DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and sema3aa

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_571135.1	Gene:	sema3aa / 30266	ZFINID:	ZDB-GENE-991209-3	Length:	860	Species:	Danio rerio

Alignment Length:	744	Identity:	205/744 - (27%)
Similarity:	316/744 - (42%)	Gaps:	145/744 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 YKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDV--LILEPTGSDILNCVSKGKREKVECR 184
            |.||.||.....|.|||.|.:|..:|.||:     |||  :....|.|....|...||..:.:|.
Zfish    57 YDTFLMDGERGRLLVGAEDHVFSFDLVNIN-----RDVKQIAWPATPSKRDECKWAGKDLRKDCS 116

  Fly   185 NHIRVIQPMNFNGQKLYVCGTNAHNP-----------KDYVINANLTHLPRSQYVPGIGLGIGKC 238
            |.:||:|  ::|...:|:|||.|.:|           :|.:...:..:...         |.||.
Zfish   117 NFVRVLQ--SYNQTHIYICGTGAFHPICSFLEMGKRAEDNIFRLDANYFEN---------GRGKS 170

  Fly   239 PYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSK 303
            ||||...|:::.::.       .||:||:|:|...|..|||      |.|....  .||.::||:
Zfish   171 PYDPKMQSSSLLLDG-------ELYSGTSADFMGRDFAIFR------TLGSHHP--IRTEQHDSR 220

  Fly   304 LLDKPNFVGSFEIGEF-------VYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWA 361
            .|::|.|:|...|.|.       ::.||:|:|::..:.|||..||:.::||||.||...:...|.
Zfish   221 WLNEPRFLGIHLIPESDNPEDDKIFLFFKENAMDGEHTGKATISRIGQLCKNDMGGHRSLVNKWT 285

  Fly   362 TYLKARMNCSIS--SEFPFYFNEIQSVYKMPTDDTK---FYATFTTNTNGLIGSAVCSYDIRDIN 421
            |:|||::.||:.  :....:|:|:|.|:.|...|.|   .||.|||::|...|||:|.|.:.||.
Zfish   286 TFLKAKLTCSVPGLNGIDTHFDELQDVFLMSAKDPKNPVIYAVFTTSSNIFRGSAICMYSMADIR 350

  Fly   422 AAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTC-------HNDTATLPDSVLNFIRKHPLMDKAV 479
            ..|.|.:..:...|..|:| ...:||.||||||       .:.|..|||.|:.|.|.||.|...|
Zfish   351 RVFLGPYAHRDGPNYQWVP-FQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARLHPAMYNPV 414

  Fly   480 DHEFGNPVFFKRDV--ILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVD 542
            ....|.|:..:.:|  ..|:||||  |::..:.::.|.|:.|..|.:.|:|............|.
Zfish   415 QPMGGKPIVVRTNVEYQFTQLVVD--RVEAEDGQYDVMFIGTDLGTVLKVVTIPRESWHDLEEVV 477

  Fly   543 IFEASPHSE--PIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRC--VSDPYCGWDKDV 603
            :.|.:...|  ||..|.||.|...||:.:|..:.|:.:..|.....:|..|  ..||||.||.
Zfish   478 LEEMTVFREPTPITAMELSTKQQQLYLGSDLGISQMPLHRCEVYGKACAECCLARDPYCAWDG-- 540

  Fly   604 NACRPY-----QLGLLQDVAN-ETSGICD-----------TSVLRKKVTSSYGQTLHLSCFVKMP 651
            ..|..|     :....||:.| :....|.           :||..:.|......::.|.|..|..
Zfish   541 TECSRYFPTAKRRTRRQDIRNGDPLSQCSDLHHNDDLEGYSSVEERSVYGVENSSMFLECSPKSQ 605

  Fly   652 EVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLC---SY 713
            ..|...|.:   ...::.::|:  ...:.:.....||::.::.:.|        .|..||   .:
Zfish   606 RALIYWQLQ---KPNDERKHEI--VIDERLSLTGQGLLIRSLTQAD--------SGVFLCHAVEH 657

  Fly   714 GVTVDAHRCS---PPSQK-----------------------QDYQKIYSH--------WCNEFEK 744
            |......|.:   .|||:                       :|:..:..|        :|....|
Zfish   658 GFIQPLRRINLQVIPSQRVGELLLRAGTNDKDPAPKHKLWYRDFMSLLEHPDLNSVDEFCERIWK 722

  Fly   745 YKSAMKQWQAKQEQCGLKDKTGPISSNGK 773
            .:...|..:|.:...|    ||....|.|
Zfish   723 REKKPKGKKAPKVNPG----TGVSIKNEK 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	159/492 (32%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	14/90 (16%)
sema3aa	NP_571135.1	Sema	26..519	CDD:301699	159/495 (32%)
		PSI	517..569	CDD:214655	14/53 (26%)
		Ig_Semaphorin_classIII	583..673	CDD:143279	16/102 (16%)
		IG_like	586..654	CDD:214653	13/80 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..860		7/27 (26%)
		DUF4887	<744..859	CDD:292845	2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9670
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920