DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema2b and SEMA6D

DIOPT Version :9

Sequence 1:NP_001261024.1 Gene:Sema2b / 246538 FlyBaseID:FBgn0264273 Length:824 Species:Drosophila melanogaster
Sequence 2:NP_001345281.1 Gene:SEMA6D / 80031 HGNCID:16770 Length:1086 Species:Homo sapiens


Alignment Length:823 Identity:231/823 - (28%)
Similarity:351/823 - (42%) Gaps:200/823 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 LCSLSALLLVLVAQTVHVEYARADYE-NTWNLYY--EPPCCTGSSAAHHLRHHKEHVQDFSCGPL 120
            ||:.  :||::|:|...|.:...|.. ||.:.:|  :.|...|..:.    :..:|..||.    
Human     6 LCAY--ILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSG----NESQHRLDFQ---- 60

  Fly   121 HYKTFYMDERNNALYVGAMDRIFRLNLRNISQS-ICERDVLILEPTGSDILNCVSKGKREKVECR 184
                 .|.:..:.||:...|:::.:||..:.:: :.....|.......|..||..||| .|.||.
Human    61 -----LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGK-HKDECH 119

  Fly   185 NHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAV 249
            |.|:|..|.  |.:.::||||||.||.     .....|...:|......|:.:||:|....:.|:
Human   120 NFIKVFVPR--NDEMVFVCGTNAFNPM-----CRYYRLSTLEYDGEEISGLARCPFDARQTNVAL 177

  Fly   250 YVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSF 314
            :.:.       .||:.|.|:|..:|:||:||        ..:.:..||:|||||.:.:|:|:.:.
Human   178 FADG-------KLYSATVADFLASDAVIYRS--------MGDGSALRTIKYDSKWIKEPHFLHAI 227

  Fly   315 EIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGG-KYMISQNWATYLKARMNCSISSEFPF 378
            |.|.:|||||||.|||:.|.||||||||||:||||.|| :.::.::|.::||||:|||:..:..|
Human   228 EYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFF 292

  Fly   379 YFNEIQSVYK------MPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSA 437
            ||:.:||:..      :||    ....|||..|.:.|||||::.:.||...|.|:||||.|.:|.
Human   293 YFDVLQSITDIIQINGIPT----VVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSV 353

  Fly   438 WLPVLNSKVPEPRPGTC--------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDV- 493
            |..|...|||:||||.|        :..:...||..|:||:.|||||.||......|.|.|..| 
Human   354 WTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVR 418

  Fly   494 -ILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIV-QFMHYGQRHSNLVDIFEASPHSEPIREM 556
             .||.:.||  ......|.:.|.||.:.:|.:.|:: :...:....|.|::..||..|::...|.
Human   419 YRLTAISVD--HSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAEN 481

  Fly   557 TLSHKTGSLYVATDHQVKQIDIAMC--------ARRYDSCFR-CVS--DPYCGWDKDVNACRPYQ 610
            ....|..||.:..||....:..:.|        ..||.||.: |::  |||||| ....:|....
Human   482 EEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGW-LSQGSCGRVT 545

  Fly   611 LGLLQDVANETSGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRY 675
            .|:|                                      :|.:....:::||.|  .||.  
Human   546 PGML--------------------------------------LLTEDFFAFHNHSAE--GYEQ-- 568

  Fly   676 TPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRCSPPSQKQDYQKIYSHWCN 740
                  ||..|....|.                         |.|...|.|...|| ||:....:
Human   569 ------DTEFGNTAHLG-------------------------DCHEILPTSTTPDY-KIFGGPTS 601

  Fly   741 EFEKYKSA--------------MKQWQAK---------QEQCGLKDKTGPISSNGKHVN-DVFSN 781
            :.|...|:              :..|:.|         |:.....|.|.|:|...|.|. :|.|.
Human   602 DMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSG 666

  Fly   782 DALVXPRKYLYSFEFLSSATEGVASAHRKLYIFVFVLTIFARF 824
            :                        :::.:::.|.:..:||.|
Human   667 E------------------------SNQMVHMNVLITCVFAAF 685

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema2bNP_001261024.1 Sema_2A 120..579 CDD:200499 165/477 (35%)
Ig 632..720 CDD:299845 11/87 (13%)
SEMA6DNP_001345281.1 Sema_6D 49..513 CDD:200530 169/505 (33%)
PSI 514..>543 CDD:307546 12/29 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..788
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..838
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 852..887
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1018
Herpes_BLLF1 944..>1080 CDD:330317
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1086
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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