Protein Alignment Vha100-3 and Tcirg1

DIOPT Version :10

• Sequence 1: NP_725837.1
• Gene: Vha100-3 / 246543
• FlyBaseID: FBgn0028669
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_954520.3
• Gene: Tcirg1 / 293650
• RGDID: 735136
• Length: 834
• Species: Rattus norvegicus
• Alignment Length: 917
• Identity: 313/917 - (34%)
• Similarity: 478/917 - (52%)
• Gaps: 122/917 - (13%)

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||::.|.||||.|.:|::|:.::|..|.|:|.::.:........:..:|.:|.||    :.
  Rat     3 SMFRSEEVALVQLLLPTASAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVEVRRCEEL----EK 63

  Fly    78 LHTYIVQLHVNEIFYPDVDR--------ENRL---KEKDLAKYSDSLKRIHVEASAVTEHYYRLD 131
            ..|::.:         :|.|        |..|   ..:||.:..:...|:..|...|..:...|.
  Rat    64 TFTFLRE---------EVQRAGLTLTPPEGTLPAPPPRDLLRIQEETDRLAQELRDVRGNQQALR 119

  Fly   132 SRRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAY-PAHLNYMIGCIRADK 195
            ::.:::..||..|.:::...::.:.:|...:|.|.:     .:.|.|.: ...:|::.|.:...|
  Rat   120 AQLHQLQLHSAVLGQSHAPPMAAVHTEGPTTERTPL-----LSATPGPHADLKVNFVAGAVEPCK 179

  Fly   196 FYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKI--CAH 258
            ..:.|.||:|.|...||..|.|....:.:...| :|.....|.|.....  .|..||.||  |.|
  Rat   180 AAALERLLWRACRGFLIASFKETEGQLEDPVTG-EPATWMTFVISYWGE--QIGQKVRKITDCFH 241

  Fly   259 YHVNIYDCPSSASQREDKVK---ELSQEIVNVEKVLKEAELMRRQILEVAGRDLFII---RVNLR 317
            .||..|     ..|.|.:::   :|.|:...:::||.|.|   |.:.:|.||...::   :|.:|
  Rat   242 CHVFPY-----LEQEEARLRTLQQLQQQSQELQEVLGETE---RFLSQVLGRVQQLLPPGQVQIR 298

  Fly   318 KALKVYDLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASR---ISGGADNIDSSDEDE 379
            |...||..:|:..:   ....:.|:|||:..:.|:|.|:..|::.|.   :|..|..|
  Rat   299 KMKAVYLTLNQCSV---NTTHKCLIAEVWCATRDLPTVQQALQSGSSEEGVSAVAHRI------- 353

  Fly   380 MNDMKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMA 444
                                |.:|                ||||..|.|:||..||.::||||:.
  Rat   354 --------------------PCQD----------------MPPTLIRTNRFTSSFQGIVDAYGVG 382

  Fly   445 DYKELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYA 509
            .|:|:||||||||||||||||||||:|||:|:.||:..|:.    .|......|::|||....:.
  Rat   383 RYREVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVL----TENQPAVKTTQNEIWQTFFG 443

  Fly   510 GRYIILLMGVFSVYMGLVYNIVMAKGFNLFGSSWS--CRYNETTVYDPAFH----VTLDSSHPHF 568
            |||::||||:||:|.|.:||...::...:|.|.||  ...|::...|....    :||:.:....
  Rat   444 GRYLLLLMGLFSIYTGFIYNECFSRATTIFPSGWSVAAMANQSGWSDEYLSQHPMLTLNPNITGV 508

  Fly   569 YSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVV 633
            :.| |||.|:||:|:: ..:.::..||.||||:::||::.|.||:.|:..|.|...:...|:|..
  Rat   509 FLG-PYPFGIDPIWSL-ATNHLSFLNSFKMKMSVILGVTHMAFGVFLSIFNHVHFGQAHRLLLET 571

  Fly   634 IPQMIFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMY 698
            :|::||:|.|||||||||.|||:..     :..:|:.|||:||.||||.|. .::|....|   :
  Rat   572 VPELIFLLGLFGYLVFLIVYKWLYV-----SAASASSAPSILIHFINMFLF-SQNPTNRLL---F 627

  Fly   699 PNERMIEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDD 763
            ..:.::::|||.:|..|:||||.|.|:||:|:..:...:|.....|....:...:.|....|.::
  Rat   628 HGQVVVQYALVVLALATVPILLLGTPLYLLRQHHRRNTQRRPTAGRQDEDSDKLLASPDASTLEN 692

  Fly   764 NSETSRQK---SVDNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWH 825
            :.....:|   |.|.|.|...|||::|..|||||..||.:|:||||||||||||||.|||:|||.
  Rat   693 SWSPDEEKAGSSGDEEAEFVPSEIFMHQAIHTIEFCLGCISNTASYLRLWALSLAHAQLSEVLWA 757

  Fly   826 MVLTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGE 890
            ||:..|......:.....||:..|.|:|:||||||::|||||||||.|||||||||:||:.|.|.
  Rat   758 MVMRIGLGMGREIGVASVVLVPVFAAFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGTGY 822

  Fly   891 SFKAFNF 897
            ....|.|
  Rat   823 KLSPFAF 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:460232	299/890 (34%)
Tcirg1	NP_954520.3	V_ATPase_I	27..829	CDD:460232	299/891 (34%)