DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-3 and tcirg1a

DIOPT Version :9

Sequence 1:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster
Sequence 2:	XP_005160329.1	Gene:	tcirg1a / 100003139	ZFINID:	ZDB-GENE-090311-31	Length:	823	Species:	Danio rerio

Alignment Length:	915	Identity:	309/915 - (33%)
Similarity:	472/915 - (51%)	Gaps:	135/915 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDSLH 79
            ||||:|.|.|:.|...:|::|:.|:|..|.|:|.::..........:..:|.:|.||    :...
Zfish     5 FRSEEMCLVQIFLQAGSAYNCVSELGELGLVEFRDLNPNVNAFQKKFVSEVRRCEEL----EKTF 65

  Fly    80 TYIVQLHVNEIFYPDVDR--------ENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNR 136
            .|:.| .::...||.:..        .:..:.::|....:..:|:..|...|:.:   .||.||:
Zfish    66 KYLEQ-EISRSLYPPLKGALPTASPIPSAPQPRELLCIEEESERLARELREVSRN---RDSLRNQ 126

  Fly   137 MMEHS--FALNKANKYMVSDMGSELLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADKFYSF 199
            :.:.|  ..:.|.:..:.:.....|....|.::...||         ..|:::.|.:...|..:|
Zfish   127 LTQLSQYRGVLKQSILLPTSQVPPLTLETSALLDSRQD---------MRLSFVAGVVHPWKVPAF 182

  Fly   200 ELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHVNIY 264
            |.||:|.|...:|:.|.||...:.|...|   |.::....::......|..||.|||..:..:.:
Zfish   183 ERLLWRACRGYIIVDFWEMEERLEEPDTG---ETIQWTVFVISFWGEQIGQKVKKICDCFRTHTF 244

  Fly   265 DCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILE--VAGRDLFIIRVNLRKALKVYDLMN 327
            ..|....:||..::.|...||::..||.:.|...:|:|.  |.....:.|||...||:::.
Zfish   245 VYPEGLEEREGILQGLESRIVDIRTVLSQTEQYMQQLLSRCVCQMPQWKIRVQKCKAVQMV---- 305

  Fly   328 RLRLVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSDEDEMNDMKTMPNTTPY 392
             |.|.......:.|:||.:.|.:.:..::..|...:|.||  .::||           ..|..|.
Zfish   306 -LNLCSPSVTDKCLIAEAWCPVAKLLLLQSALMEGTRKSG--SSVDS-----------FYNRLPA 356

  Fly   393 PIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTII 457
            |..                         |||.|..|.||..|||::||||:|.|:|:|||.||||
Zfish   357 PTS-------------------------PPTLFETNAFTSSFQNIVDAYGVASYREVNPAVYTII 396

  Fly   458 TFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVFSV 522
            ||||||||||||:|||:|:.|.:..||.:.|:.:.    .||.|||..:|:.|||:||:||:||:
Zfish   397 TFPFLFAVMFGDVGHGLLMTLAALWMILEERDPKM----RTSTNEIWRMLFGGRYLILMMGLFSI 457

  Fly   523 YMGLVYNIVMAKGFNLFGSSWSCR-----YN---ETTVYDPAFHVTLDSSHPHFYSGHPYPLGMD 579
            |.|.:||...:||.:...|.|..:     ||   ||...:.  ::|||.:....:.| |||.|:|
Zfish   458 YTGAIYNECFSKGLSPVSSGWHLKPMIQHYNWSDETLRSNQ--YLTLDPNITGVFQG-PYPFGID 519

  Fly   580 PVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFMLCLF 644
            |:|:: ..:.:|..||.||||::::|:..|.||:.|:..|.:.....:.:.||:||:::||||||
Zfish   520 PIWSL-ANNHLTFLNSYKMKMSVIIGVIHMTFGVCLSFFNYMYFGNVSSVFLVLIPELVFMLCLF 583

  Fly   645 GYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIEFALV 709
            |||||::.:||:::|     |.::..|||:||.||:|.|. .|:|....|   ||.:..::..||
Zfish   584 GYLVFMVVFKWIAFG-----PQDSDRAPSILIHFIDMFLF-SENPSNPPL---YPRQMTVQRILV 639

  Fly   710 GIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQKSVD 774
            .:|...:|:||.|||:.|..:.|           ..||....|.||.:..|...|::.     ||
Zfish   640 CLALLAVPVLLLGKPLQLYFQHR-----------NSRRTLHEEQRSLVTDTSSINAQL-----VD 688

  Fly   775 -------NEEEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLT--- 829
                   :|:|.|.:|:::...|||||..||.:|:||||||||||||||.||::|||.||:.
Zfish   689 LEGGGGIDEQEFEWTEVFMQQAIHTIEYCLGCISNTASYLRLWALSLAHAQLAEVLWVMVMRISL 753

  Fly   830 --KGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESF 892
              :|       |.|..||...|..:|.|||:||::|||||||||.|||||||||:||:.|:|..|
Zfish   754 SWQG-------YVGSVVLSVVFSLFATLTVSILLVMEGLSAFLHALRLHWVEFQNKFYRGSGYKF 811

  Fly   893 KAFNF 897
            ..|:|
Zfish   812 NPFSF 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	298/890 (33%)
tcirg1a	XP_005160329.1	NtpI	5..818	CDD:224188	309/915 (34%)
tcirg1a	XP_005160329.1	V_ATPase_I	28..816	CDD:279793	298/890 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750