DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and vha-6

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_496436.1	Gene:	vha-6 / 174743	WormBaseID:	WBGene00006915	Length:	865	Species:	Caenorhabditis elegans

Alignment Length:	966	Identity:	307/966 - (31%)
Similarity:	464/966 - (48%)	Gaps:	196/966 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.:|||.|.|||:...:|:|:.|:.|:|..|..||.::.:|.......:..:|.:|.|:.|.::.
Worm     3 SIYRSEHMKLCQIFFQSESAYQCVAELGELGMAQFIDLNEEQNAYTRKFVNEVRRCDEMERKINF 67

  Fly    78 LHTYIVQLHVNEIFYPDVDRE----------------NRLKEK--DLAKYSDSLKRIHV---EAS 121
            :...|.:   :.:..||.|..                .:|:|:  .:.|....||..||   |..
Worm    68 VEDEITK---DLVPIPDYDEHIPAPQPKHMGEMEANLEKLEEELVQINKNCKVLKNNHVQLLEMK 129

  Fly   122 AVTEHYYRL---DSRRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGL-VQDATTTSGAYPA 182
            ||.||...|   .|:|...|..                ||....|:..|.. ::|..........
Worm   130 AVLEHVTSLLDPHSKREAAMSI----------------SEAARGEAGPISFGMKDEFDKPVKDEK 178

  Fly   183 HLNYMIGCIRADKFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTM 247
            .|.::.|.::..|..:||..|:||....:..:|.:    :.|....:..|...|...::..|...
Worm   179 ELKFVTGVVKRSKAIAFERFLWRLSRAKVFAKFIQ----IQEQTELFSNEFEDKCVFILFFSGEQ 239

  Fly   248 IWPKVLKICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFII 312
            :..||.|||..:....|..|.:.::|...:..:..:..:::.|:::....|.:.:..|.
Worm   240 LRAKVKKICDGFQAKCYTVPENPAERTKLLLNIKVQTTDMKAVIEKTLDYRSKCIHAAA------ 298

  Fly   313 RVNLRK----ALKVYDLMNRLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNID 373
             .||||    .||:..:.:.|.:.......:.|:||.::|.:|:.:|:..|...:..||
Worm   299 -TNLRKWGIMLLKLKSIFHTLNMFSVDVTQKCLIAECWVPEADIGQVKNSLHMGTIHSG------ 356

  Fly   374 SSDEDEMNDMKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLI 438
            |:....:|:|:|                                :..|||||:|||||:||||::
Worm   357 STVPAILNEMET--------------------------------DKYPPTYFKLNKFTQGFQNIV 389

  Fly   439 DAYGMADYKELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEI 503
            ||||:|:|:|:||||:|||:|||||||||||.||||::::.:|..:    ..||..|:...::||
Worm   390 DAYGIANYREVNPAPWTIISFPFLFAVMFGDAGHGIIMLIAASAFV----IFEKKLISMKIKDEI 450

  Fly   504 LNILYAGRYIILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCRYNETTVYD-----PAFHVTLDS 563
            .|..:.|||::||||:|::|.|.:||...:|..|:|||||...||:|.:.:     ...:..|..
Worm   451 FNTFFGGRYVVLLMGMFAIYTGFIYNDFYSKSVNIFGSSWVNPYNQTLLANMDAQGADSNTDLSL 515

  Fly   564 SHP------HFYSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVL 622
            :.|      |.|.  |||.|:||||.: ..:.:...|.:|||.:|:||||||.||:.|:..|.:.
Worm   516 TFPPEIAFNHDYG--PYPFGVDPVWNL-AINRLNFLNPMKMKTSILLGISQMAFGIMLSLMNHIG 577

  Fly   623 MNRKADLILVVIPQMIFMLCLFGYLVFLIFYKWMSYGGHKPAPY-------NAACAPSVLITFIN 680
            .....|::.|.|||.:|:.|:|.||...:..||:.: ..||| |       .:.||||:||..||
Worm   578 NRSVVDIVFVFIPQCLFLGCIFVYLCLQVLMKWIFF-YVKPA-YIFGRLYPGSNCAPSLLIGLIN 640

  Fly   681 MMLMKKEDPV--------------------------ENC-LDYMYPNERMIEFALVGIAFCTIPI 718
            |.::|..|..                          :.| |...|||:.::|..|:.||..::|:
Worm   641 MFMVKSRDASFAHDVGTAAGKEWVIVNGQNVTYTINDQCYLQQWYPNQSLVELILLLIAVVSVPV 705

  Fly   719 LLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSVD---NEEEH- 779
            :|..||.|:..|.                                    ||...:|   ..:||
Worm   706 MLLVKPFYIRWRH------------------------------------SRGLHIDLGHGPDEHG 734

  Fly   780 --EMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLTKGFANTLPLYYG- 841
              ...:|.:|..|||||.|||.|||||||||||||||||.|||||||.|||....  |:..:.|
Worm   735 EFNFGDIMVHQAIHTIEFVLGCVSHTASYLRLWALSLAHAQLSDVLWTMVLRMSL--TMGGWGGS 797

  Fly   842 VPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFNF 897
            ..:.:..:|.::||:|.||::|||||||||.:|||||||||||:||.|..|:.|.|
Worm   798 AAITILFYFIFSILSVCILILMEGLSAFLHAIRLHWVEFQSKFYGGTGIQFEPFCF 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	295/939 (31%)
vha-6	NP_496436.1	NtpI	28..858	CDD:224188	296/941 (31%)
vha-6	NP_496436.1	V_ATPase_I	28..853	CDD:279793	295/939 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820