DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and Vha100-4

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_650720.1	Gene:	Vha100-4 / 42214	FlyBaseID:	FBgn0038613	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	911	Identity:	308/911 - (33%)
Similarity:	477/911 - (52%)	Gaps:	117/911 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLR---- 73
            |.||||.|.|.|:.|..|.|:|.:..:|..|.|||.::..:.......:..:|.:|.||.|
  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79

  Fly    74 -----------IVDSLHTYIVQLHVNEIFYPDVDRENRLKEK-----DLAKYSDSLKRIHVEASA 122
                       ::|.:..:.......||    :|.|..|::.     :||..:.:|:..::|.|.
  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREI----IDLELHLEKTETEILELAANNVNLQTSYLELSE 140

  Fly   123 VTEHYYRLDSRRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYPAHLNYM 187
            :.:...|.|...:....|:|.|||                    :|..:|...::|    ||.::
  Fly   141 MIQVLERTDQFFSDQESHNFDLNK--------------------MGTHRDPEKSNG----HLGFV 181

  Fly   188 IGCIRADKFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKV 252
            .|.|..::.|:||.:|:|:...|:.:|..::...:.:...|   ..:.|...::......:..::
  Fly   182 AGVISREREYAFERMLWRISRGNVFVRRCDVDVALTDPKTG---NVLHKSVFVVFFQGDQLQARI 243

  Fly   253 LKICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLR 317
            .|:|..:|.::|.||||.|:|::.||.:...:.:::.::.:....|..:|:.|.:.|......::
  Fly   244 RKVCTGFHAHMYPCPSSHSERQEMVKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVK 308

  Fly   318 KALKVYDLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMND 382
            |...:|..:|...:..|   .:.|:.|.::|..::..|||.|      :.|:.::.|:....:|.
  Fly   309 KMKGIYHTLNLFNVDLG---SKCLIGEGWVPKRELELVEVAL------AAGSASVGSTVPSFINV 364

  Fly   383 MKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYK 447
            :.|                          ||.      |||:||.|||||||||||||||:|.|:
  Fly   365 LDT--------------------------KKE------PPTHFRTNKFTRGFQNLIDAYGIAGYR 397

  Fly   448 ELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRY 512
            |:||..||.|||||||||||||:|||.:|.|....|:     |::.:::.....||.||.:||||
  Fly   398 EVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMV-----IDEKRLSKKRGGEIWNIFFAGRY 457

  Fly   513 IILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCRYNETTVY-DPAFHVTLDSSHPHFYSGHPYPL 576
            ||:|||:|::|.|..||.:.:|..|:||:.|...||.|||. :|...:     :|...:...||:
  Fly   458 IIMLMGLFAMYTGFHYNDIFSKSINVFGTRWVNVYNRTTVLTNPTLQL-----NPSVATRGVYPM 517

  Fly   577 GMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFML 641
            |:||:|. ...:.|...|:.|||::|:.|:..|:||:.::..|.|...:.|.:||..:||::|:|
  Fly   518 GIDPIWQ-SASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVPQVLFLL 581

  Fly   642 CLFGYLVFLIFYKWMSYGGHKPAPYNA-ACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIE 705
            .:|||:.|::||||:.|........:. .|||||||.||:|:|.|.|..:..|...|:|.::.:|
  Fly   582 LMFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVNMFPIQKNLE 646

  Fly   706 FALVGIAFCTIPILLAGKPIYLMRRRRKMQ----QERERDFKRMRRQTIAEMRSTMRYTDDDNSE 766
            ...:.:|...||.:|.|||:|:..:||...    :|.:...:::...|..|:..|      :.:|
  Fly   647 MIFLVVALLCIPWILLGKPLYIKYQRRNRPAGPVEEVDEIVEKIEVTTGKEIIIT------EVAE 705

  Fly   767 TSRQKSVDNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLTKG 831
            .........|::..|||||||..|||||.:|.::||||||||||||||||.|||:|||.|||..|
  Fly   706 AHESGGHSEEDDEPMSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVLWTMVLAMG 770

  Fly   832 FANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFN 896
            .  .:..|.|...|...|..|...|:||:||||||||||||||||||||.|||:.|.|..|..|:
  Fly   771 L--QMNGYVGAIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGNGYPFTPFS 833

  Fly   897 F 897
            |
  Fly   834 F 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	295/884 (33%)
Vha100-4	NP_650720.1	NtpI	17..836	CDD:224188	307/909 (34%)
Vha100-4	NP_650720.1	V_ATPase_I	40..834	CDD:279793	295/884 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451293
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	P	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.750