DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and sema3c

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_002933132.1	Gene:	sema3c / 613059	XenbaseID:	XB-GENE-1014800	Length:	748	Species:	Xenopus tropicalis

Alignment Length:	768	Identity:	219/768 - (28%)
Similarity:	327/768 - (42%)	Gaps:	155/768 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 CCTGSSAA------HHLRHHK-EHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQ 152
            |.||:..|      |.|:..| ......|..||.|:...|||..:.:|||:.|.|..||:.|||.
Frog    18 CVTGTLQARIFLTLHELQETKTSEFYSISQSPLDYRILLMDEDQDRIYVGSKDHILSLNINNISH 82

  Fly   153 SICERDVLILEPTG-SDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVIN 216
            .    .:.:..|.. |.:..|...||.....|.|.:||||  |||...|||||:.|.:|....||
Frog    83 D----PLSVFWPASTSKVEECKMAGKDPTHGCGNFVRVIQ--NFNRTHLYVCGSGAFSPVCTYIN 141

  Fly   217 ANLTHLPRSQ-YVPGIGL----GIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSV 276
            ..    .||: ::..|..    |.|:|.::|..|:.:|.:..       .|::|...:|...||.
Frog   142 RG----RRSEDHIFAIDYKNESGKGRCSFNPKVNTVSVMINE-------ELFSGMYIDFMGTDSA 195

  Fly   277 IFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFV-------GSFEIGEFVYFFFREHAVEYINC 334
            ||||    ||    :.|..||.:::||.|.:|.||       |:......||||.:|...:....
Frog   196 IFRS----LT----KRNAVRTDQHNSKWLSEPIFVDAQLLPDGTDPNDAKVYFFLKERLTDNSGS 252

  Fly   335 GKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSE--FPFYFNEIQSVYKMPTDD---T 394
            .|.::|.:||||.||.||:..:...|.|:||||:.||:..:  ...||:|::.|:.|.||:   |
Frog   253 TKQIHSMIARVCPNDIGGQRSLVNKWTTFLKARLVCSVMDDDGTETYFDELEDVFLMETDNPRTT 317

  Fly   395 KFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTC----- 454
            ..|..|||:::...|||||.|.:.||...|:|.|..:...|...:| ...::|.||||||
Frog   318 LVYGIFTTSSSVFKGSAVCVYHMSDIQTVFNGPFAHKEGPNHQLIP-YQGRIPYPRPGTCPGGAF 381

  Fly   455 ---HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFK--RDVILTKLVVDKIRIDKLNQEFLV 514
               ...|...||.|:.|||.||||..::......|:..:  .|...||:|||  |::..:.::.|
Frog   382 TPNMKSTKEFPDDVVTFIRNHPLMFNSIYPTLKRPLLIRTGTDYKFTKIVVD--RVNAADGKYHV 444

  Fly   515 YFVATTSGHIYKIVQFMHYGQRHSNLV----DIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQ 575
            .|:.|..|.:.|:|.....|.....|:    ::|::  |: ||..|.:|.|...|||:::..:.|
Frog   445 LFLGTDKGTVQKVVVVPANGSASGELILEEMEVFKS--HA-PITSMKISSKKQQLYVSSEEGITQ 506

  Fly   576 IDIAMCARRYDSCFRC--VSDPYCGWD-----------------------KDVNACRPYQLGLLQ 615
            :.:..|.....:|..|  ..||||.||                       ..|..||.:.|
Frog   507 LSLHRCHIYGTACADCCLARDPYCAWDGKFCSRFYPSGKRRSRRQDVKHGNPVTQCRGFNL---- 567

  Fly   616 DVANETSGICDTSVLRKKVTSSYG---QTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTP 677
                  .|..:|:.:     ..||   .|..|.|..|.|:.    ..:|........|.||:..
Frog   568 ------KGYRNTAEI-----VQYGVRNNTTFLECIAKSPQA----SVKWLLQKDNDRRKEVKLN- 616

  Fly   678 TKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRC--SPPSQKQDYQKIYSHWCN 740
            .:.|.|.: ||::.:|.|.|.|.|                   .|  :..:.||...|:     |
Frog   617 ERIIATGQ-GLLIRSVQEVDQGLY-------------------HCIATENTFKQTIAKV-----N 656

  Fly   741 ------EFEKYKSAMKQWQAKQEQCGL----KDKTGPISSNGKHVNDVFSNDA 783
                  |...:.:...||.......|:    ||.||..|.:...:.:.:..::
Frog   657 LKVLEPELVTFMTDKSQWLWASTLSGMQFHPKDLTGAFSHSEMQIINQYCKES 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	161/490 (33%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	20/90 (22%)
sema3c	XP_002933132.1	Sema_3C	43..512	CDD:200512	163/499 (33%)
		PSI	511..548	CDD:214655	9/36 (25%)
		Ig_Semaphorin_classIII	573..662	CDD:143279	26/123 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100