DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and sema3c

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_017210807.2	Gene:	sema3c / 553130	ZFINID:	ZDB-GENE-050513-5	Length:	757	Species:	Danio rerio

Alignment Length:	735	Identity:	196/735 - (26%)
Similarity:	309/735 - (42%)	Gaps:	141/735 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 LHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTG-SDILNCVSKGKREKVEC 183
            :.|:..:.||..:.:|||..|.|..:::.||||:..:    |..|.. |.:..|...||.....|
Zfish    62 MDYRILFTDEDQDRMYVGCKDHILSMDINNISQATLK----IFWPASISKVEECQMAGKDPTHGC 122

  Fly   184 RNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYV---PGIGLGIGKCPYDPADN 245
            .|.:|||||  :|...|::||:.|::|....:|..  ..|..|..   .....|.|:|.::|..|
Zfish   123 GNFLRVIQP--YNRTHLFICGSGAYSPVCAYVNRG--RRPEEQVFQISSRAESGKGRCSFNPQVN 183

  Fly   246 STAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNF 310
            :.:|.:..       .|::|...:|...|:.||||    ||.    .|..||.:::||.|.:|.|
Zfish   184 TVSVMLNQ-------ELFSGMYIDFMGTDAAIFRS----LTT----RNPVRTDQHNSKWLSEPLF 233

  Fly   311 V-------GSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARM 368
            :       ||......:|||.||...:.....|.:::.|||||.||.||:..:...|.|:|||||
Zfish   234 IDAQLIPDGSDPNDAKLYFFLRERLTDTSGNTKNIHAMVARVCPNDTGGQRSLVNKWTTFLKARM 298

  Fly   369 NCSISSE--FPFYFNEIQSVYKMPTDDTK---FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKF 428
            .||:..|  ...:|:|:::|:.:.||..|   .:..||:.::...|||||.|::.||...|:|.|
Zfish   299 VCSVLEEDGTETHFDELENVFLLETDHPKGLLIFGVFTSTSSVFRGSAVCVYNMADILTVFNGPF 363

  Fly   429 KEQATSNSAWLPVLNSKVPEPRPGTC-------H-NDTATLPDSVLNFIRKHPLMDKAVDHEFGN 485
            ..:...|..|: ....::|.||||||       | ..|...||.|:.|:|.||:|        .|
Zfish   364 AHREGPNFQWV-AFQGRIPYPRPGTCPGGAFTPHIQSTKEFPDDVVTFVRNHPVM--------FN 419

  Fly   486 PVF----------FKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNL 540
            |::          ...|...|.:.||  ::...:..:.|.|:.|..|.:.|:|.....|....:|
Zfish   420 PIYPVGRKPLVVRTHADYKYTSIAVD--QVPAADGHYQVLFLGTDKGTVQKVVVLPSNGSLDEDL 482

  Fly   541 V----DIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRC--VSDPYCGW 599
            :    ::|:.   ..||..:.:|.|...|||:::|.:.|:.:..|.....:|..|  ..||||.|
Zfish   483 ILEELEVFKT---QSPITNLRISSKKQQLYVSSEHGISQVSLHRCNAYGSACADCCLARDPYCAW 544

  Fly   600 DKDVNACRPYQLG----LLQDVAN-----ETSGICDTSVLRKKV-TSSYG---QTLHLSCFVKMP 651
            | .::..|.|..|    ..||:.:     :..|. :....|..| .:.||   .|..|.|..|.|
Zfish   545 D-GLSCSRFYPTGKRRSRRQDIMHGNPLTQCRGF-NLKAYRNAVEMTQYGVKNNTTFLECQPKSP 607

  Fly   652 EVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRY--------------- 701
            :.    ..:|........|.||:.: .:.:.||. ||::.:|:..|.|.|
Zfish   608 QA----SVKWLIQRDNDRRKEVKLS-DRVVSTNH-GLLIRSVHSSDQGLYYCLATENGFKRTLAK 666

  Fly   702 ----------DSYLDGTLLCSYGVTVDAH------------------RCSPPSQKQDYQKIYSHW 738
                      .|.|.......:|.|.:.|                  .|....|.|..|.|.|..
Zfish   667 IRLQVLSEALVSALSNKQQSPWGWTANLHPKALVSAFSPAETLAMHQYCKERKQMQSLQSIQSPM 731

  Fly   739 CNEFEKYKSAMKQWQAKQEQ 758
            ..:..|.|..:...:::..:
Zfish   732 RGDLGKLKPLLDHRKSRNRR 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	147/496 (30%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	24/116 (21%)
sema3c	XP_017210807.2	Sema_3C	55..524	CDD:200512	147/498 (30%)
		PSI	523..568	CDD:214655	14/45 (31%)
		Ig_Semaphorin_classIII	585..674	CDD:143279	20/94 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010