Protein Alignment Vha100-3 and vph1

DIOPT Version :10

• Sequence 1: NP_725837.1
• Gene: Vha100-3 / 246543
• FlyBaseID: FBgn0028669
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_594219.2
• Gene: vph1 / 2542310
• PomBaseID: SPAC16E8.07C
• Length: 831
• Species: Schizosaccharomyces pombe
• Alignment Length: 923
• Identity: 279/923 - (30%)
• Similarity: 438/923 - (47%)
• Gaps: 138/923 - (14%)

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||::.|.||.|.||:|...:..:|....:.|.::..:.......:.:::.:..:..|::..
pombe     4 SLFRSEEVSLVQLYLPTESARPIMSALGELSTIHFKDLNPDVVAFQRSFVREIRRLTDTERLLRY 68

  Fly    78 LHTYIVQLHVNEIFYPD----VDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRMM 138
            ||:   ::.:|.|..||    ...|:.|:...:....:.:.|:......:.|....|::|..:.:
pombe    69 LHS---EIDLNGIHVPDHNLPPSYESVLESSTIEDIIERITRLEARVRQLVESSQLLEARYLQQL 130

  Fly   139 EHSFALNKA---------------NKYMVSDMGSELLYSESTVIGLVQDATT--TSGAYPAH--- 183
            |.:..|.||               |.|..|.:.|.   .:.|...|:::|..  |:|.:.:.
pombe   131 EFANVLTKADAFFSKSGNTVDPLRNNYETSSIFSG---EDDTTAPLIENALELGTTGTFDSEETS 192

  Fly   184 ------LNYMIGCIRADKFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMM 242
                  |:::.|.|...||...|.:|:|....||.|.  ::.:.....|...|.|  .|...|::
pombe   193 PQMNTTLDFVSGIIPTVKFQFLERILWRTLRGNLFIH--QVRADDSLIHGAEKNE--EKTIFLVI 253

  Fly   243 ASSTMIWPKVLKICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGR 307
            |..|.|..::.||.......::.....|..|..::::.:..|.::..||:.........|.....
pombe   254 AHGTQILLRIRKISESLGATLFPVEEDAPGRTSQIQQANVSISDLNAVLENTRSALYTELTFIAE 318

  Fly   308 DLFIIRVNLRKALKVYDLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNI 372
            .:......|.|...|:.:||   |....:..:.|:||.:.|::::|.|:..|||.|      |..
pombe   319 HISAWEAVLHKDKTVFQVMN---LFNYDQNHKCLIAEGWCPTANLPMVQKTLRNIS------DLT 374

  Fly   373 DSSDEDEMNDMKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNL 437
            ||.....:|.:.|                                :..||||||:||||.|||::
pombe   375 DSQAPTILNVVHT--------------------------------SEQPPTYFRVNKFTEGFQSI 407

  Fly   438 IDAYGMADYKELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSE-N 501
            ||:||:|.|:|:|.....|:|||||||:||||||||.::...:.:.:     :.:..:.|..: :
pombe   408 IDSYGIATYREVNHGIVAIVTFPFLFAIMFGDLGHGAIMASVALMFV-----LYEKTLGAKKDLD 467

  Fly   502 EILNILYAGRYIILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCRYNETTVYDPAFHVTLDSSHP 566
            ||:.:::.||||:||||:||:|:|.|||.:.:|..::|.|.|            .:.|..:.:..
pombe   468 EIVGMVFYGRYIVLLMGLFSMYVGFVYNDLFSKPMSIFSSRW------------VWPVKSEEAIA 520

  Fly   567 HFYSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLIL 631
            .......||:|:||.|. ...:::...||.|||::|:||:..|.|.|.|:.:|.....||.|:..
pombe   521 RAVQVGTYPIGIDPTWH-SADNNLLFMNSYKMKLSIILGVIHMTFCLFLSLSNYRFFKRKLDIYA 584

  Fly   632 VVIPQMIFMLCLFGYLVFLIFYKW-MSYGGHKPAPYNAACAPSVLITFINMMLMKKEDP--VENC 693
            |.:|.:||:..:|||||..|.||| :.:......|      ||:|    ||:::....|  :|
pombe   585 VFVPSLIFLEAIFGYLVITIVYKWCIDWKAKDLQP------PSLL----NMLILMFLSPGTLE-- 637

  Fly   694 LDYMYPNERMIEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMR 758
             |.:||.::.::..||..|...:|.||..||..|.||....:.:.:            .:.|.:.
pombe   638 -DQLYPGQKYLQVGLVIAALICVPWLLIVKPFVLWRRHSNEENKYQ------------SLNSDLP 689

  Fly   759 YTDDDNSETSRQKSVDNEEEH----EMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQL 819
            ..|    |.....:||::|:.    |:.|:.||..|||||..||.|||||||||||||||||:||
pombe   690 NVD----EADALMAVDSQEKQAEPFELGEVVIHQVIHTIEFCLGCVSHTASYLRLWALSLAHNQL 750

  Fly   820 SDVLWHMVLTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKF 884
            |.|||:|.|..||..|  ...|...::..|..|.|.|..:||.|||.||.||:|||||||..||.
pombe   751 SSVLWNMTLANGFRMT--GIVGSIFVVILFGFWFIATCVVLVAMEGTSAMLHSLRLHWVEGMSKH 813

  Fly   885 FGGAGESFKAFNF 897
            |.|.|.:|..|.|
pombe   814 FEGEGYAFTPFTF 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:460232	266/896 (30%)
vph1	NP_594219.2	V_ATPase_I	28..826	CDD:460232	266/897 (30%)