DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-3 and atp6v0a4

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	NP_001107162.1	Gene:	atp6v0a4 / 100135019	XenbaseID:	XB-GENE-493197	Length:	846	Species:	Xenopus tropicalis

Alignment Length:	917	Identity:	315/917 - (34%)
Similarity:	491/917 - (53%)	Gaps:	115/917 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77
            |.||||:|.|.||:|..|..:.|:.|:|..|.|||.::..........:..:|.:|..:.||:..
Frog     3 SLFRSEEMSLTQLILQVEAGYCCIAELGELGLVQFRDLNASVNSFQRRFVNEVRRCENMERILRF 67

  Fly    78 LHTYIVQLHVNEIFYPD------VDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNR 136
            |.:.:|...: :|..|:      :.||....|..|.|....|:.::....|:.:::..|..
Frog    68 LESEMVNDKI-KIRTPEKLPQTPLPREMIDLETVLEKLEGELQEVNRNQQALKQNFLELTE---- 127

  Fly   137 MMEHSFALNKANKYMVSDMG-SELLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADKFYSFE 200
             ::|  .|.|...:..::.. .:..:||.| ..|::..|..|.|....|.:..|.|..::..:||
Frog   128 -LKH--LLKKTQDFFEAEANLPDDFFSEDT-SSLLELRTIPSAAAAGKLGFTAGVINRERMATFE 188

  Fly   201 LLLYRLCSFNLIIRFSEMPS----PVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHV 261
            .||:|:|..|:.::::|:.:    ||.:       |.|:|...::......:..|:.|||..:..
Frog   189 RLLWRVCRGNIYLKYTELDTALEDPVTK-------EEVKKNVFIIFYQGDQLKLKIKKICDGFKA 246

  Fly   262 NIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIRVNLRKALKVYDLM 326
            .:|.||.||::|::.|.:::..|.::..|:.:.|..|:::|..|.:.|....:.::|...||.::
Frog   247 TVYPCPESATERKEMVADVNTRIEDLNTVITQTESHRQRVLLEAAQSLCSWGIKVKKMKAVYHVL 311

  Fly   327 NRLRLVGGVEVPRY-LLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNTT 390
            |    :..::|.:. ::||::.|.:|..:::..|......||                     :|
Frog   312 N----LCNIDVTQQCVIAEIWCPIADKEQIKQALHRGMERSG---------------------ST 351

  Fly   391 PYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYT 455
            ..||..:.....|                 |||:.|.||||.||||:::|||:..|:|:||.|||
Frog   352 IAPILTNISSKLD-----------------PPTFNRTNKFTSGFQNIVNAYGVGSYREMNPTPYT 399

  Fly   456 IITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVF 520
            ||||||||||||||.|||.:::.|:..|:..    ||..:.:.::|||.|..:.|||:||||.:|
Frog   400 IITFPFLFAVMFGDCGHGSVMLGFALWMVLN----EKQLLASKTDNEIWNTFFGGRYLILLMSIF 460

  Fly   521 SVYMGLVYNIVMAKGFNLFGSSWSCR-------YNETTVYDPAFHVTLDSSHPHFYSGHPYPLGM 578
            |:|.|.:||...:|.|::|||||..|       :|:..|:. ...:.||.:.|..|||:|||.|:
Frog   461 SIYTGFIYNDCFSKSFDIFGSSWRVRPMFINKTWNDNLVHQ-GLQLQLDPAVPGVYSGNPYPFGI 524

  Fly   579 DPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFMLCL 643
            ||:|.: .|:.:|..||.||||::|:||:||:||:.|...|.:...|..::||..:|:|||::||
Frog   525 DPIWNI-AQNKLTFLNSYKMKMSVVMGITQMVFGVMLGLLNHINFKRPINIILQFVPEMIFIICL 588

  Fly   644 FGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIEFAL 708
            ||||||:|.:||..|..|     ::..|||:||.||||.|....||....|   |.:::.::..|
Frog   589 FGYLVFMIIFKWCKYDVH-----SSQGAPSILIHFINMFLFNYSDPTNAPL---YEHQKEVQTFL 645

  Fly   709 VGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSV 773
            |..|...:|.:|..||..|.....|.|        || .|:.:........||.:|:..:.:...
Frog   646 VIFALIAVPWMLLIKPFVLRANHLKAQ--------RM-LQSSSGPEDHAELTDVENAHANHKSKK 701

  Fly   774 DNE-------------EEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWH 825
            :..             ||.:..:|::|..|||||..||.:|:||||||||||||||.|||:|||.
Frog   702 EEHGGGDHGGGHGEHGEEFDFGDIFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWT 766

  Fly   826 MVLTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGE 890
            ||:.:|.  ::..|.|:..:...|.|:|:||||||::|||||||||.|||||||||:||:.|.|.
Frog   767 MVMHQGL--SIGGYGGLIGVFIIFAAFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYAGTGH 829

  Fly   891 SFKAFNF 897
            .|..|:|
Frog   830 LFSPFSF 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	302/890 (34%)
atp6v0a4	NP_001107162.1	NtpI	26..838	CDD:224188	303/894 (34%)
atp6v0a4	NP_001107162.1	V_ATPase_I	28..836	CDD:279793	302/890 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11629
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.110