DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and ATP6V0A2

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_036595.2	Gene:	ATP6V0A2 / 23545	HGNCID:	18481	Length:	856	Species:	Homo sapiens

Alignment Length:	938	Identity:	318/938 - (33%)
Similarity:	474/938 - (50%)	Gaps:	151/938 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||.|.|.||.|.:..|::||..:|..|.|||.::..........:..:|.:|.||.||:
Human     3 SLFRSETMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERIL-- 65

  Fly    78 LHTYIVQLHVNEIFYPDVDRENRLKE----------KDLAKYSDSLKRIHVEASAVTEHYYRLDS 132
              .|:||    ||...|:.    |.|          |.:.:..:.|:::.||...||::..:|..
Human    66 --VYLVQ----EINRADIP----LPEGEASPPAPPLKQVLEMQEQLQKLEVELREVTKNKEKLRK 120

  Fly   133 RRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYP---AHLNYMIGCIRAD 194
            ....::|::..|.....::..::..|..|.|..  .|..|:........   |.|.::.|.|...
Human   121 NLLELIEYTHMLRVTKTFVKRNVEFEPTYEEFP--SLESDSLLDYSCMQRLGAKLGFVSGLINQG 183

  Fly   195 KFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHY 259
            |..:||.:|:|:|....|:.::|:...:.:...|   |.::.:..|:......|..||.|||..|
Human   184 KVEAFEKMLWRVCKGYTIVSYAELDESLEDPETG---EVIKWYVFLISFWGEQIGHKVKKICDCY 245

  Fly   260 HVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALKVYD 324
            |.::|..|::|.:|.:..:.|:..|.::..||.:.|...||:|..|...::...:.::|...:|.
Human   246 HCHVYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVYSRVIQVKKMKAIYH 310

  Fly   325 LMNRLRLVGGVEVP-RYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMP- 387
            ::|    :...:|. :.|:|||:.|.:|:.::...|...||.||.                |:|
Human   311 MLN----MCSFDVTNKCLIAEVWCPEADLQDLRRALEEGSRESGA----------------TIPS 355

  Fly   388 --NTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELN 450
              |..|                         ....|||..|.||||.||||::||||:..|:|:|
Human   356 FMNIIP-------------------------TKETPPTRIRTNKFTEGFQNIVDAYGVGSYREVN 395

  Fly   451 PAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIW--KHREIEKYQINATSENEILNILYAGRYI 513
            ||.:|||||||||||||||.|||.::.||:.|::.  .|..:.:.|       ||:.:.:.||||
Human   396 PALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPRLNQSQ-------EIMRMFFNGRYI 453

  Fly   514 ILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCRYNETTVYDPAFH----------------VTLD 562
            :||||:||||.||:||...:|..|||||.|:.....::.:.||.|                :.||
Human   454 LLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHPPAEHKKMVLWNDSVVRHNSILQLD 518

  Fly   563 SSHPHFYSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKA 627
            .|.|..:.| |||||:||:|.: ..:.:|..||.||||:::|||..|.||:.|...|.:...:|.
Human   519 PSIPGVFRG-PYPLGIDPIWNL-ATNRLTFLNSFKMKMSVILGIIHMTFGVILGIFNHLHFRKKF 581

  Fly   628 DLILVVIPQMIFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVEN 692
            ::.||.||:::||||:||||:|:|||||:.:...     .:..|||:||.||||.|.    |...
Human   582 NIYLVSIPELLFMLCIFGYLIFMIFYKWLVFSAE-----TSRVAPSILIEFINMFLF----PASK 637

  Fly   693 CLDYMYPNERMIEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTM 757
             ...:|..:..::..|:.:...::|:|..|||::|:             :....|......||
Human   638 -TSGLYTGQEYVQRVLLVVTALSVPVLFLGKPLFLL-------------WLHNGRSCFGVNRS-- 686

  Fly   758 RYT---DDDNSETSRQKSVDNE---------------EEHEMSEIWIHSGIHTIETVLGSVSHTA 804
            .||   .|...|.|...|.|.|               ||....||.:...||:||..||.:|:||
Human   687 GYTLIRKDSEEEVSLLGSQDIEEGNHQVEDGCREMACEEFNFGEILMTQVIHSIEYCLGCISNTA 751

  Fly   805 SYLRLWALSLAHDQLSDVLWHMVLTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAF 869
            ||||||||||||.|||||||.|::..|.  .:...|||.:|:.....:|:||:.||::|||||||
Human   752 SYLRLWALSLAHAQLSDVLWAMLMRVGL--RVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAF 814

  Fly   870 LHTLRLHWVEFQSKFFGGAGESFKAFNF 897
            ||.:||||||||:||:.|||..|..|:|
Human   815 LHAIRLHWVEFQNKFYVGAGTKFVPFSF 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	304/911 (33%)
ATP6V0A2	NP_036595.2	V_ATPase_I	27..842	CDD:307581	304/912 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148437
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750