DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and sema5ba

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_684379.3	Gene:	sema5ba / 556471	ZFINID:	ZDB-GENE-070912-187	Length:	1101	Species:	Danio rerio

Alignment Length:	743	Identity:	231/743 - (31%)
Similarity:	345/743 - (46%)	Gaps:	126/743 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 LYYEPPCCTGSS---AAHHLR---HHKEH-----------VQDFS-CGPLHYKTFYMDERNNALY 135
            |...||..|.:|   |.||.|   ...||           :..|| .|...|....:|...|.|.
Zfish    29 LSQNPPVPTETSPSPAPHHTRPECTRLEHPVVSIQALSPLISSFSHPGVRDYSQLTLDLTRNELI 93

  Fly   136 VGAMDRIFRLNLRNISQSICERDVLILEPT--GSD---ILNCVSKGKREKVECRNHIRVIQPMNF 195
            |||.:.:|||||.|||         :::.|  |.|   ..:|.||||.| :||:|:|||:.   .
Zfish    94 VGARNYLFRLNLSNIS---------LIQATEWGPDEDTRRSCQSKGKTE-LECQNYIRVLL---V 145

  Fly   196 NGQKLYVCGTNAHNPKDYVINA-NLTH-LPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFG 258
            |..::..|||||..|......| |::. |.|..       |:.:|||||..|||||..|:|.
Zfish   146 NKTEVVTCGTNAFQPLCITREAGNMSRVLERVN-------GVARCPYDPRHNSTAVVTESGE--- 200

  Fly   259 LPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFVYFF 323
               |||.|..:|:..|.||:||     ..|....   ||.:|:||.|::|:|:.::::|.|.:||
Zfish   201 ---LYAATVIDFSGRDPVIYRS-----LGGMPPL---RTAQYNSKWLNEPHFISAYDVGLFTFFF 254

  Fly   324 FREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYK 388
            .||:|||: :|||.||||||||||||.||::::...|.|:.|||:|||.|.|.|||:||:||.:.
Zfish   255 LRENAVEH-DCGKTVYSRVARVCKNDIGGRFLLEDTWTTFTKARLNCSRSGEIPFYYNELQSTFY 318

  Fly   389 MPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGT 453
            :|..|. .|..||||.|.:..||||:|::..|..||:|.|:.|....|.|||..| .:|..:.||
Zfish   319 LPEQDL-IYGIFTTNVNSIAASAVCAYNLSAITQAFNGPFRSQENPRSTWLPTPN-PIPNFQCGT 381

  Fly   454 CHND--TATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFL--V 514
            ...:  ...|.:..|...::..||:..|.....:|:.::.||..:|||||.::    .|:.|  |
Zfish   382 IDEEGPNERLTERSLQDAQRLFLMNDVVQPVSVDPLVWQDDVRFSKLVVDIVQ----GQDSLHHV 442

  Fly   515 YFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPH-SEPIREMTLSHKTGSLYVATDHQVKQIDI 578
            .::.|..|.|.|.:...:...:...|.::....|. .:||..:.:.|...:|:|..:.:|.:|.:
Zfish   443 MYIGTEYGTILKALATTNKSLQGCYLEEMQLFPPGLQQPILSLQILHGDRTLFVGLNDKVLKIPL 507

  Fly   579 AMCARRYDSCFRCVS--DPYCGWDKDVNACRPYQLGLLQDVANETSGICDTSV--LRKKVT-SSY 638
            |.|: .|.:...|:.  |||||||:....|.     .::|.:|.:....:.:.  ||.:.| .:|
Zfish   508 ARCS-SYKTELMCLDARDPYCGWDRKQRRCT-----TIEDSSNMSQWFQNITACPLRNQTTDGAY 566

  Fly   639 GQTLHLSCFVKMPEVLRKKQTRWYHHSTEKG--------RYEVRYTPTKYIDTN--EGGLVLLAV 693
            |                 ....|...|.:.|        |..|..:|.......  :|..:.::.
Zfish   567 G-----------------PWAPWQPCSHDDGEGTSTCLCRSRVCNSPPPRCGGKNCQGPTIEVSN 614

  Fly   694 NEGDGG--RYDSYLDGTLLCSYGVTVDAHRCSPPSQKQD-----YQKIYSHWCNEFEK-----YK 746
            ...:||  .:.|:...:..|..|..|....|:.||.:..     .|.....:|||...     :.
Zfish   615 CSRNGGWTPWSSWGQCSTSCEIGFEVRQRSCNNPSPRHGGRVCVGQSREQRFCNEKVSCPQPIFW 679

  Fly   747 SAMKQWQAKQEQCGLKDKTGPISSNGKH 774
            |:...|......||     |.:.|..::
Zfish   680 SSWSPWSKCSADCG-----GGVHSRSRN 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	172/470 (37%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	16/100 (16%)
sema5ba	XP_684379.3	Sema	72..508	CDD:301699	175/476 (37%)
		PSI	509..556	CDD:279745	13/52 (25%)
		TSP1	567..618	CDD:214559	8/67 (12%)
		TSP1	621..674	CDD:214559	11/52 (21%)
		TSP1	679..725	CDD:214559	6/29 (21%)
		TSP1	808..860	CDD:214559
		TSP1	871..917	CDD:214559
		TSP1	920..960	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810