DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and unc-32

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001023017.1	Gene:	unc-32 / 176257	WormBaseID:	WBGene00006768	Length:	905	Species:	Caenorhabditis elegans

Alignment Length:	953	Identity:	319/953 - (33%)
Similarity:	476/953 - (49%)	Gaps:	148/953 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDSLH 79
            :|||.|.|.||.|.::.::.|:.|:|..|.|||.::..:.......|..:|.:|.|:.|.:..|.
Worm    17 YRSEQMCLAQLYLQSDASYQCVAELGELGLVQFRDLNPDVSSFQRKYVNEVRRCDEMERKLRYLE 81

  Fly    80 -----TYIVQLHVNEIFYPD-------VD-------RENRLKEKDLAKYSDSLKRIHVEASAVTE 125
                 ..|..|...|  .||       :|       .||.|:|  :.|..::||:   ..|.:||
Worm    82 REIKKDQIPMLDTGE--NPDAPLPREMIDLEATFEKLENELRE--VNKNEETLKK---NFSELTE 139

  Fly   126 --HYYR--------LDSRRNRMME-----HSFALNKANKYMVSDMGSELLYSESTVIGLVQDATT 175
              |..|        :|..|.|::|     ...:..:.....:.|:|.           :..|:..
Worm   140 LKHILRKTQTFFEEVDHDRWRILEGGSGRRGRSTEREETRPLIDIGD-----------MDDDSAA 193

  Fly   176 TSGAYPA--HLNYMIGCIRADKFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFA 238
            ...|..|  .|.::.|.|:.::..:||.||:|.|..|:.:|.||:...:.:...|   :.|.|..
Worm   194 RMSAQAAMLRLGFVAGVIQRERLPAFERLLWRACRGNVFLRTSEIDDVLNDTVTG---DPVNKCV 255

  Fly   239 ILMMASSTMIWPKVLKICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILE 303
            .::......:..||.|||..:...:|.||.:..:|.:....:...|.:::.||.:.:..|.::|.
Worm   256 FIIFFQGDHLKTKVKKICEGFRATLYPCPDTPQERREMSIGVMTRIEDLKTVLGQTQDHRHRVLV 320

  Fly   304 VAGRDLFIIRVNLRKALKVYDLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGG 368
            .|.::   :|:.|.|..|:..:.:.|.|.......:.|:|||:.|.:::..:::.|:.      |
Worm   321 AASKN---VRMWLTKVRKIKSIYHTLNLFNIDVTQKCLIAEVWCPIAELDRIKMALKR------G 376

  Fly   369 ADNIDSSDEDEMNDMKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRG 433
            .|...|.....:|.|:|                                |..||||.:.||||:|
Worm   377 TDESGSQVPSILNRMET--------------------------------NEAPPTYNKTNKFTKG 409

  Fly   434 FQNLIDAYGMADYKELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINAT 498
            |||::||||:|.|:|:||||||:|:|||||||||||:|||.:::|.:...|.|.:::|..:|
Worm   410 FQNIVDAYGIATYREINPAPYTMISFPFLFAVMFGDMGHGAIMLLAALFFILKEKQLEAARI--- 471

  Fly   499 SENEILNILYAGRYIILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCRYNETTVYDPAFHVTLDS 563
             ::||....:.|||:|.|||.||:|.|.:||.|.:|..|.|||||     :.|:.:......||.
Worm   472 -KDEIFQTFFGGRYVIFLMGAFSIYTGFMYNDVFSKSINTFGSSW-----QNTIPESVIDYYLDD 530

  Fly   564 SH---------PH-FYSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAA 618
            ..         |. .:.|:|||:|:||||.:...:.::..||:||||:::.||:||.||:.|:..
Worm   531 EKRSESQLILPPETAFDGNPYPIGVDPVWNLAEGNKLSFLNSMKMKMSVLFGIAQMTFGVLLSYQ 595

  Fly   619 NCVLMNRKADLILVVIPQMIFMLCLFGYLVFLIFYKWMSYG-------GHKPAPYNAACAPSVLI 676
            |.:......|:..:.||||||:..:|.||...|..||:.:|       |:|....|  ||||:||
Worm   596 NFIYFKSDLDIKYMFIPQMIFLSSIFIYLCIQILSKWLFFGAVGGTVLGYKYPGSN--CAPSLLI 658

  Fly   677 TFINMMLMKK------EDPVE---NC-LDYMYPNERMIEFALVGIAFCTIPILLAGKPIYLMRRR 731
            ..|||.:||.      :|..|   .| |...||.:..||..||.:|...:||:|..||.:|.||.
Worm   659 GLINMFMMKSRNAGFVDDSGETYPQCYLSTWYPGQATIEIILVVLALVQVPIMLFAKPYFLYRRD 723

  Fly   732 RKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSVDNEEEH-------EMSEIWIHSG 789
            ::..:......:..:.|::   |:.:...|.:......|....:...|       ||.::.::..
Worm   724 KQQSRYSTLTAESNQHQSV---RADINQDDAEVVHAPEQTPKPSGHGHGHGDGPLEMGDVMVYQA 785

  Fly   790 IHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLTKGFANTLPLYYGVPVLMATFFAWAI 854
            |||||.|||.|||||||||||||||||.|||||||.||....|  .|..|.|.......||.:..
Worm   786 IHTIEFVLGCVSHTASYLRLWALSLAHAQLSDVLWTMVFRNAF--VLDGYTGAIATYILFFIFGS 848

  Fly   855 LTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFNF 897
            |:|.|||:|||||||||.||||||||||||:||.|..|..|:|
Worm   849 LSVFILVLMEGLSAFLHALRLHWVEFQSKFYGGLGYEFAPFSF 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	309/928 (33%)
unc-32	NP_001023017.1	NtpI	40..892	CDD:224188	310/930 (33%)
unc-32	NP_001023017.1	V_ATPase_I	40..891	CDD:279793	309/928 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870