DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema2b and sema3ab

DIOPT Version :10

Sequence 1:NP_001261024.1 Gene:Sema2b / 246538 FlyBaseID:FBgn0264273 Length:824 Species:Drosophila melanogaster
Sequence 2:NP_571136.1 Gene:sema3ab / 30267 ZFINID:ZDB-GENE-991209-6 Length:778 Species:Danio rerio


Alignment Length:633 Identity:201/633 - (31%)
Similarity:302/633 - (47%) Gaps:93/633 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 YKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDILNCVSKGKREKVECRNH 186
            |.||.:||....|:|||.|.:...||.:|:.   ::.::....:.|....|...||..:.||.|.
Zfish    58 YHTFLLDEERGRLFVGAKDHVLSFNLVDINM---DQQLISWPSSPSRRDECKWAGKDVQKECANF 119

  Fly   187 IRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRSQ---YVPGIGL--GIGKCPYDPADNS 246
            |:|:||  ||...||.|||.|.:|    :.|::....||:   :..|...  |.||.||||...:
Zfish   120 IKVLQP--FNQTHLYACGTGAFHP----VCAHVEVGKRSEDNTFRLGSSFENGRGKSPYDPKLQT 178

  Fly   247 TAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFV 311
            .::.::.       .|||||:|:|...|..|||      |.|:...  .||.::||:.|:.|.||
Zfish   179 ASMLIDG-------ELYAGTSADFMGRDFAIFR------TLGKHHP--IRTEQHDSRWLNDPRFV 228

  Fly   312 GSFEIGEF-------VYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMN 369
            ....|.|.       :|.||||:|::.....||.::|:.::||||.||...:...|.|:||||:.
Zfish   229 SVHLIPESDNAEDDKIYLFFRENAIDGEQISKATHARIGQLCKNDFGGHRSLVNKWTTFLKARLV 293

  Fly   370 CSIS--SEFPFYFNEIQSVYKMPTDDTK---FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFK 429
            ||:.  :....:|:|:|.|:.|.:.|.|   .||.|||::|...|||||.|.:.||...|.|.:.
Zfish   294 CSVPGLNGIDTHFDELQDVFLMSSKDPKNPIIYAVFTTSSNIFKGSAVCMYSMADIRRVFLGPYA 358

  Fly   430 EQATSNSAWLPVLNSKVPEPRPGTC-------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPV 487
            .:...|..|:|.|| :||.||||||       ...|...||.|:.|.|.||.|...|.....:|:
Zfish   359 HRDGPNYQWVPFLN-RVPYPRPGTCPSKTFDGFESTKDFPDDVITFARSHPAMYNPVFPINNHPI 422

  Fly   488 FFKRDV--ILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIF--EASP 548
            ..|.||  ..|::|||  |::..:.::.|.|:.|..|.:.|:|.... |..| :|.::.  |.:.
Zfish   423 IIKTDVDYQFTQIVVD--RVEAEDGQYDVMFIGTDMGTVLKVVSIPR-GTWH-DLEEVLLEEMTV 483

  Fly   549 HSEP--IREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRC--VSDPYCGWD--------- 600
            ..||  |..|.||.|...||:.:...|.|:.:..|.....:|..|  ..||||.||         
Zfish   484 FREPTAITAMELSTKQQQLYLGSAIGVSQMPLHRCDVYGKACAECCLARDPYCAWDGSQCSRYFP 548

  Fly   601 --------KDVNACRPY-QLGLLQ--DVANETSGICDTSVLRKKVTSSYGQTLHLSCFVKMPEVL 654
                    :|:....|. |...||  |.|:..:|:.|.:|...:.:||:     |.|..|....|
Zfish   549 TAKRRTRRQDIRNGDPLTQCSDLQHHDEADGEAGLLDKTVYGVENSSSF-----LECSPKSQRAL 608

  Fly   655 RKKQTRW-YHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRY 701
                ..| :....|..:.|:: :..:.:.| |.||::.::::.|.|.|
Zfish   609 ----IYWQFQRHGEDHKLEIK-SDERVLGT-EQGLLIRSLHQKDSGVY 650

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema2bNP_001261024.1 Sema_2A 120..579 CDD:200499 166/486 (34%)
PSI 583..>606 CDD:396154 9/41 (22%)
Ig 632..724 CDD:472250 16/71 (23%)
Ig strand B 642..646 CDD:409353 1/3 (33%)
Ig strand C 658..662 CDD:409353 1/4 (25%)
Ig strand E 686..690 CDD:409353 2/3 (67%)
Ig strand F 700..705 CDD:409353 1/2 (50%)
Ig strand G 717..720 CDD:409353
sema3abNP_571136.1 Sema 27..519 CDD:472829 166/489 (34%)
PSI 517..>553 CDD:214655 9/35 (26%)
Ig_Sema3 582..673 CDD:409455 19/80 (24%)
Ig strand A 582..588 CDD:409455 2/5 (40%)
Ig strand B 593..601 CDD:409455 3/12 (25%)
Ig strand C 607..613 CDD:409455 2/9 (22%)
Ig strand C' 615..618 CDD:409455 0/2 (0%)
Ig strand D 628..632 CDD:409455 0/3 (0%)
Ig strand E 635..642 CDD:409455 2/6 (33%)
Ig strand F 648..657 CDD:409455 2/3 (67%)
Ig strand G 660..673 CDD:409455
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 727..778
Blue background indicates that the domain is not in the aligned region.

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