Protein Alignment Sema2b and Sema2a

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Alignment Length: 723
• Identity: 489/723 - (67%)
• Similarity: 598/723 - (82%)
• Gaps: 8/723 - (1%)

  Fly    59 LCSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAA--HHLRHHKEHVQDFSCGPLH 121
            |..||.||.:|:.....|....||||||||.|||.|||||:...  ::.:|..:||::|:||.|:
  Fly     3 LLQLSPLLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADHVREFNCGKLY 67

  Fly   122 YKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVECRNH 186
            |:||:|:|..:.||||||||:||:||:|||.|.|.|||:.||||..|:::||||||.:..:|:||
  Fly    68 YRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCKNH 132

  Fly   187 IRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYV 251
            :||||.|: .|.:||||||||||||||||.|||||||||:||.|:||||.||||||.|||||:||
  Fly   133 VRVIQSMD-QGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCPYDPLDNSTAIYV 196

  Fly   252 ENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEI 316
            |||||.|||.||:||||||||||:||||:||||.:..|.|..||||:|||||.||||||||||:|
  Fly   197 ENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDI 261

  Fly   317 GEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFN 381
            ||:|||||||.||||||||||||||:|||||.|.|||.:::.|||||||||:|||||.|||||||
  Fly   262 GEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGEFPFYFN 326

  Fly   382 EIQSVYKMPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKV 446
            ||||||::|:|.::|:|||||:|||||||||||:.|.:|.|||:||||||::|||||||||||:|
  Fly   327 EIQSVYQLPSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRV 391

  Fly   447 PEPRPGTCHNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQE 511
            ||||||||.|||:.|||:||||||.||||||||:||..|||::|||::.|||||||||||.||||
  Fly   392 PEPRPGTCVNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIRIDILNQE 456

  Fly   512 FLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQI 576
            ::||:|.|..|.||||||:...|:..|.|:||||.:| :|.|:.|.:|....|||:.|||::|||
  Fly   457 YIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAP-NEAIQVMEISQTRKSLYIGTDHRIKQI 520

  Fly   577 DIAMCARRYDSCFRCVSDPYCGWDKDVNACRPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQT 641
            |:|||.||||:|||||.||||||||:.|.||||:|.||||||||||.|||:|||:||:..:|||:
  Fly   521 DLAMCNRRYDNCFRCVRDPYCGWDKEANTCRPYELDLLQDVANETSDICDSSVLKKKIVVTYGQS 585

  Fly   642 LHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLD 706
            :||.||||:||||:.:|..|||||.:|||||:||:|||||:|.|.|||:::|||.||||||.:|.
  Fly   586 VHLGCFVKIPEVLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDCHLG 650

  Fly   707 GTLLCSYGVTVDAHRCSPPSQKQDYQKIYSHWCNEFEKYKSAMKQWQAKQEQCGLKDKTGPISSN 771
            |:|||||.:|||||||:||::..|||||||.||:||||||:|||.|:.||.||..:..   .|||
  Fly   651 GSLLCSYNITVDAHRCTPPNKSNDYQKIYSDWCHEFEKYKTAMKSWEKKQAQCSTRQN---FSSN 712

  Fly   772 GKHVNDVF 779
             :|.|::|
  Fly   713 -QHPNEIF 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	326/458 (71%)
		PSI	583..>606	CDD:396154	18/22 (82%)
		Ig	632..724	CDD:472250	61/91 (67%)
		Ig strand B	642..646	CDD:409353	2/3 (67%)
		Ig strand C	658..662	CDD:409353	1/3 (33%)
		Ig strand E	686..690	CDD:409353	2/3 (67%)
		Ig strand F	700..705	CDD:409353	3/4 (75%)
		Ig strand G	717..720	CDD:409353	2/2 (100%)
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	326/458 (71%)
		PSI	527..>550	CDD:396154	18/22 (82%)
		Ig_Semaphorin_C	573..668	CDD:409368	63/94 (67%)
		Ig strand A	573..579	CDD:409368	4/5 (80%)
		Ig strand B	583..591	CDD:409368	4/7 (57%)
		Ig strand C	601..607	CDD:409368	2/5 (40%)
		Ig strand C'	609..612	CDD:409368	1/2 (50%)
		Ig strand D	622..626	CDD:409368	3/3 (100%)
		Ig strand E	630..637	CDD:409368	3/6 (50%)
		Ig strand F	643..652	CDD:409368	5/8 (63%)
		Ig strand G	655..668	CDD:409368	10/12 (83%)