DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and Atp6v0a2

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_446227.2	Gene:	Atp6v0a2 / 116455	RGDID:	621006	Length:	856	Species:	Rattus norvegicus

Alignment Length:	939	Identity:	320/939 - (34%)
Similarity:	479/939 - (51%)	Gaps:	153/939 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||.|.|.||.|.:..|::||..:|..|.|||.::..........:..:|.:|.||.||:
  Rat     3 SLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERIL-- 65

  Fly    78 LHTYIVQLHVNEIFYPDVDRENRLKE----------KDLAKYSDSLKRIHVEASAVTEHYYRLDS 132
              .|:||    ||...|:.    |.|          |.:.:..:.|:::.||...||::..:|..
  Rat    66 --VYLVQ----EITRADIP----LPEGEASPPAPPVKHVLEMQEQLQKLEVELREVTKNKEKLRK 120

  Fly   133 RRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYP---AHLNYMIGCIRAD 194
            ....::|::..|.....::..::..|..|.|..  .|..|:........   |.|.::.|.|:..
  Rat   121 NLLELVEYTHMLRVTKTFLKRNVEFEPTYEEFP--ALESDSLLDYSCMQRLGAKLGFVSGLIQQG 183

  Fly   195 KFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHY 259
            |..:||.:|:|.|....|:.::|:...:.:...|   |.::.:..|:......|..||.|||..|
  Rat   184 KVEAFERMLWRACKGYTIVTYAELDEALEDPETG---EVIKWYVFLISFWGEQIGHKVKKICDCY 245

  Fly   260 HVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALKVYD 324
            |.:||..|::|.:|.:..:.|:..|.::..||.:.|...||:|..|...:....:.:||...:|.
  Rat   246 HCHIYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVCSRVIQVRKMKAIYH 310

  Fly   325 LMNRLRLVGGVEVP-RYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMP- 387
            ::|    :...:|. :.|:|||:.|..|:|.:...|...||.||.                |:|
  Rat   311 MLN----MCSFDVTNKCLIAEVWCPEVDLPGLRRALEEGSRESGA----------------TIPS 355

  Fly   388 --NTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELN 450
              ||.|                         ....|||..|.||||.||||::||||:..|:|:|
  Rat   356 FMNTIP-------------------------TKETPPTLIRTNKFTEGFQNIVDAYGVGSYREVN 395

  Fly   451 PAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIW--KHREIEKYQINATSENEILNILYAGRYI 513
            ||.:|||||||||.|||||||||.::.||:.|::.  .|..:.:.|       |||.:.:.||||
  Rat   396 PALFTIITFPFLFGVMFGDLGHGFVMFLFALLLVLNENHPRLSQSQ-------EILRMFFDGRYI 453

  Fly   514 ILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCR-----------------YNETTVYDPAFH--- 558
            :||||:||||.||:||...:|..|||||.|:..                 :|::|:.    |
  Rat   454 LLLMGLFSVYTGLIYNDCFSKSLNLFGSGWNVSAMYSSSHSPEEQRKMVLWNDSTIR----HSRT 514

  Fly   559 VTLDSSHPHFYSGHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLM 623
            :.||.:.|..:.| |||.|:||:|.: ..:.:|..||.||||:::|||..|.||:.|...|.:..
  Rat   515 LQLDPNIPGVFRG-PYPFGIDPIWNL-ATNRLTFLNSFKMKMSVILGIFHMTFGVILGIFNHLHF 577

  Fly   624 NRKADLILVVIPQMIFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKED 688
            .:|.::.||.:|:::||||:||||:|:|.|||::|...     .:..|||:||.||||.|....:
  Rat   578 RKKFNIYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAE-----TSREAPSILIEFINMFLFPSSE 637

  Fly   689 PVENCLDYMYPNERMIEFALVGIAFCTIPILLAGKPIYL--MRRRRK-----------MQQERER 740
                 ...:||.:..::..|:.:....:|:|..|||::|  :...|.           ::::.|.
  Rat   638 -----THGLYPGQAHVQKVLLALTVLAVPVLFLGKPLFLLWLHNGRSCFGVSRSGYTLVRKDSEE 697

  Fly   741 DFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSVDNEEEHEMSEIWIHSGIHTIETVLGSVSHTAS 805
            :...:..|.|.|..:.|       .|..|:.:.   ||....||.:...||:||..||.:|:|||
  Rat   698 EVSLLGSQDIEEGNNRM-------EEGCREMTC---EEFNFGEILMTQAIHSIEYCLGCISNTAS 752

  Fly   806 YLRLWALSLAHDQLSDVLWHMVLTKGFA--NTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSA 868
            |||||||||||.|||||||.|::..|..  ||    |||.:|:.....:|:|||.||::||||||
  Rat   753 YLRLWALSLAHAQLSDVLWAMLMRVGLRVDNT----YGVLLLLPVMTFFAVLTVFILLVMEGLSA 813

  Fly   869 FLHTLRLHWVEFQSKFFGGAGESFKAFNF 897
            |||.:||||||||:||:.|||..|..|:|
  Rat   814 FLHAIRLHWVEFQNKFYVGAGTKFVPFSF 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	306/912 (34%)
Atp6v0a2	NP_446227.2	NtpI	5..839	CDD:224188	317/932 (34%)
Atp6v0a2	NP_446227.2	V_ATPase_I	28..839	CDD:279793	305/909 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010