Protein Alignment Vha100-3 and Tcirg1

DIOPT Version :10

• Sequence 1: NP_725837.1
• Gene: Vha100-3 / 246543
• FlyBaseID: FBgn0028669
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_058617.3
• Gene: Tcirg1 / 27060
• MGIID: 1350931
• Length: 834
• Species: Mus musculus
• Alignment Length: 913
• Identity: 306/913 - (33%)
• Similarity: 480/913 - (52%)
• Gaps: 114/913 - (12%)

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||::.|.||||.|.:|::|:.::|..|.|:|.::.:........:...|.:|.||    :.
Mouse     3 SMFRSEEVALVQLLLPTGSAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVDVRRCEEL----EK 63

  Fly    78 LHTYIVQLHVNEIFYPDVDR--------ENRL---KEKDLAKYSDSLKRIHVEASAVTEHYYRLD 131
            ..|::.:         :|.|        |..|   ..:||.:..:...|:..|...|..:...|.
Mouse    64 TFTFLRE---------EVQRAGLTLAPPEGTLPAPPPRDLLRIQEETDRLAQELRDVRGNQQALR 119

  Fly   132 SRRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAY-PAHLNYMIGCIRADK 195
            ::.:::..||..|.:::...|:...:|..:||:|.:     ...|.|.: ...:|::.|.:...|
Mouse   120 AQLHQLRLHSAVLGQSHSPPVAADHTEGPFSETTPL-----LPGTRGPHSDLKVNFVAGAVEPYK 179

  Fly   196 FYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYH 260
            ..:.|.||:|.|...||..|.|....:.:...| :|.....|.|.....  .|..|:.||...:|
Mouse   180 AAALERLLWRACRGFLIASFRETEGQLEDPVTG-EPATWMTFVISYWGE--QIGQKIRKITDCFH 241

  Fly   261 VNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFII---RVNLRKALKV 322
            .:::........|...:::|.|:...:::||.|.:   |.:.:|.||...::   :|.:.|...|
Mouse   242 CHVFPYLEQEEARFRTLQQLQQQSQELQEVLGETD---RFLSQVLGRVQQLLPPWQVQIHKMKAV 303

  Fly   323 YDLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASR---ISGGADNIDSSDEDEMNDMK 384
            |..:|:..:   ....:.|:|||:..:.|:|.|:..|::.|.   :|..|..|
Mouse   304 YLTLNQCSV---NTTHKCLIAEVWCAARDLPTVQQALQSGSSEEGVSAVAHRI------------ 353

  Fly   385 TMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKEL 449
                           |.:|                ||||..|.|:||..||.::||||:..|:|:
Mouse   354 ---------------PCQD----------------MPPTLIRTNRFTSSFQGIVDAYGVGRYREV 387

  Fly   450 NPAPYTIITFPFLFAVMFGDLGHGILLILFS-SLMIWKHREIEKYQINATSENEILNILYAGRYI 513
            ||||||||||||||||||||:|||:|:.||: ::::.::|...|     .::|||....:.|||:
Mouse   388 NPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVLTENRPAVK-----AAQNEIWQTFFGGRYL 447

  Fly   514 ILLMGVFSVYMGLVYNIVMAKGFNLFGSSWS--CRYNETTVYDPAFH----VTLDSSHPHFYSGH 572
            :||||:||||.|.:||...::...:|.|.||  ...|::...|....    :||:.:....:.|
Mouse   448 LLLMGLFSVYTGFIYNECFSRATTIFPSGWSVAAMANQSGWSDEYLSQHSMLTLNPNITGVFLG- 511

  Fly   573 PYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQM 637
            |||.|:||:|:: ..:.::..||.||||:::||::.|.||:.|:..|.|...:...|:|..:|::
Mouse   512 PYPFGIDPIWSL-ATNHLSFLNSFKMKMSVILGVTHMAFGVFLSIFNHVHFGQAHRLLLETLPEL 575

  Fly   638 IFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNER 702
            ||:|.|||||||||.|||::.     :..:|:.|||:||.||||.|. .::|..:.|   :..:.
Mouse   576 IFLLGLFGYLVFLIVYKWVNV-----SAASASSAPSILIHFINMFLF-SQNPTNHLL---FHGQE 631

  Fly   703 MIEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSET 767
            ::::.||.:|..|:||||.|.|:||:|:.|..:..:.|...:....|...:.|....|.:::...
Mouse   632 VVQYVLVVLALATVPILLLGTPLYLLRQHRHRRNTQRRPAGQQDEDTDKLLASPDASTLENSWSP 696

  Fly   768 SRQKS---VDNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLT 829
            ..:|:   .|.|.|...|||::|..|||||..||.:|:||||||||||||||.|||:|||.||:.
Mouse   697 DEEKAGSPGDEETEFVPSEIFMHQAIHTIEFCLGCISNTASYLRLWALSLAHAQLSEVLWAMVMR 761

  Fly   830 KGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKA 894
            .|......:.....||:..|.|:|:||||||::|||||||||.|||||||||:||:.|.|.....
Mouse   762 IGLGMGREIGVAAVVLVPVFAAFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSP 826

  Fly   895 FNF 897
            |.|
Mouse   827 FTF 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:460232	292/886 (33%)
Tcirg1	NP_058617.3	V_ATPase_I	27..829	CDD:460232	292/887 (33%)