DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and Sema1a

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster

Alignment Length:	634	Identity:	224/634 - (35%)
Similarity:	310/634 - (48%)	Gaps:	106/634 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 ATGKG---KHRL--------CSLSALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHH 104
            ||.|.   ||:|        ..:..||.|||...          ::.|.....|...........
  Fly    30 ATAKATIMKHKLSKFYGYGWMQVFLLLTVLVIGN----------QSAWQENIRPKLYVELGPEDV 84

  Fly   105 LRH-HKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSD 168
            |:. ..|.|.|      |:|....|  .|:|.:||.:.:|.|::.:    :.|:..|:......|
  Fly    85 LKFVGNESVVD------HFKLVTKD--GNSLLIGARNTVFNLSIHD----LVEQQRLVWTSPEDD 137

  Fly   169 ILNCVSKGKREKVECRNHIRV-IQPMNFNGQKLYVCGTNAHNP--KDYVI---NANLTHLPRSQY 227
            ...|:.|||.|:. |:|:||: :.|   :..:|:|||||:..|  ..|:|   |..|......|.
  Fly   138 TKMCLVKGKDEEA-CQNYIRIMVVP---SPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQA 198

  Fly   228 VPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEA 292
            |         |||||..|||:|..:|       .||:||.|:|:.:|.:|:|..|
  Fly   199 V---------CPYDPRHNSTSVLADN-------ELYSGTVADFSGSDPIIYREPL---------- 237

  Fly   293 NFKRTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMIS 357
               :|.:|||..|:.||||.||..|:||||||||.|||:||||||:|||||||||.|:||.:...
  Fly   238 ---QTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFR 299

  Fly   358 QNWATYLKARMNCSISSEFPFYFNEIQSVYKM------PTDDTKFYATFTTNTNGLIGSAVCSYD 416
            ..|.::||:|:||||..::|||||||||...:      .......|..|.|.:|.:.|||||::.
  Fly   300 NRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFA 364

  Fly   417 IRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHNDTATLPDSVLNFIRKHPLMDKAVDH 481
            ::||...|:|:||||...||.||||.|:|||:||||:||||:..|||..||||:.|.|||:.|..
  Fly   365 LQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPDPTLNFIKTHSLMDENVPA 429

  Fly   482 EFGNPVFFKRDVI--LTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRH---SNLV 541
            .|..|:..:...|  .|::.||........:.:.|.||.|..|.|.|.|.........   |.::
  Fly   430 FFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVI 494

  Fly   542 DIFEASPHSEPIREMTL------------SHKTGSLYVATDHQVKQIDIAMCAR-RYDSCFRCVS 593
            :..:....|||||.:.:            |:..|.|.:.||.||..|.:..|.. :..||..||:
  Fly   495 EEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVA 559

  Fly   594 --DPYCGWDKDVNACRPY-------QLGLLQDVANETSGICDTSVLRKK 633
              ||||.|||....||.:       :....|:||......|.:..:..|
  Fly   560 LQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQHAACPSGKINSK 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	188/487 (39%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	1/2 (50%)
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	191/499 (38%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/33 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462129
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850