Protein Alignment Sema2b and Sema3b

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_001073411.1
• Gene: Sema3b / 363142
• RGDID: 1310079
• Length: 749
• Species: Rattus norvegicus
• Alignment Length: 695
• Identity: 197/695 - (28%)
• Similarity: 301/695 - (43%)
• Gaps: 113/695 - (16%)

  Fly   122 YKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDIL-NCVSKGKREKVECRN 185
            |:...:||....|:|||.:.:..|:|.|||    :|...:..|...:.. .|...||....||.|
  Rat    55 YEALLVDEERGRLFVGAENHVASLSLDNIS----KRAKKLAWPAPVEWREECNWAGKDIGTECMN 115

  Fly   186 HIRVIQPMNFNGQKLYVCGTNAHNP-----------KDYVINANLTHLPRSQYVPGIGLGIGKCP 239
            .::::..  :|...|..|||.|.:|           ::.::..:|..|..         |.||.|
  Rat   116 FVKLLHA--YNHTHLLACGTGAFHPTCAFVEVGHRLEEPMLRLDLRKLED---------GKGKSP 169

  Fly   240 YDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKL 304
            |||...:.:|.|..       .||:|..|:....|..||||...|.:        .||..:||:.
  Rat   170 YDPRHRAASVLVGE-------ELYSGVAADLMGRDFTIFRSLGQNPS--------LRTEPHDSRW 219

  Fly   305 LDKPNFVGSFEIGEF-------VYFFFREHAVEYINC-GKAVYSRVARVCKNDRGGKYMISQNWA 361
            |::|.||..|.|.|.       :||||||.|||.... |:...|||.::|:||.||:..:...|.
  Rat   220 LNEPKFVKVFWIPESENPDDDKIYFFFRESAVEAAPAMGRMTVSRVGQICRNDLGGQRSLVNKWT 284

  Fly   362 TYLKARMNCSISS-EFPFYFNEIQSVYKMPTDD--TKF-YATFTTNTNGLIGSAVCSYDIRDINA 422
            |:||||:.||:.. |...:|:::|.|:.:.:.|  |.| ||.|:|::....|||||.|.:.|:..
  Rat   285 TFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDRQTPFLYAVFSTSSGIFQGSAVCVYSMNDVRR 349

  Fly   423 AFDGKFKEQATSNSAWLPVLNSKVPEPRPGTC-------HNDTATLPDSVLNFIRKHPLMDKAVD 480
            ||.|.|..:......|:. ...:||.||||.|       .:.|...||.|:.|.|.||||..:|.
  Rat   350 AFLGPFAHKEGPTHQWVS-YQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVL 413

  Fly   481 HEFGNPVFFK--RDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSN---L 540
            ...|.|:|.:  .....|::..|  |:...:..:.|.|:.|..|.:.|::. :..|.|.::   |
  Rat   414 PMGGRPLFLQVGAGYTFTQIAAD--RVAAADGHYDVLFIGTDVGTVLKVIS-VPKGSRPNSEGLL 475

  Fly   541 VDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRC--VSDPYCGWDKDV 603
            ::..:....|..|..|.:|.|...||:|:...|.||.:..|.....:|..|  ..||||.||.
  Rat   476 LEELQVFEDSAAITSMQISSKRHQLYIASPSAVAQIALHRCPALGRACAECCLARDPYCAWDG-- 538

  Fly   604 NACRPYQLGL-----LQDVAN-ETSGIC--DTS---VLRKKVTSSYGQTLHLSCFVKMPEVLRKK 657
            :||..:|...     .||:.| ..|.:|  |.|   :|.:||......:..|.|   .|..|:..
  Rat   539 SACTRFQPTAKRRFRRQDIRNGNPSTLCSGDPSHSVLLERKVLGVERGSAFLEC---EPRSLQAH 600

  Fly   658 QTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLCSYGVTVDAHRC 722
            ....:|.:.|....:|  ...:.::....||:|..:...|.|.|        ||   |.|:
  Rat   601 VEWTFHRAGEAAHTQV--LAEERVERTARGLLLRGLRRQDSGVY--------LC---VAVE---- 648

  Fly   723 SPPSQKQDYQKIYSHWCNEFEKYKSAMKQWQAKQEQCGLKDKTGP 767
              ....|..:::..|      ...:|..:..|:.|:..:....||
  Rat   649 --QGFSQPLRRLVLH------VLSAAQAERLARAEEAAVPAPPGP 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	151/492 (31%)
		PSI	583..>606	CDD:396154	8/24 (33%)
		Ig	632..724	CDD:472250	19/91 (21%)
		Ig strand B	642..646	CDD:409353	1/3 (33%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353	2/3 (67%)
		Ig strand F	700..705	CDD:409353	1/4 (25%)
		Ig strand G	717..720	CDD:409353	1/2 (50%)
Sema3b	NP_001073411.1	Sema	46..516	CDD:472829	151/494 (31%)
		PSI	515..>551	CDD:214655	12/37 (32%)
		Ig	575..665	CDD:472250	22/117 (19%)
		Ig strand B	588..592	CDD:409353	1/3 (33%)
		Ig strand C	600..604	CDD:409353	0/3 (0%)
		Ig strand E	627..631	CDD:409353	2/3 (67%)
		Ig strand F	641..646	CDD:409353	3/15 (20%)
		Ig strand G	658..661	CDD:409353	0/2 (0%)