Protein Alignment Sema2b and sema3d

DIOPT Version :10

• Sequence 1: NP_001261024.1
• Gene: Sema2b / 246538
• FlyBaseID: FBgn0264273
• Length: 824
• Species: Drosophila melanogaster
• Sequence 2: NP_571123.2
• Gene: sema3d / 30250
• ZFINID: ZDB-GENE-990715-2
• Length: 764
• Species: Danio rerio
• Alignment Length: 753
• Identity: 202/753 - (26%)
• Similarity: 324/753 - (43%)
• Gaps: 137/753 - (18%)

  Fly   108 HKEHVQDF--SCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSD-I 169
            |...|..|  |....|::|..:||..:.|.:||.|.::.|:..||:    :....:..|...| :
Zfish    58 HSRSVVPFTGSSEGQHFQTVLLDEERSRLLLGAKDHVYLLDPDNIN----KHPKKLSWPASRDRV 118

  Fly   170 LNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNP-------------KDYVINANLTH 221
            ..|:..||....||.|.|||:.  ::|...:|.|||.|.:|             :...:::|...
Zfish   119 EMCILAGKNPLTECANFIRVLH--SYNRTHVYACGTGAFHPTCAFLEIKGHKEDRWLQLHSNTME 181

  Fly   222 LPRSQYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLT 286
            ..|.           |||:||.....:|..:.       .|||||.::|...||...||     .
Zfish   182 SGRM-----------KCPFDPNQPFASVLTDQ-------YLYAGTASDFLGKDSTFTRS-----L 223

  Fly   287 NGRKEANFKRTVKYDSKLLDKPNFVGSFEIGEF-------VYFFFREHAVEYINCGKAVYSRVAR 344
            .......:.||...:...:::..|:.:..|.:.       :||||||.:.:.....|:|.|||||
Zfish   224 GPPPHQQYIRTDISEDYWINEGKFISAHPISDTYNPDDDKIYFFFREASRDGSTTDKSVLSRVAR 288

  Fly   345 VCKNDRGGKYMISQNWATYLKARMNCSISSE--FPFYFNEIQSVYKMPTDDTK---FYATFTTNT 404
            :|:||.||...::..|.|:||||:.|||...  ...:|:|:|.::.:|:.|.|   .|..|||.:
Zfish   289 ICRNDVGGLRSLTNKWTTFLKARLVCSIPGPDGVDTHFDELQDIFLLPSRDEKNPMVYGVFTTTS 353

  Fly   405 NGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHN--------DTATL 461
            :...|||||.|.:.||.|||:|.:..:...:..|:. ...::|.||||||.:        .|...
Zfish   354 SIFKGSAVCVYTMEDIRAAFNGPYAHKEGPDHRWVE-YEGRIPYPRPGTCPSRTYDPHIKTTKDF 417

  Fly   462 PDSVLNFIRKHPLMDKAVDHEFGNPVF--FKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSGHI 524
            ||.|::|||.||||.::|....|.|:|  ...:..||:::||::..:  :.::.|.|:.|..|.:
Zfish   418 PDEVISFIRLHPLMYQSVHPMTGRPIFTRINTEYRLTQIIVDRVAAE--DGQYAVMFLGTDMGSV 480

  Fly   525 YKIVQFMHYGQRHSNLV-DIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSC 588
            .|:|...........:: :..:...:..||..|.:|.|...|:|.....:.|:.:..|......|
Zfish   481 LKVVSITQENWSSEEIILEELQVFKNPSPILNMEVSSKQQQLFVGGSDGLVQVSLHRCHIYGQGC 545

  Fly   589 FRC--VSDPYCGWDKDVNACRPY-----QLGLLQDVAN-ETSGIC-DT-SVLRKKVTSS--YG-- 639
            ..|  ..||||.||.  ..|..|     :....||:.: :.|..| || .||.:.|...  ||
Zfish   546 AECCLARDPYCAWDG--TQCSRYIPASKRRARRQDIKHGDPSSHCWDTEDVLGRNVEEKVLYGVE 608

  Fly   640 -QTLHLSCFVKMPEVLRKKQTRWY------HHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGD 697
             .:..|.|..|..:.|    .||:      .|     |.|::  |.:.:...:.||::..:..||
Zfish   609 SNSSFLECVSKSQQAL----IRWFVLKPGVDH-----RQEIK--PDERVLITDRGLLIRWLQRGD 662

  Fly   698 GGRY-----DSYLDGTLL-CSYGV----TVDAHR------------CSPPSQKQDYQKIYSHWCN 740
            .|.|     :.....||| .|..:    .::||:            ..|..:.:||.::.|....
Zfish   663 AGSYFCTSQEHRFTRTLLHVSLHILDRGQINAHQPAIRESSENPAVTEPRQRYKDYLRMLSGPAR 727

  Fly   741 EFEKYKSAMKQWQAKQEQCGLKDKTGPISSNGKHVNDV 778
            ..::|...|...:.||:|.|          ..|||.::
Zfish   728 SLDEYCETMWHREKKQKQKG----------KWKHVQEL 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	141/495 (28%)
		PSI	583..>606	CDD:396154	8/24 (33%)
		Ig	632..724	CDD:472250	25/124 (20%)
		Ig strand B	642..646	CDD:409353	1/3 (33%)
		Ig strand C	658..662	CDD:409353	1/3 (33%)
		Ig strand E	686..690	CDD:409353	2/3 (67%)
		Ig strand F	700..705	CDD:409353	1/9 (11%)
		Ig strand G	717..720	CDD:409353	0/2 (0%)
sema3d	NP_571123.2	Sema_3D	65..538	CDD:200513	143/504 (28%)
		PSI	537..589	CDD:214655	14/53 (26%)
		Ig_Sema3	598..689	CDD:409455	23/101 (23%)
		Ig strand A	598..604	CDD:409455	1/5 (20%)
		Ig strand B	609..617	CDD:409455	1/7 (14%)
		Ig strand C	623..629	CDD:409455	3/9 (33%)
		Ig strand C'	631..634	CDD:409455	0/2 (0%)
		Ig strand D	644..648	CDD:409455	0/3 (0%)
		Ig strand E	651..658	CDD:409455	2/6 (33%)
		Ig strand F	664..673	CDD:409455	2/8 (25%)
		Ig strand G	676..689	CDD:409455	4/12 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	743..764		6/23 (26%)