DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and Sema6d

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_038960912.1	Gene:	Sema6d / 311384	RGDID:	1310910	Length:	1086	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	230/745 - (30%)
Similarity:	344/745 - (46%)	Gaps:	142/745 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LLLVLVAQTVHVEYARADYE-NTWNLYY--EPPCCTGSSAAHHLRHHKEHVQDFSCGPLHYKTFY 126
            :|.:||::...|.:...|.. ||.:.:|  :.|...|..:.    :..:|..||.         .
  Rat    10 VLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSG----NESQHRLDFQ---------L 61

  Fly   127 MDERNNALYVGAMDRIFRLNLRNISQS-ICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVI 190
            |.:..:.||:...|:::.:||.:|.|: :.....|.......|..||..||| .|.||.|.|:|.
  Rat    62 MLKIRDTLYIAGRDQVYTVNLNDIPQTEVIPSKKLTWRSRQQDRENCAMKGK-HKDECHNFIKVF 125

  Fly   191 QPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGN 255
            .|.  |.:.::||||||.||.     .....|...:|......|:.:||:|....:.|::.:.
  Rat   126 VPR--NDEMVFVCGTNAFNPM-----CRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADG-- 181

  Fly   256 PFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFV 320
                 .||:.|.|:|..:|:||:||        ..:.:..||:|||||.:.:|:|:.:.|.|.:|
  Rat   182 -----KLYSATVADFLASDAVIYRS--------MGDGSALRTIKYDSKWIKEPHFLHAIEYGNYV 233

  Fly   321 YFFFREHAVEYINCGKAVYSRVARVCKNDRGG-KYMISQNWATYLKARMNCSISSEFPFYFNEIQ 384
            ||||||.|||:.|.||||||||||:||||.|| :.::.::|.::||||:|||:..:..|||:.:|
  Rat   234 YFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQ 298

  Fly   385 SVYK------MPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLN 443
            |:..      :||    ....|||..|.:.|||||::.:.||...|.|:||||.|.:|.|..|..
  Rat   299 SITDIIQINGIPT----VIGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPE 359

  Fly   444 SKVPEPRPGTC--------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDV--ILTKL 498
            .|||:||||.|        :..:...||..|:||:.|||||.||......|.|.|..|  .||.:
  Rat   360 DKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAI 424

  Fly   499 VVDKIRIDKLNQEFLVYFVATTSGHIYKIV-QFMHYGQRHSNLVDIFEA------SPHSEPIRE- 555
            .||  |.....|.:.|.||.:.:|.:.|:: :...:....|.|::..||      |..||..|:
  Rat   425 EVD--RSAGPYQNYTVIFVGSEAGVVLKVLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKV 487

  Fly   556 --MTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR-CVS--DPYCGWDKDVNACRPYQLGLL- 614
              :.|.....:||||....|.:|.::.| .||.||.: |::  |||||| .....|....||:|
  Rat   488 VSLQLDRDHHALYVAFSSCVVRIPLSRC-ERYGSCKKSCIASRDPYCGW-LSQGVCERVTLGMLL 550

  Fly   615 --QD---VANETSGICDTSVLRKKVTSSYGQTLHL-SCFVKM----------------------- 650
              :|   ..|.::|..:..       :.||.|.|| .|...:
  Rat   551 LTEDFFAFHNHSAGGYEQD-------TEYGNTAHLGDCHESLPTSTTPDYKIFGGPTSDMEVPSS 608

  Fly   651 --------PEVLRKKQTRWYHHSTEKGRYEVRYTP--TKYIDTNEG---GLVLLAVNEGDGGR-- 700
                    ||:..|....|....|...::.|:..|  :.:.||..|   | |...|..||..:
  Rat   609 SVTTVASSPEITSKVIDTWRPKLTSSRKFVVQDDPNTSDFTDTISGIPKG-VRWEVQSGDSNQMV 672

  Fly   701 ---------YDSYLDGTLLCSYGVTVDAHR 721
                     :.:::.|..:.  ||.|..:|
  Rat   673 HMNVLITCVFAAFVLGAFIA--GVAVYCYR 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	172/486 (35%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	25/135 (19%)
Sema6d	XP_038960912.1	Sema	49..513	CDD:417757	175/505 (35%)
Sema6d	XP_038960912.1	PSI	514..>543	CDD:396154	13/30 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910