Protein Alignment Vha100-3 and Atp6v0a2

DIOPT Version :10

• Sequence 1: NP_725837.1
• Gene: Vha100-3 / 246543
• FlyBaseID: FBgn0028669
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: NP_035726.2
• Gene: Atp6v0a2 / 21871
• MGIID: 104855
• Length: 856
• Species: Mus musculus
• Alignment Length: 937
• Identity: 321/937 - (34%)
• Similarity: 478/937 - (51%)
• Gaps: 149/937 - (15%)

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||.|.|.||.|.:..|::||..:|..|.|||.::..........:..:|.:|.||.||:
Mouse     3 SLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERIL-- 65

  Fly    78 LHTYIVQLHVNEIFYPDVDRENRLKE----------KDLAKYSDSLKRIHVEASAVTEHYYRLDS 132
              .|:||    ||...|:.    |.|          |.:.:..:.|:::.||...||::..:|..
Mouse    66 --VYLVQ----EITRADIP----LPEGEASPPAPPLKHVLEMQEQLQKLEVELREVTKNKEKLRK 120

  Fly   133 RRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYP---AHLNYMIGCIRAD 194
            ....::|::..|.....::..::..|..|.|..  .|..|:........   |.|.::.|.|:..
Mouse   121 NLLELVEYTHMLRVTKTFLKRNVEFEPTYEEFP--ALENDSLLDYSCMQRLGAKLGFVSGLIQQG 183

  Fly   195 KFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHY 259
            :..:||.:|:|.|....|:.::|:...:.:...|   |.::.:..|:......|..||.|||..|
Mouse   184 RVEAFERMLWRACKGYTIVTYAELDECLEDPETG---EVIKWYVFLISFWGEQIGHKVKKICDCY 245

  Fly   260 HVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALKVYD 324
            |.:||..|::|.:|.:..:.|:..|.::..||.:.|...||:|..|...:....|.:||...:|.
Mouse   246 HCHIYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVCSRVVQVRKMKAIYH 310

  Fly   325 LMNRLRLVGGVEVP-RYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMP- 387
            ::|    :...:|. :.|:|||:.|..|:|.:...|...||.||.                |:|
Mouse   311 MLN----MCSFDVTNKCLIAEVWCPEVDLPGLRRALEEGSRESGA----------------TIPS 355

  Fly   388 --NTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELN 450
              ||.|                         ....|||..|.||||.||||::||||:..|:|:|
Mouse   356 FMNTIP-------------------------TKETPPTLIRTNKFTEGFQNIVDAYGVGSYREVN 395

  Fly   451 PAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIW--KHREIEKYQINATSENEILNILYAGRYI 513
            ||.:|||||||||||||||.|||.::.||:.|::.  .|..:.:.|       |||.:.:.||||
Mouse   396 PALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPRLSQSQ-------EILRMFFDGRYI 453

  Fly   514 ILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCR-----------------YNETTVYDPAFH--- 558
            :||||:||||.||:||...:|..|||||.|:..                 :|::|:.    |
Mouse   454 LLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHSPEEQRKMVLWNDSTIR----HSRT 514

  Fly   559 VTLDSSHPHFYSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLM 623
            :.||.:.|..:.| |||.|:||:|.: ..:.:|..||.||||:::|||..|.||:.|...|.:..
Mouse   515 LQLDPNIPGVFRG-PYPFGIDPIWNL-ATNRLTFLNSFKMKMSVILGIFHMTFGVVLGIFNHLHF 577

  Fly   624 NRKADLILVVIPQMIFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKED 688
            .:|.::.||.:|:::||||:||||:|:|.|||::|...     .:..|||:||.||||.|.
Mouse   578 RKKFNVYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAE-----TSREAPSILIEFINMFLF---- 633

  Fly   689 PVENCLDYMYPNERMIEFALVGIAFCTIPILLAGKPIYL-----------MRRR--RKMQQERER 740
            |... ...:||.:..::..||.:....:|:|..|||::|           |.|.  ..::::.|.
Mouse   634 PTSK-THGLYPGQAHVQRVLVALTVLAVPVLFLGKPLFLLWLHNGRNCFGMSRSGYTLVRKDSEE 697

  Fly   741 DFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSVDNEEEHEMSEIWIHSGIHTIETVLGSVSHTAS 805
            :...:..|.|.|..|.|       .|..|:.:.   ||....||.:...||:||..||.:|:|||
Mouse   698 EVSLLGNQDIEEGNSRM-------EEGCREVTC---EEFNFGEILMTQAIHSIEYCLGCISNTAS 752

  Fly   806 YLRLWALSLAHDQLSDVLWHMVLTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFL 870
            |||||||||||.|||||||.|::..|.  .:...|||.:|:.....:|:||:.||::||||||||
Mouse   753 YLRLWALSLAHAQLSDVLWAMLMRVGL--RVDTTYGVLLLLPVMAFFAVLTIFILLVMEGLSAFL 815

  Fly   871 HTLRLHWVEFQSKFFGGAGESFKAFNF 897
            |.:||||||||:||:.|||..|..|:|
Mouse   816 HAIRLHWVEFQNKFYVGAGTKFVPFSF 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:460232	307/910 (34%)
Atp6v0a2	NP_035726.2	V_ATPase_I	27..839	CDD:460232	306/908 (34%)