Protein Alignment Sema2b and sema5ba

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: XP_684379.3
• Gene: sema5ba / 556471
• ZFINID: ZDB-GENE-070912-187
• Length: 1101
• Species: Danio rerio
• Alignment Length: 743
• Identity: 231/743 - (31%)
• Similarity: 345/743 - (46%)
• Gaps: 126/743 - (16%)

  Fly    89 LYYEPPCCTGSS---AAHHLR---HHKEH-----------VQDFS-CGPLHYKTFYMDERNNALY 135
            |...||..|.:|   |.||.|   ...||           :..|| .|...|....:|...|.|.
Zfish    29 LSQNPPVPTETSPSPAPHHTRPECTRLEHPVVSIQALSPLISSFSHPGVRDYSQLTLDLTRNELI 93

  Fly   136 VGAMDRIFRLNLRNISQSICERDVLILEPT--GSD---ILNCVSKGKREKVECRNHIRVIQPMNF 195
            |||.:.:|||||.|||         :::.|  |.|   ..:|.||||.| :||:|:|||:.   .
Zfish    94 VGARNYLFRLNLSNIS---------LIQATEWGPDEDTRRSCQSKGKTE-LECQNYIRVLL---V 145

  Fly   196 NGQKLYVCGTNAHNPKDYVINA-NLTH-LPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFG 258
            |..::..|||||..|......| |::. |.|..       |:.:|||||..|||||..|:|.
Zfish   146 NKTEVVTCGTNAFQPLCITREAGNMSRVLERVN-------GVARCPYDPRHNSTAVVTESGE--- 200

  Fly   259 LPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFVYFF 323
               |||.|..:|:..|.||:||     ..|....   ||.:|:||.|::|:|:.::::|.|.:||
Zfish   201 ---LYAATVIDFSGRDPVIYRS-----LGGMPPL---RTAQYNSKWLNEPHFISAYDVGLFTFFF 254

  Fly   324 FREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYK 388
            .||:|||: :|||.||||||||||||.||::::...|.|:.|||:|||.|.|.|||:||:||.:.
Zfish   255 LRENAVEH-DCGKTVYSRVARVCKNDIGGRFLLEDTWTTFTKARLNCSRSGEIPFYYNELQSTFY 318

  Fly   389 MPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGT 453
            :|..|. .|..||||.|.:..||||:|::..|..||:|.|:.|....|.|||..| .:|..:.||
Zfish   319 LPEQDL-IYGIFTTNVNSIAASAVCAYNLSAITQAFNGPFRSQENPRSTWLPTPN-PIPNFQCGT 381

  Fly   454 CHND--TATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFL--V 514
            ...:  ...|.:..|...::..||:..|.....:|:.::.||..:|||||.::    .|:.|  |
Zfish   382 IDEEGPNERLTERSLQDAQRLFLMNDVVQPVSVDPLVWQDDVRFSKLVVDIVQ----GQDSLHHV 442

  Fly   515 YFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPH-SEPIREMTLSHKTGSLYVATDHQVKQIDI 578
            .::.|..|.|.|.:...:...:...|.::....|. .:||..:.:.|...:|:|..:.:|.:|.:
Zfish   443 MYIGTEYGTILKALATTNKSLQGCYLEEMQLFPPGLQQPILSLQILHGDRTLFVGLNDKVLKIPL 507

  Fly   579 AMCARRYDSCFRCVS--DPYCGWDKDVNACRPYQLGLLQDVANETSGICDTSV--LRKKVT-SSY 638
            |.|: .|.:...|:.  |||||||:....|.     .::|.:|.:....:.:.  ||.:.| .:|
Zfish   508 ARCS-SYKTELMCLDARDPYCGWDRKQRRCT-----TIEDSSNMSQWFQNITACPLRNQTTDGAY 566

  Fly   639 GQTLHLSCFVKMPEVLRKKQTRWYHHSTEKG--------RYEVRYTPTKYIDTN--EGGLVLLAV 693
            |                 ....|...|.:.|        |..|..:|.......  :|..:.::.
Zfish   567 G-----------------PWAPWQPCSHDDGEGTSTCLCRSRVCNSPPPRCGGKNCQGPTIEVSN 614

  Fly   694 NEGDGG--RYDSYLDGTLLCSYGVTVDAHRCSPPSQKQD-----YQKIYSHWCNEFEK-----YK 746
            ...:||  .:.|:...:..|..|..|....|:.||.:..     .|.....:|||...     :.
Zfish   615 CSRNGGWTPWSSWGQCSTSCEIGFEVRQRSCNNPSPRHGGRVCVGQSREQRFCNEKVSCPQPIFW 679

  Fly   747 SAMKQWQAKQEQCGLKDKTGPISSNGKH 774
            |:...|......||     |.:.|..::
Zfish   680 SSWSPWSKCSADCG-----GGVHSRSRN 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	172/470 (37%)
		PSI	583..>606	CDD:396154	9/24 (38%)
		Ig	632..724	CDD:472250	17/104 (16%)
		Ig strand B	642..646	CDD:409353	0/3 (0%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353	1/3 (33%)
		Ig strand F	700..705	CDD:409353	1/4 (25%)
		Ig strand G	717..720	CDD:409353	1/2 (50%)
sema5ba	XP_684379.3	Sema	72..508	CDD:472829	175/476 (37%)
		PSI	509..556	CDD:396154	13/52 (25%)
		TSP1	567..618	CDD:214559	8/67 (12%)
		TSP1	621..674	CDD:214559	11/52 (21%)
		TSP1	679..725	CDD:214559	6/29 (21%)
		TSP1	808..860	CDD:214559
		TSP1	871..917	CDD:214559
		TSP1	920..960	CDD:214559