DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2b and Sema3a

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_059006.1	Gene:	Sema3a / 29751	RGDID:	3657	Length:	772	Species:	Rattus norvegicus

Alignment Length:	812	Identity:	226/812 - (27%)
Similarity:	341/812 - (41%)	Gaps:	189/812 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 ARADYENTWNLYYEPPCCTGSSAAHHLR-HHKEHVQDFS-------CGPLHYKTFYMDERNNALY 135
            |||:|.|            |.:....|: .:||.::..:       .....|.||.:||..:.||
  Rat    18 ARANYAN------------GKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLY 70

  Fly   136 VGAMDRIFRLNLRNISQ--------SICERDVLILEPTGSDILNCVSKGKREKVECRNHIRVIQP 192
            |||.|.||..||.||..        |...||            .|...||....||.|.|:|::.
  Rat    71 VGAKDHIFSFNLVNIKDFQKIVWPVSYTRRD------------ECKWAGKDILKECANFIKVLKA 123

  Fly   193 MNFNGQKLYVCGTNA-----------HNPKDYVINANLTHLPRSQYVPGIGLGIGKCPYDPADNS 246
              :|...||.|||.|           |:|:|.:.....:|...         |.||.||||...:
  Rat   124 --YNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDSHFEN---------GRGKSPYDPKLLT 177

  Fly   247 TAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFV 311
            .::.::.       .||:||.|:|...|..|||      |.|....  .||.::||:.|:.|.|:
  Rat   178 ASLLIDG-------ELYSGTAADFMGRDFAIFR------TLGHHHP--IRTEQHDSRWLNDPRFI 227

  Fly   312 GSFEIGEF-------VYFFFREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMN 369
            .:..|.|.       |||||||:|::..:.|||.::|:.::||||.||...:...|.|:||||:.
  Rat   228 SAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLI 292

  Fly   370 CSI--SSEFPFYFNEIQSVYKMPTDDTK---FYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFK 429
            ||:  .:....:|:|:|.|:.|.:.|.|   .|..|||::|...|||||.|.:.|:...|.|.:.
  Rat   293 CSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYA 357

  Fly   430 EQATSNSAWLPVLNSKVPEPRPGTC-------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPV 487
            .:...|..|:| ...:||.||||||       .:.|..|||.|:.|.|.||.|...|......|:
  Rat   358 HRDGPNYQWVP-YQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPI 421

  Fly   488 FFKRDV--ILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLVDIFEASPHS 550
            ..|.||  ..|::|||  |:|..:.::.|.|:.|..|.:.|:|............|.:.|.:...
  Rat   422 MIKTDVNYQFTQIVVD--RVDAEDGQYDVMFIGTDVGTVLKVVSVPKETWHDLEEVLLEEMTVFR 484

  Fly   551 EP--IREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFRC--VSDPYCGWDKDVNACRPY-- 609
            ||  |..|.||.|...||:.:...|.|:.:..|.....:|..|  ..||||.||.  ::|..|
  Rat   485 EPTTISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDG--SSCSRYFP 547

  Fly   610 ---QLGLLQDVANETSGICDTSVLRKKVTSSYGQTL---------HLSCFVKMPEVLRKKQTRW- 661
               :....||:.| ...:...|.|:.. .:.:|.:|         :.|.|::.....::....|
  Rat   548 TAKRRTRRQDIRN-GDPLTHCSDLQHH-DNHHGHSLEERIIYGVENSSTFLECSPKSQRALVYWQ 610

  Fly   662 YHHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRYDSYLDGTLLC---SYG-------VT 716
            :....|..:.|:|.  ..:|...|.||:|.::.:.|.|.|        ||   .:|       ||
  Rat   611 FQRRNEDRKEEIRV--GDHIIRTEQGLLLRSLQKKDSGNY--------LCHAVEHGFMQTLLKVT 665

  Fly   717 VDA----------HR--------------CSPPSQK---QDYQKIYSH--------WCNEFEKYK 746
            ::.          |:              ...||||   :|:.::.:|        :|.:.
  Rat   666 LEVIDTEHLEELLHKDDDGDGSKTKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQV---- 726

  Fly   747 SAMKQWQAKQEQCGLKDKTGPISSN-GKHVND 777
                 |:..::|...:......||| .||:.:
  Rat   727 -----WKRDRKQRRQRPGHSQGSSNKWKHMQE 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	165/500 (33%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	21/117 (18%)
Sema3a	NP_059006.1	Sema_3A	26..518	CDD:200510	168/532 (32%)
		PSI	516..>552	CDD:214655	11/37 (30%)
		Ig_Sema3	580..671	CDD:409455	20/100 (20%)
		Ig strand B	594..598	CDD:409455	1/3 (33%)
		Ig strand C	606..610	CDD:409455	0/3 (0%)
		Ig strand E	633..637	CDD:409455	2/3 (67%)
		Ig strand F	647..652	CDD:409455	3/12 (25%)
		Ig strand G	664..667	CDD:409455	2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..698		1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	729..772		6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11361
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920