DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and Atp6v0a1

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	XP_006532112.1	Gene:	Atp6v0a1 / 11975	MGIID:	103286	Length:	870	Species:	Mus musculus

Alignment Length:	939	Identity:	320/939 - (34%)
Similarity:	499/939 - (53%)	Gaps:	139/939 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYEL---LRIVD 76
            ||||:|.|.||.|.:|.|:.|:.|:|..|.|||.::..:..:....:..:|.:|.|:   ||.|:
Mouse     5 FRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVE 69

  Fly    77 ----SLHTYIVQLHVN-EIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNR 136
                ..:..|:....| |:.:|   |:....|.:..|..:.||.|:....|:..::..|
Mouse    70 KEIRKANIPIMDTGENPEVPFP---RDMIDLEANFEKIENELKEINTNQEALKRNFLEL------ 125

  Fly   137 MMEHSFALNKANKYM------VSDMGSELLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADK 195
             .|..|.|.|..::.      ...|....|..||:  .|::......|| |..|.::.|.|..::
Mouse   126 -TELKFILRKTQQFFDEAELHHQQMADPDLLEESS--SLLEPNEMGRGA-PLRLGFVAGVINRER 186

  Fly   196 FYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYH 260
            ..:||.:|:|:|..|:.:|.:|:.:|:.:...|   :.|.|...::......:..:|.|||..:.
Mouse   187 IPTFERMLWRVCRGNVFLRQAEIENPLEDPVTG---DYVHKSVFIIFFQGDQLKNRVKKICEGFR 248

  Fly   261 VNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALKVYDL 325
            .::|.||.:..:|::....::..|.:::.||.:.|..|:::|:.|.:::.:..:.:||...:|..
Mouse   249 ASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHT 313

  Fly   326 MNRLRLVGGVEV-PRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNT 389
            :|    :..::| .:.|:|||:.|.:|:..::..||..:..||                    :|
Mouse   314 LN----LCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSG--------------------ST 354

  Fly   390 TPYPIEADFQPLEDMSAGAILLKKNRL-VNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAP 453
            .|                :||   ||: .|..||||.:.||||.||||::||||:..|:|:||||
Mouse   355 VP----------------SIL---NRMQTNQTPPTYNKTNKFTHGFQNIVDAYGIGTYREINPAP 400

  Fly   454 YTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMG 518
            ||:|||||||||||||.|||||:.||:..|:.:...|    ::...|||:.:::::|||||||||
Mouse   401 YTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRI----LSQKHENEMFSMVFSGRYIILLMG 461

  Fly   519 VFSVYMGLVYNIVMAKGFNLFGSSWSCR-------YNETTVYDPAFHVTLDSSHPHFYSGHPYPL 576
            :||:|.||:||...:|..|:||||||.|       :.|.|:...:. :.|:.:.|..:.| |||.
Mouse   462 LFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTQGNWTEETLLGSSV-LQLNPAIPGVFGG-PYPF 524

  Fly   577 GMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFML 641
            |:||:|.: ..:.:|..||.||||:::|||..|:||:.|:..|.:...:..::....||::|||.
Mouse   525 GIDPIWNI-ATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMS 588

  Fly   642 CLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIEF 706
            .||||||.||||||.:|..|     ::..|||:||.||||.|....:. .|.:  :|..::.|:.
Mouse   589 SLFGYLVILIFYKWTAYDAH-----SSRNAPSLLIHFINMFLFSYPES-GNAM--LYSGQKGIQC 645

  Fly   707 ALVGIAFCTIPILLAGKPIYL----MRRRRKMQQERERDFKRMRRQTIAE----MRSTMRY---- 759
            .|:.:|...:|.:|..||:.|    :|::....|..|........|...|    ...|:.:
Mouse   646 FLIVVAMLCVPWMLLFKPLILRHQYLRKKHLEGQPVEAPVTPTPSQQGLEAAPAATGTLNFGGIR 710

  Fly   760 -----TDDD-----------NSETSRQKSVDNEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLR 808
                 |::|           :||.:.:.:.|  |..:..:..:|..|||||..||.:|:||||||
Mouse   711 VGNGPTEEDAEIIQHDQLSTHSEDAEEPTED--EVFDFGDTMVHQAIHTIEYCLGCISNTASYLR 773

  Fly   809 LWALSLAHDQLSDVLWHMVL-----TKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSA 868
            ||||||||.|||:|||.||:     .:..|..|.|::       .|.|:|.||||||::||||||
Mouse   774 LWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFF-------IFAAFATLTVAILLIMEGLSA 831

  Fly   869 FLHTLRLHWVEFQSKFFGGAGESFKAFNF 897
            |||.|||||||||:||:.|.|..|..|:|
Mouse   832 FLHALRLHWVEFQNKFYTGTGFKFLPFSF 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	307/914 (34%)
Atp6v0a1	XP_006532112.1	V_ATPase_I	27..860	CDD:366676	307/915 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.730