Protein Alignment Sema2b and SEMA4G

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_060363.2
• Gene: SEMA4G / 57715
• HGNCID: 10735
• Length: 843
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 199/682 - (29%)
• Similarity: 286/682 - (41%)
• Gaps: 143/682 - (20%)

  Fly   106 RHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDIL 170
            ||.|...|       :|.|..::|.:..|.|||...:|.|:..:|.....:.  :..|.:.....
Human    47 RHFKGQAQ-------NYSTLLLEEASARLLVGARGALFSLSANDIGDGAHKE--IHWEASPEMQS 102

  Fly   171 NCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGI 235
            .|..|||..:.||.||:|.:|  ..|...||.|||:|..|....|:|....||.|     ...|.
Human   103 KCHQKGKNNQTECFNHVRFLQ--RLNSTHLYACGTHAFQPLCAAIDAEAFTLPTS-----FEEGK 160

  Fly   236 GKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKY 300
            .|||||||...|.:.::.|       ||..|..||..... |.||         :..:..||.:.
Human   161 EKCPYDPARGFTGLIIDGG-------LYTATRYEFRSIPD-IRRS---------RHPHSLRTEET 208

  Fly   301 DSKLLDKPNFVGSFEIGEF----------VYFFFREHAVEYINCGKAVY---------SRVARVC 346
            ....|:...||.|..:.|.          ||:||.|.|.|.   |...:         :||||||
Human   209 PMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEE---GSGSFTQSRSSHRVARVARVC 270

  Fly   347 KNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTDD---TKFYATFTTNT--NG 406
            |.|.|||.::.:.|.::||||:.|.|    |.| ..::.|..:..:.   |.|||.||.:|  ..
Human   271 KGDLGGKKILQKKWTSFLKARLICHI----PLY-ETLRGVCSLDAETSSRTHFYAAFTLSTQWKT 330

  Fly   407 LIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTC---------HNDTATLP 462
            |..||:|.||:.:|.|.|.|.:.|....:..| ......|||||||:|         :|.:..||
Human   331 LEASAICRYDLAEIQAVFAGPYMEYQDGSRRW-GRYEGGVPEPRPGSCITDSLRSQGYNSSQDLP 394

  Fly   463 DSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKI 527
            ..||:|::.||||.:.|....|.|:..||::..|.|....: .......:.:.|:.|..|.|:|.
Human   395 SLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPV-TTPAGPTYDLLFLGTADGWIHKA 458

  Fly   528 VQF---MHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCF 589
            |..   ||       :::..:....|:.:..:.:|....||||.....|.|:.::.|: ||.||:
Human   459 VVLGSGMH-------IIEETQVFRESQSVENLVISLLQHSLYVGAPSGVIQLPLSSCS-RYRSCY 515

  Fly   590 RCV--SDPYCGWDKDVNAC----------RPYQLGLLQDVANETSGICDT-------------SV 629
            .|:  .|||||||...:||          :..:..|:||:.....| |::             ||
Human   516 DCILARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDIERGNRG-CESSRDTGPPPPLKTRSV 579

  Fly   630 LRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHH-----STEKGRYEVRYTPTKYIDTNEGGLV 689
            ||       |..:.|.|  ..|..|.:  ..|..:     |..:|.|.|.      :|    ||:
Human   580 LR-------GDDVLLPC--DQPSNLAR--ALWLLNGSMGLSDGQGGYRVG------VD----GLL 623

  Fly   690 LLAVNEGDGGRYDSYLD----GTLLCSYGVTV 717
            :........|.|..|.:    .|||.||.:||
Human   624 VTDAQPEHSGNYGCYAEENGLRTLLASYSLTV 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	148/494 (30%)
		PSI	583..>606	CDD:396154	12/24 (50%)
		Ig	632..724	CDD:472250	23/95 (24%)
		Ig strand B	642..646	CDD:409353	1/3 (33%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353	2/3 (67%)
		Ig strand F	700..705	CDD:409353	1/4 (25%)
		Ig strand G	717..720	CDD:409353	1/1 (100%)
SEMA4G	NP_060363.2	Sema_4G	47..506	CDD:200523	152/508 (30%)
		PSI	507..>534	CDD:396154	13/27 (48%)
		Ig_Sema4B_like	572..655	CDD:409456	25/103 (24%)
		Ig strand A	572..578	CDD:409456	0/5 (0%)
		Ig strand B	582..590	CDD:409456	3/9 (33%)
		Ig strand C	596..602	CDD:409456	1/7 (14%)
		Ig strand C'	604..607	CDD:409456	0/2 (0%)
		Ig strand D	614..618	CDD:409456	1/3 (33%)
		Ig strand E	620..627	CDD:409456	3/10 (30%)
		Ig strand F	633..642	CDD:409456	3/8 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	728..782