DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-3 and Atp6v0a4

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	XP_006236358.1	Gene:	Atp6v0a4 / 296981	RGDID:	1305055	Length:	829	Species:	Rattus norvegicus

Alignment Length:	921	Identity:	321/921 - (34%)
Similarity:	489/921 - (53%)	Gaps:	140/921 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIV-- 75
            |.||||:|.|.|:.|..|.|:.|:.|:|..|.|||.::..........:..:|.:|..|.||:
  Rat     3 SVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLERILRF 67

  Fly    76 --DSLHTYIVQLHVNEIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRMM 138
              |.:...|:      |..||.|....| .:::.....:|:::..|.....:.:..|......:.
  Rat    68 LEDEMQNEII------IQVPDKDPGTPL-PREMITLETTLEKLEGELQEANQSHQALKKSFLELT 125

  Fly   139 EHSFALNKANKYMVSDMGSELLYSESTVIG---LVQDATTTSG-----AYPA----HLNYMIGCI 191
            |..:.|.|...:          :...|.:|   .|:|   |||     |.||    .|.:..|.|
  Rat   126 ELKYLLKKTQDF----------FETETNLGEDFFVED---TSGLLELRAMPAFMTGKLGFTAGVI 177

  Fly   192 RADKFYSFELLLYRLCSFNLIIRFSEMPS----PVYEYHYGYKPERVRKFAILMMASSTMIWPKV 252
            ..::..|||.||:|:|..|:.::||||.:    ||.:       |.::|...::......:..|:
  Rat   178 NRERMASFERLLWRVCRGNVYLKFSEMDTLLEDPVTK-------EEIKKNIFIIFYQGEQLRLKI 235

  Fly   253 LKICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRD--LFIIRVN 315
            .|||..:...||.||..|::|.:.:..::..:.::..|:.:.|..|:::|:.|..:  .::|:|.
  Rat   236 KKICDGFRATIYPCPEHAAERREMLASVNVRLEDLITVITQTESHRQRLLQEAASNWHSWVIKVQ 300

  Fly   316 LRKALKVYDLMNRLRLVGGVEVPRY-LLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDE 379
            ..||  ||.::|    :..::|.:. ::||::.|.:|...::..|.....:||
  Rat   301 KMKA--VYHVLN----MCNIDVTQQCIIAEIWFPVADTRHIKKALEQGMELSG------------ 347

  Fly   380 MNDMKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMA 444
                     ::..||..:.:...|                 |||:.|.||||.||||::||||:.
  Rat   348 ---------SSMVPIMTEVETKTD-----------------PPTFNRTNKFTAGFQNIVDAYGVG 386

  Fly   445 DYKELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYA 509
            .|:|:||||||||||||||||||||.|||:::::.:..|:..    |::.:...|.||:.||.:.
  Rat   387 SYREINPAPYTIITFPFLFAVMFGDCGHGMVMLMAALWMVLN----ERHLLAQKSTNEMWNIFFN 447

  Fly   510 GRYIILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCR-------YNETTV-YDPAFHVTLDSSHP 566
            |||:|||||:||:|.||:||...:|.||:||||||.:       :|...| .:|  ::.||.:.|
  Rat   448 GRYLILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWNAHVVEQNP--YLQLDPAIP 510

  Fly   567 HFYSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLIL 631
            ..|||:|||.|:||:|.: ..:.:|..||.||||:::|||..|:||:.|:..|.:...|..::||
  Rat   511 GVYSGNPYPFGIDPIWNL-ASNKLTFLNSYKMKMSVILGIVHMIFGVILSLFNHIYFRRTLNIIL 574

  Fly   632 VVIPQMIFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDY 696
            ..||:|||||.|||||||:|.:||..|..|     .:..|||:||.||.|.|...:|.....|
  Rat   575 QFIPEMIFMLSLFGYLVFMIIFKWCQYDAH-----TSQKAPSILIHFIGMFLFDYDDSSNAPL-- 632

  Fly   697 MYPNERMIEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTD 761
             |.:::.::...|.||..::|.:|..||..|..:.:|.|         ::..||.|  ..|....
  Rat   633 -YGHQQEVQTFFVIIALVSVPWMLLIKPFILRAKHQKSQ---------LQSFTIHE--DAMEGPS 685

  Fly   762 DDNSETSRQKSVDNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHM 826
            ...:..:......:|||....:|::|..|||||..||.:|:||||||||||||||.:||:|||.|
  Rat   686 VKKTAGAHGTKEGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAELSEVLWTM 750

  Fly   827 VLT-----KGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFG 886
            |::     :|:...:    ||.::.|.|   |:||||||::|||||||||.|||||||||:||:.
  Rat   751 VMSIGLRLRGWGGLV----GVFIIFAVF---AVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYE 808

  Fly   887 GAGESFKAFNF 897
            |||..|..|:|
  Rat   809 GAGFKFSPFSF 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	308/894 (34%)
Atp6v0a4	XP_006236358.1	NtpI	28..820	CDD:224188	309/896 (34%)
Atp6v0a4	XP_006236358.1	V_ATPase_I	28..819	CDD:279793	308/894 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820