DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and ATP6V0A1

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001365459.1	Gene:	ATP6V0A1 / 535	HGNCID:	865	Length:	903	Species:	Homo sapiens

Alignment Length:	971	Identity:	329/971 - (33%)
Similarity:	505/971 - (52%)	Gaps:	170/971 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYEL---LRIVD 76
            ||||:|.|.||.|.:|.|:.|:.|:|..|.|||.::..:..:....:..:|.:|.|:   ||.|:
Human     5 FRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVE 69

  Fly    77 ----SLHTYIVQLHVN-EIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNR 136
                ..:..|:....| |:.:|   |:....|.:..|..:.||.|:....|:..::..|
Human    70 KEIRKANIPIMDTGENPEVPFP---RDMIDLEANFEKIENELKEINTNQEALKRNFLEL------ 125

  Fly   137 MMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADKFYSFEL 201
             .|..|.|.|..::. .:|....|..||:  .|::.:....|. |..|.::.|.|..::..:||.
Human   126 -TELKFILRKTQQFF-DEMADPDLLEESS--SLLEPSEMGRGT-PLRLGFVAGVINRERIPTFER 185

  Fly   202 LLYRLCSFNLIIRFSEMPSPV-----YEYH---------------------------------YG 228
            :|:|:|..|:.:|.:|:.:|:     .|.|                                 :|
Human   186 MLWRVCRGNVFLRQAEIENPLEDPVTVESHSVVQARVQWRDLGSPQPPLPGFKRFSCLSLPSSWG 250

  Fly   229 YKPERVRKFAILMMASSTMIWPKVLKICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKE 293
            .:.:.|.|...::......:..:|.|||..:..::|.||.:..:|::....::..|.:::.||.:
Human   251 LQGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQ 315

  Fly   294 AELMRRQILEVAGRDLFIIRVNLRKALKVYDLMNRLRLVGGVEV-PRYLLAEVYIPSSDVPEVEV 357
            .|..|:::|:.|.:::.:..:.:||...:|..:|    :..::| .:.|:|||:.|.:|:..::.
Human   316 TEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLN----LCNIDVTQKCLIAEVWCPVTDLDSIQF 376

  Fly   358 ILRNASRISGGADNIDSSDEDEMNDMKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRL-VNHMP 421
            .||..:..||                    :|.|                :||   ||: .|..|
Human   377 ALRRGTEHSG--------------------STVP----------------SIL---NRMQTNQTP 402

  Fly   422 PTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWK 486
            |||.:.||||.||||::||||:..|:|:||||||||||||||||||||.|||||:.||:..|:.:
Human   403 PTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLR 467

  Fly   487 HREIEKYQINATSENEILNILYAGRYIILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCR----Y 547
            ...|    ::..:|||:.:.:::||||||||||||:|.||:||...:|..|:||||||.|    |
Human   468 ESRI----LSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTY 528

  Fly   548 N---ETTVYDPAFHVTLDSSHPHFYSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQM 609
            |   ||...:|.  :.|:.:.|..:.| |||.|:||:|.: ..:.:|..||.||||:::|||..|
Human   529 NWTEETLRGNPV--LQLNPALPGVFGG-PYPFGIDPIWNI-ATNKLTFLNSFKMKMSVILGIIHM 589

  Fly   610 MFGLGLAAANCVLMNRKADLILVVIPQMIFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSV 674
            :||:.|:..|.:...:..::....||::|||..||||||.||||||.:|..|     .:..|||:
Human   590 LFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAH-----TSENAPSL 649

  Fly   675 LITFINMMLMKKEDPVENCLDYMYPNERMIEFALVGIAFCTIPILLAGKPIYLMRR--RRK---- 733
            ||.||||.|....   |:....:|..::.|:..||.:|...:|.:|..||:.|.|:  |||
Human   650 LIHFINMFLFSYP---ESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLEG 711

  Fly   734 --MQQERERDFKRMRRQTIAEMRSTMRY---------TDDD-----------NSETSRQKSVDNE 776
              ::.....:..:...:..|....|:.:         |::|           :||.:.:.|.|
Human   712 QPVEAPVSPNPSQQGLEAAAAATGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDADEPSED-- 774

  Fly   777 EEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVL-----TKGFANTL 836
            |..:..:..:|..|||||..||.:|:||||||||||||||.|||:|||.||:     .|..|..|
Human   775 EVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGL 839

  Fly   837 PLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFNF 897
            .|::       .|.|:|.||||||::|||||||||.|||||||||:||:.|.|..|..|:|
Human   840 VLFF-------FFTAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGTGFKFLPFSF 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	316/946 (33%)
ATP6V0A1	NP_001365459.1	V_ATPase_I	27..893	CDD:396194	316/947 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.730