DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2b and sema3gb

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_005167089.1	Gene:	sema3gb / 544660	ZFINID:	ZDB-GENE-050513-4	Length:	746	Species:	Danio rerio

Alignment Length:	779	Identity:	205/779 - (26%)
Similarity:	338/779 - (43%)	Gaps:	150/779 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 CTGSSAAHHLRH--HKEHVQ-------DFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNIS 151
            |.|::......|  :||.::       .||.....|:..:||:....||:|:.:.:..|:::|::
Zfish    16 CHGNTRTTPRVHLSYKELLETKTIRPFSFSFNTSDYRILHMDQDQGRLYLGSREYLVSLDMQNVN 80

  Fly   152 QSICERDVLILE--PTGSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYV 214
                 ::.||:.  .|......|...||..:.||.|.:|:|:|  :|...||.|||.|:.|....
Zfish    81 -----KEPLIIHWPATTQRKGECKLTGKGGQGECANFVRLIEP--WNRTHLYTCGTGAYKPICTF 138

  Fly   215 INANLTHLPRSQY----VPG-IGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKAD 274
            ||....   ..:|    ||| :..|.||.||||...:.|..: |||      ||:|.:.:|...|
Zfish   139 INRGWR---AEEYLFRLVPGYVDSGKGKSPYDPRQENAAALI-NGN------LYSGVHVDFMGTD 193

  Fly   275 SVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEI-------GEFVYFFFREHAVEYI 332
            ..|||      |.|.:.|  .||.:|||:.|::|.|:...:|       .:.:||||||.::: .
Zfish   194 PAIFR------TLGDRPA--VRTEQYDSRWLNEPVFIKIQKIPDSAEKNDDKLYFFFREKSLD-A 249

  Fly   333 NCGKA--VYSRVARVCKNDRGGKYMISQNWATYLKARMNCSI--SSEFPFYFNEIQSVYKMPTDD 393
            :.|.|  |.:||.|||.||.||:..:...|.|:||||:.||:  :.....||:|::.|:...|.|
Zfish   250 SGGSAPSVLARVGRVCLNDDGGQRSLVNKWTTFLKARLVCSVIGADGVETYFDELRDVFIQRTHD 314

  Fly   394 TK---FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCH 455
            .:   .||.|:|..:...|||||.|.:.||...|:|.|..:...|..|.| ...|:|.||||||.
Zfish   315 ERNPIVYAVFSTAGSVFKGSAVCVYSMSDIRNVFNGPFSHKHGHNYQWTP-YTGKIPYPRPGTCP 378

  Fly   456 NDTAT--------LPDSVLNFIRKHPLMDKAVDHEFGNPVFFKR--DVILTKLVVDKIRIDKLNQ 510
            ..|.|        ..|..:||:|.||||.:.:......|:..:.  |...|.:.||  .:|.::.
Zfish   379 GGTFTPDLHTTKAFSDEAVNFVRAHPLMYQPIYPIHKRPLVVRTGVDYRFTTIAVD--LVDAVDG 441

  Fly   511 EFLVYFVATTSGHIYKIVQFMHYGQRHSNL----VDIFEASPHSEPIREMTLSHKTGSLYVATDH 571
            .:.|.|:.|..|.:.|::...........|    |::|: :|.:  ::.:.:|.|...|||:::.
Zfish   442 RYEVLFLGTDRGTVQKVIVLPKDISTTEELILEEVEVFK-TPAA--VKTLKISTKRQQLYVSSER 503

  Fly   572 QVKQIDIAMCARRYDSCFRC--VSDPYCGWD-KDVNACRP--YQLGLLQDVAN-----ETSGICD 626
            .:.|:.:..||....:|..|  ..||||.|| :..:|..|  .:....||:.:     :..|...
Zfish   504 GLTQVSLHRCAVYGKACSDCCLARDPYCAWDGEHCSAFTPATKRRSRRQDIKHGDPLRQCRGFNA 568

  Fly   627 TSVLRKKVTSSY---GQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGL 688
            ....|.:.|..:   |.:..|.|..:.|:.    ..:|...  :.||.:......:.:.|.. |:
Zfish   569 KVEKRLRETVQFGVEGSSTFLECQPRSPQA----TVKWLFQ--KDGRRKALSRDKEVLKTGH-GI 626

  Fly   689 VLLAVNEGDGGRY-----DSYLDGTL---------------LCSYGVTVD--------------- 718
            :|.::.:.|.|.|     ::....||               |....:.:|
Zfish   627 LLKSLTQSDAGLYHCLATENNFKHTLARISLRILDREIVEALTESDIPIDPEHRRHHSHQHPPPP 691

  Fly   719 -----AHRCSPPSQKQDYQKIYSHWCNEFEKYKSAMKQWQAKQEQCGLKDKTGPISSNGKHVND 777
                 ||..:.|...|...::.:.:|   :.|:..|:....|.::           :|.:|..:
Zfish   692 PPPPQAHPPALPLHPQPEVRLINQYC---QSYRQQMQSQPQKAKR-----------NNRRHTGE 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	154/493 (31%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	18/130 (14%)
sema3gb	XP_005167089.1	Sema_3F	42..513	CDD:200515	156/502 (31%)
		PSI	512..558	CDD:214655	14/45 (31%)
		Ig_Semaphorin_classIII	576..662	CDD:143279	16/92 (17%)
		IG_like	581..651	CDD:214653	13/76 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910