIHFIDMFLF-TQNPGNRDL---YQG 674

  Fly   701 ERMIEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNS 765
            :::::..||.:|...||:||.|.||.|:     :|...::|.....|.::            :|.
 Frog   675 QQVVQTVLVIVAILCIPVLLLGDPICLL-----IQHRSKKDSSHQNRCSL------------NNG 722

  Fly   766 ETSRQKSVDNE-----------EEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQL 819
            :  |:..:::|           |:.:.:|:::|..|||||..||.:|:||||||||||||||.||
 Frog   723 D--REALLEDEITVPTGHGHGSEKFDTAEVFMHQMIHTIEYCLGCISNTASYLRLWALSLAHAQL 785

  Fly   820 SDVLWHMVLTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKF 884
            |:|||:||:..||:. |.|.:|: ||:..|..:|:||||||::|||||||||.|||||||||:||
 Frog   786 SEVLWNMVIRIGFSK-LSLTWGI-VLVPIFAFFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKF 848

  Fly   885 FGGAGESFKAFNFPT 899
            :.|.|..|..|.|.|
 Frog   849 YSGEGYKFFPFCFET 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:460232	291/893 (33%)
tcirg1	XP_012809053.3	V_ATPase_I	69..861	CDD:460232	291/894 (33%)