DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-3 and atp6v0a1a

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	XP_005163855.1	Gene:	atp6v0a1a / 324307	ZFINID:	ZDB-GENE-030131-3027	Length:	840	Species:	Danio rerio

Alignment Length:	910	Identity:	312/910 - (34%)
Similarity:	495/910 - (54%)	Gaps:	111/910 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYEL---LRIVD 76
            ||||:|.|.||.|.:|:|:.|:.|:|..|.|||.::..:.......:..:|.:|.|:   ||.|:
Zfish     5 FRSEEMTLAQLFLQSESAYCCVSELGEIGMVQFRDLNPDVNAFQRKFVNEVRRCEEMDRKLRFVE 69

  Fly    77 ----SLHTYIVQLHVN-EIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNR 136
                ..:..||....| |:.:|   |:....|....|..:.||.|:....|:.:::..|..
Zfish    70 KEIKKANIPIVDTGENPEVPFP---RDMIDLEATFEKLENELKEINTNQEALKKNFLELTE---- 127

  Fly   137 MMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADKFYSFEL 201
             ::|  .|.:..::........||...||::    |......|.|..|.::.|.|..::..:||.
Zfish   128 -LKH--ILRRTQQFFDEMEDPSLLEESSTLL----DPNEVGRAAPLRLGFVAGVIGRERIPTFER 185

  Fly   202 LLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHVNIYDC 266
            :|:|:|..|:.:|.:::..|:.:...|   :.|.|...::......:..:|.|||..:..::|.|
Zfish   186 MLWRVCRGNVFLRQADIEDPLEDPATG---DNVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPC 247

  Fly   267 PSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALKVYDLMNRLRL 331
            |.:..:|::....::..|.:::.||.:.|..|:::|:.|.:.:.:..:.:||...:|..:|
Zfish   248 PETPQERKEMAAGVNTRIDDLQMVLNQTEDHRQRVLQAAAKTVRVWFIKVRKMKAIYHTLN---- 308

  Fly   332 VGGVEV-PRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNTTPYPIE 395
            :..::| .:.|:||::.|.||:..::..||..:..||                    :|.|
Zfish   309 LCNIDVTQKCLIAEIWCPVSDLDSIQFALRRGTERSG--------------------STVP---- 349

  Fly   396 ADFQPLEDMSAGAILLKKNRL-VNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTIITF 459
                        :||   ||: ....||||.:.||||.|||:::||||:::|:|:||||||||||
Zfish   350 ------------SIL---NRMQTKQTPPTYNKTNKFTSGFQSIVDAYGISNYREMNPAPYTIITF 399

  Fly   460 PFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVFSVYM 524
            ||||||||||||||:|:...:..::.:    |...|...:::|:.::::||||||||||:||:|.
Zfish   400 PFLFAVMFGDLGHGVLMTCAALYLVLR----ESRLIAQKNDSEMFSMVFAGRYIILLMGLFSMYT 460

  Fly   525 GLVYNIVMAKGFNLFGSSWSCR--YNET------TVYDPAFHVTLDSSHPHFYSGHPYPLGMDPV 581
            |::||...:|..|:|||.||.|  :.|.      .|.:.:..:.|:.:.|:.::| |||:|:||:
Zfish   461 GIIYNDCFSKSLNIFGSGWSVRPMFGEKGDNWTFAVLEKSNVLQLNPAVPNVFTG-PYPVGIDPI 524

  Fly   582 WAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFMLCLFGY 646
            |.: ..:.:|..||.||||:|:||:..|:||:.|:..|.:...:..::.|..||::|||:.||||
Zfish   525 WNI-ATNKLTFLNSFKMKMSIILGVIHMIFGVSLSLFNHLYFRKPLNIYLGFIPEIIFMVSLFGY 588

  Fly   647 LVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIEFALVGI 711
            ||.||||||::|...     ::..|||:|||||||.|....||...   ..|..:.:|:..||.|
Zfish   589 LVLLIFYKWIAYDAK-----SSRVAPSLLITFINMCLFSYNDPTNK---PFYTGQVVIQCLLVII 645

  Fly   712 AFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSR-QKSVDN 775
            |...:|.:|..|.: :|||:...:       :.:..|....:......|:|:...... |.|.:.
Zfish   646 ALSCVPCMLIVKTL-VMRRQHLWR-------RHLGTQNFGGIHVGNGPTEDEAEIIQHDQLSQNT 702

  Fly   776 EEEHEMS--EIW------IHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLTKGF 832
            |||.|.|  |::      :|..|||||..||.:|:||||||||||||||.|||:|||.||:..|.
Zfish   703 EEEPEPSEEEVFNFADEAVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWSMVMHMGL 767

  Fly   833 ANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFNF 897
            ::.  .:.|...|...|..:|:|||.||::|||||||||.|:|||||||:||:.|.|..|..|.|
Zfish   768 SSR--SFGGFIFLSIIFCFFAVLTVFILLVMEGLSAFLHALKLHWVEFQNKFYTGQGFKFMPFTF 830

Fly 898 897
Zfish 831 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	299/885 (34%)
atp6v0a1a	XP_005163855.1	NtpI	27..830	CDD:224188	299/886 (34%)
atp6v0a1a	XP_005163855.1	V_ATPase_I	28..830	CDD:279793	299/885 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.780