DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and Sema5b

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_038944267.1	Gene:	Sema5b / 303901	RGDID:	1308914	Length:	1093	Species:	Rattus norvegicus

Alignment Length:	762	Identity:	230/762 - (30%)
Similarity:	347/762 - (45%)	Gaps:	153/762 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ALLLVLVAQTVHVEYARADYENTWNLYYEPPCCTGSSAAHHLRHH--------KEHVQDFSC-GP 119
            ||.|:|.:.|:.:.:.....:.|.....|...||       .|.|        |..|.:|:. |.
  Rat     8 ALSLLLPSFTLLLSHLSTSQDITSEPSSEQQLCT-------RREHPIVAFEDLKPWVSNFTYPGV 65

  Fly   120 LHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPT----GSDI-LNCVSKGKRE 179
            ..:....:|...|.|.|||.:.:|||:|.|:|         :|:.|    ..|. .:|.||||.|
  Rat    66 RDFSQLALDPSRNQLIVGARNYLFRLSLANVS---------LLQATEWASSEDTRRSCQSKGKTE 121

  Fly   180 KVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPAD 244
            : ||:|::||   :..:|:|:::|||||.:|  ...:..:.:|.|:  :..|. |:.:|||||..
  Rat   122 E-ECQNYVRV---LIVSGRKVFMCGTNAFSP--VCSSRQVGNLSRA--IEKIN-GVARCPYDPRH 177

  Fly   245 NSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPN 309
            |||||....|.      |||.|..:|:..|..|:||    |.:|..    .||.:|:||.|::||
  Rat   178 NSTAVISSQGE------LYAATVIDFSGRDPAIYRS----LGSGPP----LRTAQYNSKWLNEPN 228

  Fly   310 FVGSFEIGEFVYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISS 374
            ||.:|:||.|.|||.||:|||: :||:.||||||||||||.||::::...|.|::|||:|||...
  Rat   229 FVAAFDIGLFAYFFLRENAVEH-DCGRTVYSRVARVCKNDVGGRFLLEDTWTTFMKARLNCSRPG 292

  Fly   375 EFPFYFNEIQSVYKMPTDDTKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWL 439
            |.|||:||:||.:.:|..|. .|..||||.|.:..||||::::..|:.||:|.|:.|....:|||
  Rat   293 EVPFYYNELQSAFHLPEQDL-IYGVFTTNVNSIAASAVCAFNLSAISKAFNGPFRYQENPRAAWL 356

  Fly   440 PVLNSKVPEPR------PGTCHNDTAT---LPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVIL 495
            |:.|   |.|.      |.|..|:..|   |.|:...|     ||.:||......|...:..|..
  Rat   357 PIAN---PIPNFQCGTLPETGPNENLTERSLQDAQRLF-----LMSEAVQPVTPEPCVTQDSVRF 413

  Fly   496 TKLVVDKIRI-DKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASP-HSEPIREMTL 558
            :.||||.::. |.|   :.|.::.|.||.|.|.:.......|...|.::....| ..||:|.:.:
  Rat   414 SHLVVDLVQAKDTL---YHVLYIGTESGTILKALSTASRSLRGCYLEELHVLPPGRLEPLRSLRI 475

  Fly   559 SHKTGSLYVATDHQVKQIDIAMCARRYDSCFRCVS--DPYCGWDKDVNACRPYQLGLLQDVANET 621
            .|...:|||....:|.::.:..|: .|.|...|:.  |||||||.....|     ..|:|.:|
  Rat   476 LHSARALYVGLSDRVLRVPLERCS-AYLSQGACLGARDPYCGWDGKRQLC-----STLEDSSN-- 532

  Fly   622 SGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYE--VRYTPTKYIDTN 684
                 .|:..:.:|         :|.|:              :.|..|.:.  ..:.|.:::|.:
  Rat   533 -----MSLWIQNIT---------ACPVR--------------NVTRDGGFGPWSPWKPCEHLDGD 569

  Fly   685 EGGLVLLAVNEGDGGR--------------------------YDSYLDGTLLCSYGVTVDAHRCS 723
            ..|..|......|..|                          :.|:...:..|..|..|....||
  Rat   570 NSGSCLCRARSCDSPRPRCGGLECLGPAIHIANCSRNGAWTAWSSWAQCSTSCGIGFQVRQRSCS 634

  Fly   724 PPSQKQD-----YQKIYSHWCNE-----FEKYKSAMKQWQAKQEQCG 760
            .|:.:..     .:.....:|||     ...:.::...|......||
  Rat   635 NPAPRHGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSSNCG 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	175/474 (37%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	15/115 (13%)
Sema5b	XP_038944267.1	Sema	60..496	CDD:417757	177/480 (37%)
		PSI	497..544	CDD:396154	17/68 (25%)
		TSP1	609..662	CDD:214559	10/52 (19%)
		TSP1	667..713	CDD:214559	3/15 (20%)
		TSP1	798..850	CDD:214559
		TSP1	855..907	CDD:214559
		TSP_1	911..952	CDD:417691
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810