Protein Alignment Sema2b and SEMA3F

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_004177.3
• Gene: SEMA3F / 6405
• HGNCID: 10728
• Length: 785
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 209/671 - (31%)
• Similarity: 304/671 - (45%)
• Gaps: 120/671 - (17%)

  Fly   111 HVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSD--ILNCV 173
            |..:|......|:....||.::.:|||:.|.:..|:|.:|:     |:.||:....|.  |..||
Human    46 HFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDIN-----REPLIIHWAASPQRIEECV 105

  Fly   174 SKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVIN----ANLTHLPRSQYVPGIG-- 232
            ..||....||.|.:|:|||  :|...||||||.|:||....:|    |..|...::|.|.|.|
Human   106 LSGKDVNGECGNFVRLIQP--WNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSR 168

  Fly   233 ---------------------------LGIGKCPYDP-ADNSTAVYVENGNPFGLPALYAGTNAE 269
                                       .|.||||||| .|.::|:..|.        ||||...:
Human   169 ATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEE--------LYAGVYID 225

  Fly   270 FTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEI-------GEFVYFFFREH 327
            |...|:.|||      |.|::.|  .||.:|:|:.|:.|:|:.:..|       .:.:||||||.
Human   226 FMGTDAAIFR------TLGKQTA--MRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFRER 282

  Fly   328 AVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSE--FPFYFNEIQSVYKMP 390
            :.|... ..|||:|:.|:|.||.||...:...|:|:||||:.||:..|  ...:|:|:|.|:...
Human   283 SAEAPQ-SPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQ 346

  Fly   391 TDDTK---FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPG 452
            |.|.:   .||.||::.:...|||||.|.:.||...|:|.|..:...|..|:| .:.|:|.||||
Human   347 TQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMP-FSGKMPYPRPG 410

  Fly   453 TCHNDTAT--------LPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDV--ILTKLVVDKIRIDK 507
            ||...|.|        .||.|:||:|.||||.:||......|:..:...  .||.:.||  ::|.
Human   411 TCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVD--QVDA 473

  Fly   508 LNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNL----VDIFEASPHSEPIREMTLSHKTGSLYVA 568
            .:..:.|.|:.|..|.:.|::......|....|    |::|:   ...|::.||:|.|...||||
Human   474 ADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFK---DPAPVKTMTISSKRQQLYVA 535

  Fly   569 TDHQVKQIDIAMCARRYDSCFRC--VSDPYCGWDKDVNACRPY-----QLGLLQDVAN-----ET 621
            :...|..:.:..|.....:|..|  ..||||.||.  .||..|     :....|||.:     :.
Human   536 SAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDG--QACSRYTASSKRRSRRQDVRHGNPIRQC 598

  Fly   622 SGICDTSVLRKKVTSSY-----GQTLHLSCFVKMPEVLRKKQTRW-YHHSTEKGRYEVRYTPTKY 680
            .|.  .|...|....|.     |....|.|..:.|:.    ..:| :.......|.|:| ...::
Human   599 RGF--NSNANKNAVESVQYGVAGSAAFLECQPRSPQA----TVKWLFQRDPGDRRREIR-AEDRF 656

  Fly   681 IDTNEGGLVLLAVNEGDGGRY 701
            :.| |.||:|.|:...|.|.|
Human   657 LRT-EQGLLLRALQLSDRGLY 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	171/520 (33%)
		PSI	583..>606	CDD:396154	8/24 (33%)
		Ig	632..724	CDD:472250	19/76 (25%)
		Ig strand B	642..646	CDD:409353	1/3 (33%)
		Ig strand C	658..662	CDD:409353	1/4 (25%)
		Ig strand E	686..690	CDD:409353	2/3 (67%)
		Ig strand F	700..705	CDD:409353	1/2 (50%)
		Ig strand G	717..720	CDD:409353
SEMA3F	NP_004177.3	Sema_3F	48..548	CDD:200515	172/529 (33%)
		PSI	547..584	CDD:214655	12/38 (32%)
		Ig_Sema3	608..697	CDD:409455	18/75 (24%)
		Ig strand A	608..614	CDD:409455	1/5 (20%)
		Ig strand B	619..627	CDD:409455	2/7 (29%)
		Ig strand C	633..639	CDD:409455	1/9 (11%)
		Ig strand C'	641..644	CDD:409455	0/2 (0%)
		Ig strand D	654..658	CDD:409455	0/3 (0%)
		Ig strand E	661..668	CDD:409455	3/6 (50%)
		Ig strand F	674..683	CDD:409455	2/3 (67%)
		Ig strand G	686..697	CDD:409455
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	752..785