Protein Alignment Vha100-3 and tcirg1a

DIOPT Version :10

• Sequence 1: NP_725837.1
• Gene: Vha100-3 / 246543
• FlyBaseID: FBgn0028669
• Length: 904
• Species: Drosophila melanogaster
• Sequence 2: XP_005160329.1
• Gene: tcirg1a / 100003139
• ZFINID: ZDB-GENE-090311-31
• Length: 823
• Species: Danio rerio
• Alignment Length: 915
• Identity: 309/915 - (33%)
• Similarity: 472/915 - (51%)
• Gaps: 135/915 - (14%)

  Fly    15 FRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDSLH 79
            ||||:|.|.|:.|...:|::|:.|:|..|.|:|.::..........:..:|.:|.||    :...
Zfish     5 FRSEEMCLVQIFLQAGSAYNCVSELGELGLVEFRDLNPNVNAFQKKFVSEVRRCEEL----EKTF 65

  Fly    80 TYIVQLHVNEIFYPDVDR--------ENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNR 136
            .|:.| .::...||.:..        .:..:.::|....:..:|:..|...|:.:   .||.||:
Zfish    66 KYLEQ-EISRSLYPPLKGALPTASPIPSAPQPRELLCIEEESERLARELREVSRN---RDSLRNQ 126

  Fly   137 MMEHS--FALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADKFYSF 199
            :.:.|  ..:.|.:..:.:.....|....|.::...||         ..|:::.|.:...|..:|
Zfish   127 LTQLSQYRGVLKQSILLPTSQVPPLTLETSALLDSRQD---------MRLSFVAGVVHPWKVPAF 182

  Fly   200 ELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHVNIY 264
            |.||:|.|...:|:.|.||...:.|...|   |.::....::......|..||.|||..:..:.:
Zfish   183 ERLLWRACRGYIIVDFWEMEERLEEPDTG---ETIQWTVFVISFWGEQIGQKVKKICDCFRTHTF 244

  Fly   265 DCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILE--VAGRDLFIIRVNLRKALKVYDLMN 327
            ..|....:||..::.|...||::..||.:.|...:|:|.  |.....:.|||...||:::.
Zfish   245 VYPEGLEEREGILQGLESRIVDIRTVLSQTEQYMQQLLSRCVCQMPQWKIRVQKCKAVQMV---- 305

  Fly   328 RLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNTTPY 392
             |.|.......:.|:||.:.|.:.:..::..|...:|.||  .::||           ..|..|.
Zfish   306 -LNLCSPSVTDKCLIAEAWCPVAKLLLLQSALMEGTRKSG--SSVDS-----------FYNRLPA 356

  Fly   393 PIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTII 457
            |..                         |||.|..|.||..|||::||||:|.|:|:|||.||||
Zfish   357 PTS-------------------------PPTLFETNAFTSSFQNIVDAYGVASYREVNPAVYTII 396

  Fly   458 TFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVFSV 522
            ||||||||||||:|||:|:.|.:..||.:.|:.:.    .||.|||..:|:.|||:||:||:||:
Zfish   397 TFPFLFAVMFGDVGHGLLMTLAALWMILEERDPKM----RTSTNEIWRMLFGGRYLILMMGLFSI 457

  Fly   523 YMGLVYNIVMAKGFNLFGSSWSCR-----YN---ETTVYDPAFHVTLDSSHPHFYSGHPYPLGMD 579
            |.|.:||...:||.:...|.|..:     ||   ||...:.  ::|||.:....:.| |||.|:|
Zfish   458 YTGAIYNECFSKGLSPVSSGWHLKPMIQHYNWSDETLRSNQ--YLTLDPNITGVFQG-PYPFGID 519

  Fly   580 PVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFMLCLF 644
            |:|:: ..:.:|..||.||||::::|:..|.||:.|:..|.:.....:.:.||:||:::||||||
Zfish   520 PIWSL-ANNHLTFLNSYKMKMSVIIGVIHMTFGVCLSFFNYMYFGNVSSVFLVLIPELVFMLCLF 583

  Fly   645 GYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIEFALV 709
            |||||::.:||:::|     |.::..|||:||.||:|.|. .|:|....|   ||.:..::..||
Zfish   584 GYLVFMVVFKWIAFG-----PQDSDRAPSILIHFIDMFLF-SENPSNPPL---YPRQMTVQRILV 639

  Fly   710 GIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSVD 774
            .:|...:|:||.|||:.|..:.|           ..||....|.||.:..|...|::.     ||
Zfish   640 CLALLAVPVLLLGKPLQLYFQHR-----------NSRRTLHEEQRSLVTDTSSINAQL-----VD 688

  Fly   775 -------NEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLT--- 829
                   :|:|.|.:|:::...|||||..||.:|:||||||||||||||.||::|||.||:.
Zfish   689 LEGGGGIDEQEFEWTEVFMQQAIHTIEYCLGCISNTASYLRLWALSLAHAQLAEVLWVMVMRISL 753

  Fly   830 --KGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESF 892
              :|       |.|..||...|..:|.|||:||::|||||||||.|||||||||:||:.|:|..|
Zfish   754 SWQG-------YVGSVVLSVVFSLFATLTVSILLVMEGLSAFLHALRLHWVEFQNKFYRGSGYKF 811

  Fly   893 KAFNF 897
            ..|:|
Zfish   812 NPFSF 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:460232	298/890 (33%)
tcirg1a	XP_005160329.1	V_ATPase_I	27..816	CDD:460232	298/891 (33%)