DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and sema3fa

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_005166096.1	Gene:	sema3fa / 544658	ZFINID:	ZDB-GENE-050513-1	Length:	801	Species:	Danio rerio

Alignment Length:	746	Identity:	227/746 - (30%)
Similarity:	318/746 - (42%)	Gaps:	148/746 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 TGSSAAHHLRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLI 161
            ||:  |||..        |......|:...|||.::.:|||:.|.|..|:|.:|:     ::.||
Zfish    53 TGT--AHHFA--------FLLNSTDYRILRMDEDHDRMYVGSKDYILSLDLNDIN-----KEPLI 102

  Fly   162 LE-PTG-SDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNP-KDYVINANLT--- 220
            :. |.. .....||..||....||.|.||:|:|  :|...||||||.|:|| ..||......
Zfish   103 IHWPVAPQKRTECVLSGKDINGECGNFIRLIEP--WNRTHLYVCGTGAYNPICTYVDRGQRAQGF 165

  Fly   221 ---HLPRS--------------------QYV----PG-IGLGIGKCPYDPADNSTAVYVENGNPF 257
               .:||:                    :|:    || :..|.|||||||..||.:..: ||.
Zfish   166 LQDQMPRAGGRTSRAADPSASPEPYAPKEYIFRLEPGKVDSGKGKCPYDPKLNSVSALI-NGQ-- 227

  Fly   258 GLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEI------ 316
                ||||...:|...||.|||      |.|:..|  .||.:|:|:.|..|.||.:..|
Zfish   228 ----LYAGVYIDFMGTDSAIFR------TLGKHTA--MRTDQYNSRWLHDPTFVHAQLIPDSAEK 280

  Fly   317 -GEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSI--SSEFPF 378
             .:.:||||||.|.|......| .||:.|:|.||.||...:...|:|:||||:.||:  |.....
Zfish   281 NDDKLYFFFREKASEMGQTPMA-QSRIGRICLNDDGGHCCLVNKWSTFLKARLICSVTGSDGIET 344

  Fly   379 YFNEIQSVYKMPTDDTK---FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLP 440
            :|:|::.||...|.|||   .|..|:.:.:...|||||.|.:.|:...|:|.|..:...|..|:
Zfish   345 HFDELRDVYIQKTQDTKNPVIYGVFSVSGSVFKGSAVCVYSMADVRMVFNGPFAHKEGPNYQWV- 408

  Fly   441 VLNSKVPEPRPGTCHNDTAT--------LPDSVLNFIRKHPLMDKAVDHEFGNPVFFKR--DVIL 495
            ....|:|.||||||...|.|        .||.|:||:|.||.|..||......|:..:.  |...
Zfish   409 AYQGKIPYPRPGTCPGGTFTPNMKSTKDYPDEVINFMRTHPTMFNAVYPVHKRPLVVRTNVDYEF 473

  Fly   496 TKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNL----VDIFEASPHSEPIREM 556
            |.:.||::.....|.|  |.|:.|..|.:.|::.......:...|    |::|.. |.|  |..|
Zfish   474 TTITVDQVAAADGNYE--VLFLGTDRGTVQKVIVLPRDDLQTEELVLEEVEVFRV-PTS--ITTM 533

  Fly   557 TLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRC--VSDPYCGWDKDVNACRPY-----QLGLL 614
            .:|.|...|||::...|..:.:..|....::|..|  ..||||.||.  .:|..|     :....
Zfish   534 KISPKRQQLYVSSAVGVTHLALHRCDVYGEACADCCLARDPYCAWDG--KSCSRYSANQKRRSRR 596

  Fly   615 QDV-----ANETSGICDTSVLRKKVTSSY---GQTLHLSCFVKMPEVLRKKQTRWYHHSTEKG-- 669
            |||     ..:..|....:......|..|   |.|..|.|..:.|.|    ..:| |...|..
Zfish   597 QDVKYGNPIRQCRGYNSNANKNTLETVQYGVEGSTAFLECQARSPHV----SIKW-HFQKENSDR 656

  Fly   670 RYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRY-----DSYLDGTLLCSYGVTVDAHR-------- 721
            |.|:| :..:.:.| |.||:|.::...|.|.|     :.....||:....|.:.||.
Zfish   657 RREIR-SDGRVVRT-EQGLLLRSLQLSDSGVYQCTSTEKNFKHTLVKLQLVVLSAHTVNSIQTES 719

  Fly   722 ---CSPPSQKQDYQKIYSHWCNEFEKYKSAM 749
               .:||.|.       |.|....|:||..:
Zfish   720 GAPAAPPLQS-------SAWTPSAEQYKDLL 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	171/518 (33%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	25/97 (26%)
sema3fa	XP_005166096.1	Sema_3F	59..558	CDD:200515	172/535 (32%)
		PSI	557..594	CDD:214655	11/38 (29%)
		Ig_Semaphorin_classIII	619..709	CDD:143279	25/96 (26%)
		IG_like	623..698	CDD:214653	21/81 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.910