Protein Alignment Vha100-3 and ATP6V0A4

DIOPT Version :9

• Sequence 1: NP_725837.1
• Gene: Vha100-3 / 246543
• FlyBaseID: FBgn0028669
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_065683.2
• Gene: ATP6V0A4 / 50617
• HGNCID: 866
• Length: 840
• Species: Homo sapiens
• Alignment Length: 924
• Identity: 323/924 - (34%)
• Similarity: 486/924 - (52%)
• Gaps: 135/924 - (14%)

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||:|.|.||.|..|.|:.|:.|:|..|.|||.::..........:..:|.:|..|.||:..
Human     3 SVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERILRF 67

  Fly    78 L-----HTYIVQLHVNEIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRM 137
            |     :..:|||.......| :.||....|..|.|....|:..:....|:.:.:..|
Human    68 LEDEMQNEIVVQLLEKSPLTP-LPREMITLETVLEKLEGELQEANQNQQALKQSFLEL------- 124

  Fly   138 MEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATT--TSG-----AYPAH----LNYMIGCI 191
            .|..:.|.|...:.            .|...|..|..|  |||     |.||:    |.::.|.|
Human   125 TELKYLLKKTQDFF------------ETETNLADDFFTEDTSGLLELKAVPAYMTGKLGFIAGVI 177

  Fly   192 RADKFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKIC 256
            ..::..|||.||:|:|..|:.::||||.:|:.:   ....|.::|...::......:..|:.|||
Human   178 NRERMASFERLLWRICRGNVYLKFSEMDAPLED---PVTKEEIQKNIFIIFYQGEQLRQKIKKIC 239

  Fly   257 AHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALK 321
            ..:...:|.||..|.:|.:.::.::..:.::..|:.:.|..|:::|:.|..:.....:.::|...
Human   240 DGFRATVYPCPEPAVERREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKA 304

  Fly   322 VYDLMNRLRLVGGVEVPRY-LLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKT 385
            ||.::|    :..::|.:. ::||::.|.:|...::..|.....:||
Human   305 VYHILN----MCNIDVTQQCVIAEIWFPVADATRIKRALEQGMELSG------------------ 347

  Fly   386 MPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELN 450
               ::..||....|.                 ...|||:.|.||||.||||::||||:..|:|:|
Human   348 ---SSMAPIMTTVQS-----------------KTAPPTFNRTNKFTAGFQNIVDAYGVGSYREIN 392

  Fly   451 PAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIIL 515
            |||||||||||||||||||.|||.:::|.:..||...|.:    ::..::|||.|..:.|||:||
Human   393 PAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRL----LSQKTDNEIWNTFFHGRYLIL 453

  Fly   516 LMGVFSVYMGLVYNIVMAKGFNLFGSSWSCR-------YNETTVYDPAFHVTLDSSHPHFYSGHP 573
            |||:||:|.||:||...:|..|:||||||.:       :| |.|.:.:.::.||.:.|..|.|:|
Human   454 LMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWN-THVMEESLYLQLDPAIPGVYFGNP 517

  Fly   574 YPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMI 638
            ||.|:||:|.: ..:.:|..||.||||:::|||.||:||:.|:..|.:...|..::||..||:||
Human   518 YPFGIDPIWNL-ASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIPEMI 581

  Fly   639 FMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERM 703
            |:|||||||||:|.:||..:..|.     :..|||:||.||||.|....|.....|   |.:::.
Human   582 FILCLFGYLVFMIIFKWCCFDVHV-----SQHAPSILIHFINMFLFNYSDSSNAPL---YKHQQE 638

  Fly   704 IEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETS 768
            ::...|.:|..::|.:|..||..|....||.|.:..|          .:..:|.....|.:|.:|
Human   639 VQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASR----------IQEDATENIEGDSSSPSS 693

  Fly   769 R--QKSV--------DNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVL 823
            |  |::.        |:.||....::::|..|||||..||.:|:||||||||||||||.|||:||
Human   694 RSGQRTSADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVL 758

  Fly   824 WHMVL-----TKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSK 883
            |.||:     |:|:...:    ||.::.|.|   |:||||||::|||||||||.|||||||||:|
Human   759 WTMVMNSGLQTRGWGGIV----GVFIIFAVF---AVLTVAILLIMEGLSAFLHALRLHWVEFQNK 816

  Fly   884 FFGGAGESFKAFNF 897
            |:.|.|..|..|:|
Human   817 FYVGDGYKFSPFSF 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	309/897 (34%)
ATP6V0A4	NP_065683.2	NtpI	28..831	CDD:224188	310/899 (34%)
		V_ATPase_I	28..830	CDD:279793	309/897 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..704		7/38 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.780