Protein Alignment Sema2b and Sema7a

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_001101623.1
• Gene: Sema7a / 315711
• RGDID: 1305192
• Length: 666
• Species: Rattus norvegicus
• Alignment Length: 696
• Identity: 171/696 - (24%)
• Similarity: 275/696 - (39%)
• Gaps: 162/696 - (23%)

  Fly    97 TGSSAAHHLR---------HHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNL---RN 149
            |.:||..|.|         ..::|| ||. .|..:...:.:..:.:::||...:::..|.   :|
  Rat    40 TAASAQGHSRSGPRISAVWKGQDHV-DFG-QPEPHNVLFHEPGSFSVWVGGRGKVYLFNFPEGKN 102

  Fly   150 ISQSICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYV 214
            .|    .|.|.|....||    |     ::|.:|.|:|.:::.   .|..|.||||||..|..:
  Rat   103 AS----VRTVNIGSTKGS----C-----QDKQDCENYITLLER---RGNGLLVCGTNARKPSCW- 150

  Fly   215 INANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFR 279
                  :|.....|..:|...|..|:.|.:||.                            |:|.
  Rat   151 ------NLVNDSVVMSLGEMKGYAPFSPDENSL----------------------------VLFE 181

  Fly   280 SDLYNLTNGRKEANFK----RTVKYDSKL------LDKPNFVGSFEI------GEFVYFFFREHA 328
            .|....|..::|.|.|    |.::.:|:|      :..|.|:.:..:      .:.:|:||||..
  Rat   182 GDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDN 246

  Fly   329 VEYINCGKAVYSRVARVCKNDRGGKYMIS-QNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTD 392
            .:.........||||::|:.|:||:..:| ..|.|:|||.:.|| .:.....||.:|.|:.:|..
  Rat   247 PDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCS-DAATNRNFNRLQDVFLLPDP 310

  Fly   393 -----DTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPG 452
                 ||:.|..|:...|   .||||.|.:.||:..|       .||:   |...:..:|.||||
  Rat   311 SGQWRDTRVYGVFSNPWN---YSAVCVYSLGDIDRVF-------RTSS---LKGYHMGLPNPRPG 362

  Fly   453 TCHNDTATLPDSVLNFIRKHPLMDKAVD--HEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVY 515
            .|......:|.........||.:.:.|:  .....|:|..: ....|:||.:::... .:.|.|.
  Rat   363 MCLPKKQPIPTETFQVADSHPEVAQRVEPMGPLKTPLFHSK-YHYQKVVVHRMQASN-GETFHVL 425

  Fly   516 FVATTSGHIYKIVQFMHYGQRHSNLVDIFEASP--HSEPIREMTLSHKTGSLYVATDHQVKQIDI 578
            ::.|..|.|:|:|:  ...|.||.:.:|.|..|  .:..|:.::|......|||.:..:|.|:.:
  Rat   426 YLTTDRGTIHKVVE--SGDQEHSFVFNIMEIQPFHRAAAIQAISLDADRRKLYVTSPWEVSQVPL 488

  Fly   579 AMCARRYDSCFRCV--SDPYCGWDKDVNAC---RPYQLGLLQDV-ANETSGIC-----DTSVLRK 632
            .||......|..|:  .|||||||:|.:.|   ...|..:||.: ..|....|     |.:.| :
  Rat   489 DMCGVYSGGCHGCLMSRDPYCGWDQDQDRCVSIYSSQRSVLQSINPAEPHRECPNPNPDEAPL-Q 552

  Fly   633 KVTSSYGQTLHLSCFVKMPEVLRKKQTRWYH-----HSTEKGRYEVRYTPTKYIDTNEGGLVLLA 692
            ||:.:.....:|:|    |...|.....|.|     .|.|.|              ::....:|.
  Rat   553 KVSLARNSRYYLTC----PMESRHATYLWRHEENVEQSCEPG--------------HQSPSCILF 599

  Fly   693 VNEGDGGRYDSYLDGTLLCSYGVTVDAHRCSPPSQKQDYQKIYSHW 738
            :......:|..|                ||.  :|:..|.....||
  Rat   600 IENLTARQYGHY----------------RCE--AQEGSYLHEAQHW 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	121/487 (25%)
		PSI	583..>606	CDD:396154	10/24 (42%)
		Ig	632..724	CDD:472250	16/96 (17%)
		Ig strand B	642..646	CDD:409353	1/3 (33%)
		Ig strand C	658..662	CDD:409353	0/3 (0%)
		Ig strand E	686..690	CDD:409353	0/3 (0%)
		Ig strand F	700..705	CDD:409353	1/4 (25%)
		Ig strand G	717..720	CDD:409353	0/2 (0%)
Sema7a	NP_001101623.1	Sema_7A	70..489	CDD:200504	121/487 (25%)
		PSI	491..542	CDD:396154	16/50 (32%)
		Ig	549..622	CDD:472250	19/109 (17%)
		Ig strand B	562..566	CDD:409353	1/3 (33%)
		Ig strand C	574..578	CDD:409353	0/3 (0%)
		Ig strand E	596..600	CDD:409353	1/3 (33%)
		Ig strand F	610..615	CDD:409353	3/22 (14%)