Protein Alignment Sema2b and SEMA4C

DIOPT Version :9

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: XP_016859882.1
• Gene: SEMA4C / 54910
• HGNCID: 10731
• Length: 875
• Species: Homo sapiens
• Alignment Length: 679
• Identity: 204/679 - (30%)
• Similarity: 304/679 - (44%)
• Gaps: 108/679 - (15%)

  Fly    87 WNLYYEPPCCTGSSAAHHLRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNIS 151
            |||.......:|..|....|..:..:|||       .|..:.|....|||||.:.:|..::..:.
Human    67 WNLVPRKTVSSGELATVVRRFSQTGIQDF-------LTLTLTEPTGLLYVGAREALFAFSMEALE 124

  Fly   152 -QSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVI 215
             |.....:..:.:.|     .|:.|||..:.||.|.||.:||  :|...||||||.|..||...:
Human   125 LQGAISWEAPVEKKT-----ECIQKGKNNQTECFNFIRFLQP--YNASHLYVCGTYAFQPKCTYV 182

  Fly   216 NANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRS 280
            |.....|...::..    |.||||||||.....:.|:.       .||:.|...|...:.:|.|:
Human   183 NMLTFTLEHGEFED----GKGKCPYDPAKGHAGLLVDG-------ELYSATLNNFLGTEPIILRN 236

  Fly   281 DLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSF----EIGEF------VYFFFREHAVEYINCG 335
                     ...:.....:|.:..|::|:||||.    .:|.|      |||||||.|||.....
Human   237 ---------MGPHHSMKTEYLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYA 292

  Fly   336 KAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKMPT---DDTKFY 397
            :.|.:|||||||.|.||...:.:.|.|:||||:.|| :..:..|||::|:::.:..   .:|.|:
Human   293 EQVVARVARVCKGDMGGARTLQRKWTTFLKARLACS-APNWQLYFNQLQAMHTLQDTSWHNTTFF 356

  Fly   398 ATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHND----- 457
            ..|......:..||:|.|.:.:|...|:|.:||.......| ......||.||||:|.|:
Human   357 GVFQAQWGDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKW-DRYTDPVPSPRPGSCINNWHRRH 420

  Fly   458 ----TATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIR-IDKLNQEFLVYFV 517
                :..|||::|||::|||||::.|...:..|:..|:....|.||.|::. :|  ...:.|.|:
Human   421 GYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLD--GATYTVLFI 483

  Fly   518 ATTSGHIYKIVQ---FMHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIA 579
            .|..|.:.|.|.   ::|..:.    :.:|:    .||:|.:.||.....|:..:..|:.|:.:|
Human   484 GTGDGWLLKAVSLGPWVHLIEE----LQLFD----QEPMRSLVLSQSKKLLFAGSRSQLVQLPVA 540

  Fly   580 MCARRYDSCFRCV--SDPYCGWDKDVNACRPYQLG------LLQDV-ANETSGICDTSVLR---- 631
            .| .:|.||..||  .||||.|  .||..|...:|      |:|.| .::|||||:   ||
Human   541 DC-MKYRSCADCVLARDPYCAW--SVNTSRCVAVGGHSGSLLIQHVMTSDTSGICN---LRGSKK 599

  Fly   632 -----KKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYI-DTNEGGLVL 690
                 |.:|...|..|.|.|.:..    .....||    |..||......|..:: |.....||:
Human   600 VRPTPKNITVVAGTDLVLPCHLSS----NLAHARW----TFGGRDLPAEQPGSFLYDARLQALVV 656

  Fly   691 LAVNEGDGGRYDSYLD--GTLLCSYGVTV 717
            :|......|.|..:.:  |..|.:.|..|
Human   657 MAAQPRHAGAYHCFSEEQGARLAAEGYLV 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	147/485 (30%)
		Ig	632..720	CDD:299845	22/89 (25%)
SEMA4C	XP_016859882.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870