Protein Alignment Sema2b and sema4ga

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: XP_073776800.1
• Gene: sema4ga / 563785
• ZFINID: ZDB-GENE-060503-381
• Length: 863
• Species: Danio rerio
• Alignment Length: 842
• Identity: 220/842 - (26%)
• Similarity: 353/842 - (41%)
• Gaps: 203/842 - (24%)

  Fly    57 HRLCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHHKEHVQDFSCGP-- 119
            ||...|..|||.:|:             :.|...::||.                  |....|
Zfish     7 HRAWLLFLLLLYVVS-------------SVWGYPFKPPL------------------DLDVTPRT 40

  Fly   120 -----------------LHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGS 167
                             |:|....::|..:.|||||...:|.|...::|.|:.:  .:..|.:..
Zfish    41 TVLFKGLLGCRRFRGLTLNYSLLLLEEDADLLYVGARGALFALQASDVSSSLAQ--TIDWEASDD 103

  Fly   168 DILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNP-------KDYVINANLTHLPRS 225
            .:..|.:|||..:.||.||||.:|  .||...||.|||:|.:|       :::.|::....
Zfish   104 QMQQCWNKGKDNQTECFNHIRFLQ--RFNSTHLYTCGTHAFSPLCAYIDGREFKISSVFEE---- 162

  Fly   226 QYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRK 290
                    |..||||||:...|.:.::.       .:|..:..||.....:           .|.
Zfish   163 --------GREKCPYDPSKGYTGLLIDQ-------QMYTASQYEFRSFPDI-----------RRN 201

  Fly   291 EAN-FKRTVKYDSKLLDKPNFVGSFEIGEF----------VYFFFREHAVE---YINCGKAVYSR 341
            ..| ..:|.:..::.|.:.:||||..:.|.          :||||.|.:.|   |.:..:.  :|
Zfish   202 SPNPILKTEEAPTQWLQEADFVGSALVRESLSSSAGDDDKIYFFFTEKSQELSPYFSHSRV--AR 264

  Fly   342 VARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKM---PTDDTKFYATFTTN 403
            ||||||.||||...:.:.|.::||||:.||: .::.|:||.::||:.:   .:.|:.||..|...
Zfish   265 VARVCKRDRGGLLTLQKKWTSFLKARLVCSL-PDYEFHFNVLRSVFFLEGSSSQDSAFYGIFGLE 328

  Fly   404 TNGLIGSAVCSYDIRDINAAFDGKFKE-QATSNSAWLPVLNSKVPEPRPGTC----H-----NDT 458
            ...:..||:|.|.:.||..||||.:.| :..|||.|.. ...||||||||:|    |     |.:
Zfish   329 WKNVKASAICQYSVSDIQWAFDGPYMESKEDSNSKWTQ-YTGKVPEPRPGSCITDQHRAKGINSS 392

  Fly   459 ATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIR-IDKLNQEFLVYFVATTSG 522
            ..|||.||:|:|:||||.:.:..:...|:.|:|:|..||:.|..:. :|  .|.:.:.|:.|..|
Zfish   393 INLPDDVLHFVRRHPLMYRQILPQGQRPLLFRRNVDYTKIAVHTVTGLD--GQIYHILFIGTDEG 455

  Fly   523 HIYKIVQFMHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDS 587
            .:.:.|:.    :.|.::::..:.....:|:..:.:|.|..|:||.:...|.|:.::.|. ||.|
Zfish   456 WLQRAVKV----EDHLHIIEELQLFEEPQPVDSIVISKKQMSVYVGSPTSVVQLPLSTCT-RYSS 515

  Fly   588 CFRCV--SDPYCGWD----KDVNACRPYQLGLLQDVANETSGICDTS-----VLRKKVTSSYGQT 641
            ||.||  .||:|.||    .|:.: ...:..|.||:.|...| ||.|     ||.:..:...|..
Zfish   516 CFDCVMARDPFCAWDGLECVDITS-HNSRANLTQDIQNGNQG-CDKSTADDQVLHRSRSVMAGDD 578

  Fly   642 LHLSCFVK----MPEVLRKKQTRWYHHSTE-KGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRY 701
            :.|.|.:.    .||        |..:..| ||     |...........||:::.......|.|
Zfish   579 VLLQCELSSNLATPE--------WTLNGNELKG-----YGLDSGFRVGTDGLLVIEAQPYQSGDY 630

  Fly   702 DSY-LDGTL---LCSYGVTVDAHRCSPPSQKQDYQKIYSHWCNEFEKYKSAMKQWQAKQEQCGLK 762
            ..: ::.::   :..|.:||......||..|....:..:      |.|      |.::..|...:
Zfish   631 CCFAIENSVRVPVLIYSLTVRQELPVPPPVKPTQPRFTT------EIY------WTSQSSQSDSE 683

  Fly   763 DKTGPISSNGKHVNDVFSNDALVXPRKYLYSFEFLSSATEGVASAHRKLYIFV----FVLTI 820
            :...|..               :.||     |||||  ...:.:.:..|...:    ||||:
Zfish   684 EDFDPTP---------------MSPR-----FEFLS--VRNMEAMYLSLITILGGLCFVLTV 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	147/493 (30%)
		PSI	583..>606	CDD:396154	13/28 (46%)
		Ig	632..724	CDD:472250	17/100 (17%)
		Ig strand B	642..646	CDD:409353	1/3 (33%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353	2/3 (67%)
		Ig strand F	700..705	CDD:409353	1/5 (20%)
		Ig strand G	717..720	CDD:409353	1/2 (50%)
sema4ga	XP_073776800.1	None