DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and Atp6v0a4

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_536715.3	Gene:	Atp6v0a4 / 140494	MGIID:	2153480	Length:	833	Species:	Mus musculus

Alignment Length:	915	Identity:	319/915 - (34%)
Similarity:	498/915 - (54%)	Gaps:	124/915 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||:|.|.|:.|..|.|:.|:.|:|..|.|||.::..........:..:|.:|..|.||:..
Mouse     3 SVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLERILRF 67

  Fly    78 LHTYIVQLHVNEIF--YPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRMMEH 140
            |...:    .|||.  .|:.|.|..| .:::.....:|:::..|.....:.:..|......:.|.
Mouse    68 LEDEM----QNEILIQVPEKDAETPL-PREMITLETTLEKLEGELQEANQSHQALKKSFLELTEL 127

  Fly   141 SFALNKANKYMVSD--MGSELLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADKFYSFELLL 203
            .:.|.|...:..::  :|.:....:::  ||: :..|........|.:..|.|..::..|||.||
Mouse   128 KYLLKKTQDFFETETNLGEDFFVEDTS--GLL-ELRTIPAFMTGKLGFTAGVINRERMASFERLL 189

  Fly   204 YRLCSFNLIIRFSEMPS----PVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHVNIY 264
            :|:|..|:.::||||.:    ||.:       |.::|...::......:..|:.|||..:...||
Mouse   190 WRVCRGNVYLKFSEMDTLLEDPVTK-------EEIKKNIFIIFYQGEQLRLKIKKICDGFRATIY 247

  Fly   265 DCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRD--LFIIRVNLRKALKVYDLMN 327
            .||..|::|.:.:..::..:.::..|:.:.|..|:::|:.|..:  .::|:|...||  ||.::|
Mouse   248 PCPEHAAERREMLTSVNVRLEDLITVITQTESHRQRLLQEAAANWHSWVIKVQKMKA--VYHVLN 310

  Fly   328 RLRLVGGVEVPRY-LLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNTTP 391
                :..::|.:. ::||::.|.:|...::..|.....:||                     ::.
Mouse   311 ----MCNIDVTQQCIIAEIWFPVADTRHIKKALEQGMELSG---------------------SSM 350

  Fly   392 YPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTI 456
            .||..:.:...|                 |||:.|.||||.||||::||||:..|:|:|||||||
Mouse   351 IPIMTEVETKTD-----------------PPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTI 398

  Fly   457 ITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVFS 521
            |||||||||||||.|||:::::.:..|:..    |::.:...|.||:.||.:.|||:|||||:||
Mouse   399 ITFPFLFAVMFGDCGHGMVMLMAALWMVLN----ERHLLAQKSTNEMWNIFFNGRYLILLMGIFS 459

  Fly   522 VYMGLVYNIVMAKGFNLFGSSWSCR-------YNETTVYDPAFHVTLDSSHPHFYSGHPYPLGMD 579
            :|.||:||...:|.||:||||||.:       :| |.:.:.:.::.||.:.|..|||:|||.|:|
Mouse   460 IYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWN-THIVENSPYLQLDPAIPGVYSGNPYPFGID 523

  Fly   580 PVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFMLCLF 644
            |:|.: ..:.:|..||.||||:::|||:.|:||:.|:..|.:...|..::||..||:|||||.||
Mouse   524 PIWNL-ASNKLTFLNSYKMKMSVILGIAHMIFGVILSLFNHIYFRRTLNIILQFIPEMIFMLSLF 587

  Fly   645 GYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIEFALV 709
            |||||:|.:||..|..|     .:..|||:||.||.|.|...:|.....|   |.:::.::...|
Mouse   588 GYLVFMIIFKWCRYDAH-----TSRKAPSILIHFIGMFLFDYDDSSNAPL---YGHQQEVQTFFV 644

  Fly   710 GIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSV- 773
            .||..::|.:|..||..|..:.:|.|         ::..||.|     ...:.|:|..|.:|:.
Mouse   645 IIALVSVPWMLLIKPFVLRAKHQKSQ---------LQSFTIHE-----DAVEGDHSGHSSKKTAG 695

  Fly   774 ------DNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLT--- 829
                  .:|||....:|::|..|||||..||.:|:||||||||||||||.:||:|||.||::
Mouse   696 AHGMKDGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAELSEVLWTMVMSIGL 760

  Fly   830 --KGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESF 892
              :|:|..:    ||.::.|.|   |:||||||::|||||||||.|||||||||:||:.|||..|
Mouse   761 RLQGWAGLV----GVFIIFAVF---AVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYEGAGSKF 818

  Fly   893 KAFNF 897
            ..|:|
Mouse   819 SPFSF 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	306/888 (34%)
Atp6v0a4	NP_536715.3	NtpI	28..824	CDD:224188	307/890 (34%)
		V_ATPase_I	28..823	CDD:279793	306/888 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	681..700		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780