DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and tcirg1b

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_998234.1	Gene:	tcirg1b / 406342	ZFINID:	ZDB-GENE-040426-2022	Length:	822	Species:	Danio rerio

Alignment Length:	905	Identity:	308/905 - (34%)
Similarity:	476/905 - (52%)	Gaps:	113/905 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||::.|.||.|.:.:|::|:.|:|..|.|:|.::..........:..:|.:|.||.:....
Zfish     3 SLFRSEEVCLIQLFLQSGSAYNCVSELGELGIVEFRDLNPNVNAFQRKFVNEVRRCEELEKTFAF 67

  Fly    78 LHTYIVQLHVNEIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRMMEHSF 142
            |...| ...:::...|.:......:.::|....:..:|:..|...|:.:...|.|:..::.::..
Zfish    68 LEQEI-NRSLSQKLQPPIPMPPAPQPRELLTIEEESERLARELREVSRNRDSLRSQYTQLCQYRG 131

  Fly   143 ALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADKFYSFELLLYRLC 207
            .|.:.:....|.  :.|:..|.  :||.::      .....|:::.|.:...|..:||.||:|.|
Zfish   132 VLKQTHSLTASQ--APLVSFEP--MGLAEN------RQDVRLSFVAGVVHPWKVPAFERLLWRAC 186

  Fly   208 SFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHVNIYDCPSSASQ 272
            ...:|:.|.||...:...|   ..|:::....|:......|..||.|||..:|...:..|.:.::
Zfish   187 RGYIIVDFHEMEEKLEHPH---TDEQLQWTVFLISFWGDQIGQKVKKICDCFHTQTFPYPENQAE 248

  Fly   273 REDKVKELSQEIVNVEKVLKEAELMRRQIL--EVAGRDLFIIRVNLRKALKVYDLMNRLRLVGGV 335
            ||:.:..|...|.:::.|:.|.|...:|:|  .:|....::::|...||::..     |.|....
Zfish   249 REETLNGLRGRIEDIKSVMGETEQYMQQLLVRALARLPEWVVQVQKCKAVQTV-----LNLCSPS 308

  Fly   336 EVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNTTPYPIEADFQP 400
            ...:.|:||.:.|.|.:|.::..||...|.||  .|:||.       ...:|.||
Zfish   309 VTDKCLIAEAWCPVSQLPALQSALREGGRKSG--SNVDSF-------YNRLPATT---------- 354

  Fly   401 LEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTIITFPFLFAV 465
                               .|||.|..|.||.|||:::||||:|.|:|:|||.||||||||||||
Zfish   355 -------------------SPPTLFPTNSFTAGFQSIVDAYGVASYREVNPAVYTIITFPFLFAV 400

  Fly   466 MFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVFSVYMGLVYNI 530
            ||||:|||:|:.|.:..||.:..: .|.:.|.   |||..:::.|||:|||||:||:|.|.:||.
Zfish   401 MFGDVGHGLLMTLAALWMILEEND-PKLRKNT---NEIWRMMFGGRYLILLMGLFSIYTGAIYNE 461

  Fly   531 VMAKGFNLFGSSWSCR-----YNET-TVYDPAFHVTLDSSHPHFYSGHPYPLGMDPVWAVCGQDS 589
            ..:||.:.|.|.|..|     ||.| ..:....:::||.:....::| |||.|:||:|.: ..:.
Zfish   462 CFSKGLSTFSSGWHVRPNAEFYNWTEETFKKNMYLSLDPNVTGVFTG-PYPFGIDPIWGL-ANNH 524

  Fly   590 ITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFMLCLFGYLVFLIFYK 654
            :|..||.||||::::|:..|.||:.|:..|.:.....:.:.||:||::.|||||||||:|::.||
Zfish   525 LTFLNSYKMKMSVIIGVIHMTFGVCLSFFNYIHFREVSSVFLVLIPELCFMLCLFGYLIFMVIYK 589

  Fly   655 WMSYGGHKPAPYNAACAPSVLITFINMMLM---KKEDPVENCLDYMYPNERMIEFALVGIAFCTI 716
            |:.||     |.|:..|||:||.||:|.|.   |...|       :|..:..::..||.:|..::
Zfish   590 WLVYG-----PVNSDSAPSILIHFIDMFLFTENKDNKP-------LYTGQMTVQKVLVIVAVLSV 642

  Fly   717 PILLAGKPI--YLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSVD----- 774
            |:||.||||  ||..:|::.....:      ||..:||          :.|..|:|..||
Zfish   643 PVLLLGKPIQEYLSHKRKRRNPTGD------RRPLLAE----------NGSINSQQGDVDARGGG 691

  Fly   775 --NEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLTKGFANTLP 837
              .|||.:.:.:::|..|||||..||.:|:||||||||||||||.|||:|||.||:.:.|...
Zfish   692 GGEEEEFDTANVFMHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVMRQSFGQL-- 754

  Fly   838 LYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFNF 897
            .|.|..:....|..:|:|||:||::|||||||||.|||||||||:||:.|.|.....|:|
Zfish   755 SYVGSVMAALVFVGFAVLTVSILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLTPFDF 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	296/878 (34%)
tcirg1b	NP_998234.1	NtpI	27..812	CDD:224188	295/877 (34%)
tcirg1b	NP_998234.1	V_ATPase_I	28..814	CDD:279793	296/878 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582313
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850