DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2b and SEMA5A

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_003957.2	Gene:	SEMA5A / 9037	HGNCID:	10736	Length:	1074	Species:	Homo sapiens

Alignment Length:	809	Identity:	240/809 - (29%)
Similarity:	337/809 - (41%)	Gaps:	212/809 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 WNLYYEPPCCTGSSAAHHLRH----HKE-----------HVQDFSCGPLHYKTFYMDERNNALYV 136
            |.|.:  |...|::......|    :||           :..|||     ..||  |.....|.|
Human    17 WRLAH--PEAQGTTQCQRTEHPVISYKEIGPWLREFRAKNAVDFS-----QLTF--DPGQKELVV 72

  Fly   137 GAMDRIFRLNLRNIS--QSI---CERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNFN 196
            ||.:.:|||.|.::|  |::   |:      |.|..   .|.|||| .|.||:|:|||:.   ..
Human    73 GARNYLFRLQLEDLSLIQAVEWECD------EATKK---ACYSKGK-SKEECQNYIRVLL---VG 124

  Fly   197 GQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPA 261
            |.:|:.|||||..|  ...|.:|::|  ::....|. |:.:|||.|..||||:....|.
Human   125 GDRLFTCGTNAFTP--VCTNRSLSNL--TEIHDQIS-GMARCPYSPQHNSTALLTAGGE------ 178

  Fly   262 LYAGTNAEFTKADSVIFRS--DLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFVYFFF 324
            |||.|..:|...|..|:||  .|..|          ||.:|:||.|::||||.|::||.|.||||
Human   179 LYAATAMDFPGRDPAIYRSLGILPPL----------RTAQYNSKWLNEPNFVSSYDIGNFTYFFF 233

  Fly   325 REHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKM 389
            ||:|||: :|||.|:||.|||||||.||::::...|.|::|||:|||...|.|||:||:||.:.:
Human   234 RENAVEH-DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFL 297

  Fly   390 PTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRP--- 451
            |..|. .|..||||.|.:..||||.:::..|..||.|.||.|..|.|||||     .|.|.|
Human   298 PELDL-IYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLP-----YPNPNPHFQ 356

  Fly   452 -GTCHNDT-ATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLV 514
             ||..... ..|.:..|...:|..||.:.|......|.|.:.:...:.:.||.::    .:|.||
Human   357 CGTVDQGLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQ----GREALV 417

  Fly   515 Y--FVATTSGHIYKIVQFMHYGQRHSN-LVDIFEASP--HSEPIREMTLSHKTGSLYVATDHQVK 574
            :  ::||..|.|.|:  .:...|..|: |::..|..|  ..||||.:.:.|....|:|.....|.
Human   418 HIIYLATDYGTIKKV--RVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFVGLREHVV 480

  Fly   575 QIDIAMCARRYDSCFRCV--SDPYCGWDKDVNACRPYQLGLLQDVANETSGICDTSVLRKKVTSS 637
            :|.:..| :.|.:...|:  .|||||||..:..|...:..|......::...|.|..|
Human   481 KIPLKRC-QFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQWEQSISACPTRNL------- 537

  Fly   638 YGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEV--RYTPTKYIDTNEGGLVLLAVNEGD--- 697
                                        |..|.:.|  .:||..:.|.:..|..|......|
Human   538 ----------------------------TVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPA 574

  Fly   698 ---------------------GG--RYDSYLDGTLLCSYGVTVDAHRCSPPSQK--------QDY 731
                                 ||  .:.|:...:..|..|..|....||.|:.:        |:.
Human   575 PQCGGWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNR 639

  Fly   732 QKIYSHWCNEF-----EKYKSAMKQWQAKQEQCG------------------------------- 760
            ::.|   |||.     ..:.:....|:....|||
Human   640 EERY---CNEHLLCPPHMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPC 701

  Fly   761 --LKDKTGP--------ISSNGKHVNDVF 779
              || ||.|        ||.||.|....|
Human   702 PELK-KTTPWTPWTPVNISDNGGHYEQRF 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	177/475 (37%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	15/115 (13%)
SEMA5A	NP_003957.2	Sema_5A	50..485	CDD:200524	180/488 (37%)
		PSI	486..533	CDD:279745	12/47 (26%)
		TSP1	544..595	CDD:214559	7/50 (14%)
		TSP1	598..651	CDD:214559	12/55 (22%)
		TSP1	656..702	CDD:214559	4/45 (9%)
		TSP1	787..839	CDD:214559
		TSP1	844..896	CDD:214559
		TSP1	899..940	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810