DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and vha-5

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_501399.1	Gene:	vha-5 / 177626	WormBaseID:	WBGene00006914	Length:	873	Species:	Caenorhabditis elegans

Alignment Length:	955	Identity:	312/955 - (32%)
Similarity:	479/955 - (50%)	Gaps:	150/955 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |..|||:|..|||::..:.||:.:.|:|....|||.::..........:.|.:.:..|:.|.:..
Worm     3 SLSRSEEMRFCQLIVEKDAAFNIVAEIGKQPYVQFKDLNPNVNSFQRTFVKDIRRYDEMERKLRF 67

  Fly    78 LHTYIVQLHVNEIFYP---DVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRMME 139
            |.:.||:   :||..|   |......|...:|.....:|..:..:..::.:...:|.:....:.|
Worm    68 LESQIVK---DEIVIPGRVDTGDYTILPTSELNTLEGTLTELEKDVKSMNDSDSQLKANFMDLKE 129

  Fly   140 HSFALNKANKYM---VSDMGSELLYSESTVIGLVQDATTTSGAYP----AHLNYMIGCIRADKFY 197
            ....|:|.:::.   |.|...|.|           :.....||.|    ..:||::|.||.::..
Worm   130 WDAVLDKTDEFFQGGVDDQAQEEL-----------ENLDEEGAVPRVEKGPVNYLVGIIRRERLN 183

  Fly   198 SFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHVN 262
            .||.:|:|.|.....||.|::...:.:...|   |:|.|...::......:...|.|:|..:...
Worm   184 GFERVLWRACHHTAYIRSSDIEEELEDPGTG---EKVHKSVFIIFLKGDRMRSIVEKVCDGFKAK 245

  Fly   263 IY-DCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALKVYDLM 326
            :: :||.:..:|:....::...|.:::.||.:....|.::|:.|..:.......:|....|:.::
Worm   246 LFKNCPKTFKERQSARNDVRARIQDLQTVLGQTREHRFRVLQAAANNHHQWLKQVRMIKTVFHML 310

  Fly   327 NRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNTTP 391
            |.....|   :.|:.:.|.:||...|.:|    |.|  |..||:...||.:..:|.::|
Worm   311 NLFTFDG---IGRFFVGECWIPLKHVEDV----RKA--IEVGAERSGSSVKPVLNILET------ 360

  Fly   392 YPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTI 456
                                      :..||||...||||..||.::|:||:|.|:|||||||||
Worm   361 --------------------------SVTPPTYNETNKFTAVFQGIVDSYGIATYRELNPAPYTI 399

  Fly   457 ITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVFS 521
            |||||||:.||||||||.::::.....:.:.:.::...|    ::||.|:.:.|||||||||:||
Worm   400 ITFPFLFSCMFGDLGHGCIMLMAGLWFVLREKNLQARNI----KDEIFNMFFGGRYIILLMGLFS 460

  Fly   522 VYMGLVYNIVMAKGFNLFGSSWSCRYNET--------TVYDPAFHVTLDSSHPHFYSGHPYPLGM 578
            ::.|::||.:.||.||:|||.|...||.:        |.:.....|.|.....:.::|.||..|:
Worm   461 IHAGIIYNDMFAKSFNIFGSGWKNPYNASEIEGWINRTEHGKEMLVELAPEDAYDHAGGPYSFGV 525

  Fly   579 DPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFMLCL 643
            ||:|.: .::.:...||:|||::::||||||.||:.|:..|......|.|:..|.||||:||.|:
Worm   526 DPIWNI-AENKLNFLNSMKMKLSVILGISQMTFGVILSFFNHTYNKSKIDIFTVFIPQMLFMGCI 589

  Fly   644 FGYLVFLIFYKWMSY-------------GGHKPAPYNAACAPSVLITFINMMLMKKED------- 688
            |.||...|..||:.:             |.|        ||||:||..|||.:||..:
Worm   590 FMYLCLQIILKWLFFWTKEATVFGQIYPGSH--------CAPSLLIGLINMFMMKDRNAGFVVDG 646

  Fly   689 --------PVENC-LDYMYPNERMIEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKR 744
                    .||.| |...||.:.:||..||.||...:|::|.||||:.:.:::|..:|...:
Worm   647 GKVNGEYREVETCYLSQWYPGQSVIEMILVVIAVICVPVMLFGKPIHHVMQQKKKAKELHGN--- 708

  Fly   745 MRRQTIAEMRSTMRYTDDDNSET-----SRQKSVDNEEE----HE---MSEIWIHSGIHTIETVL 797
                  |.:|:.:   ..|:||.     |:::...:||.    ||   ..:|.:|..|||||.||
Worm   709 ------ATVRANV---VSDSSEIVLNGGSKKEGAAHEEHGHGGHEDESFGDIMVHQAIHTIEYVL 764

  Fly   798 GSVSHTASYLRLWALSLAHDQLSDVLWHMVLTK---GFANTLPLYYGVPVLMATFFAWAILTVAI 859
            |.|||||||||||||||||.|||:||||||...   |.:.|.    |...:...||.:.:||::|
Worm   765 GCVSHTASYLRLWALSLAHAQLSEVLWHMVFVTGGLGISGTA----GFIAVYVVFFIFFVLTISI 825

  Fly   860 LVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFNFPTSNQRS 904
            ||:||||||||||||||||||||||:.|.|..|..::|.|:.|.:
Worm   826 LVLMEGLSAFLHTLRLHWVEFQSKFYLGLGYPFVPYSFKTALQEA 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	299/921 (32%)
vha-5	NP_501399.1	V_ATPase_I	28..863	CDD:279793	299/921 (32%)
vha-5	NP_501399.1	NtpI	35..864	CDD:224188	297/915 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.770