DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2b and Sema5a

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_001101129.1	Gene:	Sema5a / 310207	RGDID:	1308650	Length:	1074	Species:	Rattus norvegicus

Alignment Length:	798	Identity:	236/798 - (29%)
Similarity:	338/798 - (42%)	Gaps:	190/798 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 WNL----YYEPPCCTGSSAAHHLRHHKE---HVQDFSC-GPLHYKTFYMDERNNALYVGAMDRIF 143
            |.|    ..:|..|  ..|.|.:..:||   .:::|.. ..:.:.....|.....|.|||.:.:|
  Rat    17 WRLARPETQDPAKC--QRAEHPVVSYKEIGPWLREFRAENAVDFSRLTFDPGQKELVVGARNYLF 79

  Fly   144 RLNLRNIS--QSI---CERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVC 203
            ||.|.::|  |::   |:      |.|..   .|.|||| .|.||:|:|||:.   ..|.:|:.|
  Rat    80 RLQLEDLSLIQAVQWECD------EATKK---ACYSKGK-SKEECQNYIRVLL---VGGDRLFTC 131

  Fly   204 GTNAHNPKDYVIN-ANLTHLPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTN 267
            ||||..|...:.: :|||.: ..|.     .|:.:|||.|..||||:...:|.      |||.|.
  Rat   132 GTNAFTPVCTIRSLSNLTEI-HDQI-----SGMARCPYSPQHNSTALLTASGE------LYAATA 184

  Fly   268 AEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEFVYFFFREHAVEYI 332
            .:|...|..|:|| |..|..       .||.:|:||.|::||||.|::||.|.||||||:|||:
  Rat   185 MDFPGRDPAIYRS-LGTLPP-------LRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH- 240

  Fly   333 NCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTDDTKFY 397
            :|||.|:||.|||||||.||::::...|.|::|||:|||...|.|||:||:||.:.:|..|. .|
  Rat   241 DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELDL-IY 304

  Fly   398 ATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRP----GTCHNDT 458
            ..||||.|.:..||||.:::..|:.||:|.||.|..|.|||||     .|.|.|    ||.....
  Rat   305 GIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLP-----YPNPNPNFQCGTMDQGL 364

  Fly   459 -ATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVY--FVATT 520
             ..|.:..|...:|..||.:.|......|.|.:.:...:.:.||.::    .::.||:  ::||.
  Rat   365 YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQ----GRDTLVHIIYLATD 425

  Fly   521 SGHIYKIVQFMHYGQRHSNLVDIFEASPH--SEPIREMTLSHKTGSLYVATDHQVKQIDIAMCAR 583
            .|.|.|:...:.... .|.|::..|..|.  |||||.:.:.|....|:|.....|.:|.:..| .
  Rat   426 YGTIKKVRAPLSQSS-GSCLLEEIELFPERKSEPIRSLKILHSQSVLFVGLQEHVVKIPLKRC-H 488

  Fly   584 RYDSCFRCV--SDPYCGWDKDVNACRPYQLGLLQDVANETSGICDTSVLRKKVTSSYGQTLHLSC 646
            .:.:...|:  .|||||||..:..|...:..|.....:::...|.|..|  .|..|:|.
  Rat   489 FHQTRGACIGAQDPYCGWDAVMKKCTSLEESLSMTQWDQSVPTCPTRNL--TVDGSFGP------ 545

  Fly   647 FVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGD-------------- 697
                          |           ..:||..:.|....|..|......|
  Rat   546 --------------W-----------SPWTPCTHTDGTAVGSCLCRSRSCDSPAPQCGGWQCEGP 585

  Fly   698 ----------GG--RYDSYLDGTLLCSYGVTVDAHRCSPPSQK--------QDYQKIYSHWCNEF 742
                      ||  .:.|:...:..|..|..|....||.|:.:        |:.::.|   |||.
  Rat   586 RMEITNCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERY---CNEH 647

  Fly   743 -----EKYKSAMKQWQAKQEQCG---------------------------------LKDKTGP-- 767
                 ..:.:....|:....|||                                 || ||.|
  Rat   648 LLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCENGPDCAGCNVEYQPCNTNACPELK-KTTPWT 711

  Fly   768 ------ISSNGKHVNDVF 779
                  ||.||.|....|
  Rat   712 PWTPVNISDNGGHYEQRF 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	174/473 (37%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	16/113 (14%)
Sema5a	NP_001101129.1	Sema_5A	50..485	CDD:200524	175/479 (37%)
		PSI	486..533	CDD:279745	11/47 (23%)
		TSP1	544..595	CDD:214559	8/81 (10%)
		TSP1	598..651	CDD:214559	12/55 (22%)
		TSP1	656..702	CDD:214559	4/45 (9%)
		TSP1	787..839	CDD:214559
		TSP1	853..896	CDD:214559
		TSP1	899..940	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810