DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and TCIRG1

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	XP_024304088.1	Gene:	TCIRG1 / 10312	HGNCID:	11647	Length:	861	Species:	Homo sapiens

Alignment Length:	977	Identity:	260/977 - (26%)
Similarity:	402/977 - (41%)	Gaps:	207/977 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||::.|.||.|.|..|:.|:..:|..|.|:|.::..........:...|.:|.||.:....
Human     3 SMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTFTF 67

  Fly    78 LHTYIVQLHVNEIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRMMEHSF 142
            |...:.:..:  :..|...|......:||.:..:..:|:..|...|..:...|.::.:::..|:.
Human    68 LQEEVRRAGL--VLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLHAA 130

  Fly   143 ALNKANKYMV----SDMGSE---LLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADKFYSFE 200
            .|.:.::..:    :|..||   ||.:..   |..||         ..:|::.|.:...|..:.|
Human   131 VLRQGHEPQLAAAHTDGASERTPLLQAPG---GPHQD---------LRVNFVAGAVEPHKAPALE 183

  Fly   201 LLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHVNIYD 265
            .||:|.|...||..|.|:..|: |:....:|.....|.|.....  .|..|:.||.        |
Human   184 RLLWRACRGFLIASFRELEQPL-EHPVTGEPATWMTFLISYWGE--QIGQKIRKIT--------D 237

  Fly   266 CPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAG---------------------RDL 309
            |.||.                      :..|.|..:....|                     .|.
Human   238 CASSL----------------------QLPLPRLPVSAAGGGPPRGPAAAATAEPGAAGGPRGDR 280

  Fly   310 FIIRVNLRKALKVYDL------MNRLRLVGGVEVPRYLLAEVYIPSSDVPEVE--VILRNASRIS 366
            .:.....|........      .:..|:.|...|.|...|:       ||...  |:....:|.:
Human   281 AVPEPGARPGAAAAAARAGAGPQDEGRVPGPEPVQREHHAQ-------VPHCRGLVLCARPARPA 338

  Fly   367 GG-ADNIDSSDEDEMNDMKTMPNTTPYPIEADFQPLEDMSAG-AILLKKNRLV---------NHM 420
            || |..:|....:.......:|...|:  ....|||.....| ...|::..|.         :|:
Human   339 GGPAGQLDGGGSECRGSPHPLPGHAPH--THPHQPLHGQLPGHRGCLRRGPLPGGQPRSLHHHHL 401

  Fly   421 P----------------------------PTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTII 457
            |                            ||         |.:...:. .:||:.: .|.|
Human   402 PLPVCCDVRGCGPRAAHVPVRPGHGPCGEPT---------GCEGRAER-DLADFLQ-GPLP---- 451

  Fly   458 TFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVFSV 522
                  |..:|.:.|             .|| :...::..:....:...|..||:
Human   452 ------APAYGPVLH-------------LHR-LHLQRVLQSRHQHLPLGLECGRH---------- 486

  Fly   523 YMGLVYNIVMAKGFNLFGSSWSCRYNETTVYDP---------AFH--VTLDSSHPHFYSGHPYPL 576
              |....:.:..|..   ..|..|...:....|         |.|  :|||.:....:.| |||.
Human   487 --GQPVWLEVRPGPQ---PGWGPRSTRSPDRPPLRCRSDAFLAQHTMLTLDPNVTGVFLG-PYPF 545

  Fly   577 GMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFML 641
            |:||:|::.. :.::..||.||||:::||:..|.||:.|...|.|...::..|:|..:|::.|:|
Human   546 GIDPIWSLAA-NHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHFGQRHRLLLETLPELTFLL 609

  Fly   642 CLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIEF 706
            .||||||||:.|||:.....:     ||.|||:||.||||.|. ...|....|   ||.:.:::.
Human   610 GLFGYLVFLVIYKWLCVWAAR-----AASAPSILIHFINMFLF-SHSPSNRLL---YPRQEVVQA 665

  Fly   707 ALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQK 771
            .||.:|...:||||.|.|::|:.|.|:..:.|..|.:...:..:.::....  .:..:|:..:..
Human   666 TLVVLALAMVPILLLGTPLHLLHRHRRRLRRRPADRQEENKAGLLDLPDAS--VNGWSSDEEKAG 728

  Fly   772 SVDNEEEHEM--SEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLTKGFAN 834
            .:|:|||.|:  ||:.:|..|||||..||.||:||||||||||||||.|||:|||.||:..|...
Human   729 GLDDEEEAELVPSEVLMHQAIHTIEFCLGCVSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGL 793

  Fly   835 TLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFNFPT 899
            ...:.....||:..|.|:|::|||||::|||||||||.|||||||||:||:.|.|.....|.|..
Human   794 GREVGVAAVVLVPIFAAFAVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSPFTFAA 858

  Fly   900 SN 901
            ::
Human   859 TD 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	247/946 (26%)
TCIRG1	XP_024304088.1	V_ATPase_I	27..>238	CDD:332370	48/235 (20%)
		SelP_N	<357..400	CDD:309645	8/44 (18%)
		V_ATPase_I	<541..856	CDD:332370	142/327 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750