DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema2b and SEMA4A

DIOPT Version :9

Sequence 1:NP_001261024.1 Gene:Sema2b / 246538 FlyBaseID:FBgn0264273 Length:824 Species:Drosophila melanogaster
Sequence 2:NP_001180229.1 Gene:SEMA4A / 64218 HGNCID:10729 Length:761 Species:Homo sapiens


Alignment Length:632 Identity:192/632 - (30%)
Similarity:287/632 - (45%) Gaps:98/632 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 HKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSD--IL 170
            |::.:|||.       |..:....|.|||||.:.|..|::::  ..:.....:|..| .||  ..
Human    57 HQKGLQDFD-------TLLLSGDGNTLYVGAREAILALDIQD--PGVPRLKNMIPWP-ASDRKKS 111

  Fly   171 NCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTH-LPRSQYVPGIGLG 234
            .|..|.|..:.:|.|.|||:  :::|...||.|||.|.:|....|....:: ||.|:  ..:..|
Human   112 ECAFKKKSNETQCFNFIRVL--VSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISE--DKVMEG 172

  Fly   235 IGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGR----KEANFK 295
            .|:.|:|||...|||.|:.       .||:||...|..::.::.|      |.|.    |..||.
Human   173 KGQSPFDPAHKHTAVLVDG-------MLYSGTMNNFLGSEPILMR------TLGSQPVLKTDNFL 224

  Fly   296 RTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNW 360
            |.:.:|:      :||.:....:.|||||.|.|.|:....:...||||||||||.||:.::.:.|
Human   225 RWLHHDA------SFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKW 283

  Fly   361 ATYLKARMNCSISSEFPFYFNEIQSVYKMPTDD---TKFYATFTT--NTNGLIGSAVCSYDIRDI 420
            .|:|||::.|:...:.|  ||.|:....:|.|.   ...||.||:  ...|...||||::.:.||
Human   284 TTFLKAQLLCTQPGQLP--FNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDI 346

  Fly   421 NAAFDGKFKEQATSNSAWLPVLNSKVPE--PRPGTCHNDTATLPDSVLNFIRKHPLMDKAVDHEF 483
            ...|.||:||.....|.|   ...:.||  ||||:|  ......|..|.|::.|.|||:.|   .
Human   347 ERVFKGKYKELNKETSRW---TTYRGPETNPRPGSC--SVGPSSDKALTFMKDHFLMDEQV---V 403

  Fly   484 GNPVFFKRDVILTKLVVDKIR-IDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEAS 547
            |.|:..|..|..|:|.|:..: :|  ....||.::.||:|.::|.|.   .|...::||:..:..
Human   404 GTPLLVKSGVEYTRLAVETAQGLD--GHSHLVMYLGTTTGSLHKAVV---SGDSSAHLVEEIQLF 463

  Fly   548 PHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCV--SDPYCGWDKDVNAC---- 606
            |..||:|.:.|:...|:::|.....|.::..|.|: .|:||..||  .||:|.||.:...|    
Human   464 PDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCS-VYESCVDCVLARDPHCAWDPESRTCCLLS 527

  Fly   607 RPYQLGLLQDVANE------TSGICDTSV-------LRKKVTSSYGQTLHLSCFVKMPEVLRKKQ 658
            .|......||:...      .||....|:       :.|:|.:.....|.|.|    |.:.....
Human   528 APNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPC----PHLSALAS 588

  Fly   659 TRWYHHSTEKGRYEV-RYTPTKYIDTNEGGLVLLAVNEGDGGRYDSY 704
            ..|.|     |...| ..:.|.|     .|.:||.|.:|.||.|..:
Human   589 YYWSH-----GPAAVPEASSTVY-----NGSLLLIVQDGVGGLYQCW 625

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema2bNP_001261024.1 Sema_2A 120..579 CDD:200499 149/473 (32%)
Ig 632..720 CDD:299845 20/74 (27%)
SEMA4ANP_001180229.1 Sema_4A 55..495 CDD:200517 153/485 (32%)
PSI 496..541 CDD:214655 15/45 (33%)
Ig 566..638 CDD:353325 20/74 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 722..749
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.870

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