DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2b and Sema3c

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	XP_008760867.1	Gene:	Sema3c / 296787	RGDID:	1309343	Length:	760	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	218/800 - (27%)
Similarity:	330/800 - (41%)	Gaps:	179/800 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 CCTGSSAAH--------HLRHHK-------EHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFR 144
            |..|||...        .||..|       .|.|      |.|:...|||..:.:|||:.|.|..
  Rat    24 CVQGSSQPQARVYLTFDELRETKTSEYFSLSHQQ------LDYRILLMDEDQDRIYVGSKDHILS 82

  Fly   145 LNLRNISQSICERDVLILEPTGS-DILNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAH 208
            ||:.||||    ..:.:..|..: .:..|...||.....|.|.:||||  .||...|||||:.|.
  Rat    83 LNINNISQ----EPLSVFWPASTIKVEECKMAGKDPTHGCGNFVRVIQ--TFNRTHLYVCGSGAF 141

  Fly   209 NPKDYVINANLTHLPRSQYVPG--------IGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAG 265
            :|.       .|:|.|.:....        ...|.|:|.::|..|:.:|.:..       .|::|
  Rat   142 SPV-------CTYLNRGRRSEDQVFMIDSKCESGKGRCSFNPNVNTVSVMINE-------ELFSG 192

  Fly   266 TNAEFTKADSVIFRSDLYNLTNGRKEANFKRTVKYDSKLLDKPNFVGSFEIGE-------FVYFF 323
            ...:|...|:.||||    ||    :.|..||.:::||.|.:|.||.:..|.:       .||||
  Rat   193 MYIDFMGTDAAIFRS----LT----KRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFF 249

  Fly   324 FREHAVEYINCGKAVYSRVARVCKNDRGGKYMISQNWATYLKARMNCSISSEF--PFYFNEIQSV 386
            |:|...:.....|.::|.|||:|.||.||:..:...|.|:||||:.||::.|.  ..:|:|::.|
  Rat   250 FKERLTDNNRSTKQIHSMVARICPNDTGGQRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDV 314

  Fly   387 YKMPTDD---TKFYATFTTNTNGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPE 448
            :.:.||:   |..|..|||:::...|||||.|.:.||...|:|.|..:...|.. |.....::|.
  Rat   315 FLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQ-LISYQGRIPY 378

  Fly   449 PRPGTC--------HNDTATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFK--RDVILTKLVVDKI 503
            ||||||        ...|...||.|:.|||.||||..::......|:..:  .|...||:.||
  Rat   379 PRPGTCPGGAFTPNMRTTKDFPDDVVTFIRNHPLMYNSIYPIHRRPLIVRIGTDYKYTKIAVD-- 441

  Fly   504 RIDKLNQEFLVYFVATTSGHIYKIVQFMHYGQRHSNLV-DIFEASPHSEPIREMTLSHKTGSLYV 567
            |::..:..:.|.|:.|..|.:.|:|...........|: :..|...:..||..|.:|.|...|||
  Rat   442 RVNAADGRYHVLFLGTDRGTVQKVVVLPTNSSASGELILEELEVFKNHVPITTMKISSKKQQLYV 506

  Fly   568 ATDHQVKQIDIAMCARRYDSCFRC--VSDPYCGWD-----------------KDV------NACR 607
            :::..|.|:.:..|.....:|..|  ..||||.||                 :||      ..||
  Rat   507 SSNEGVSQVSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCR 571

  Fly   608 PYQLGLLQDVANETSGICDTSVLRKKVTSSYG---QTLHLSCFVKMPEVLRKKQTRWYHHSTEKG 669
            .:.|..::...|....:            .||   .:..|.|..|.|:.    ..:|.....:..
  Rat   572 GFNLKGMRAYRNAAEIV------------QYGVRNNSTFLECAPKSPQA----SIKWLLQKDKDR 620

  Fly   670 RYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRY------DSY------LDGTLLCSYGVTVDAHRC 722
            |.||:.. .:.|.|:: ||::.:|.:.|.|.|      :|:      ::..:|.|..|.|...:.
  Rat   621 RKEVKLN-ERIIATSQ-GLLIRSVQDSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDKW 683

  Fly   723 SP----------PSQKQDYQKIYSH--------WCNEFEKYKSAMKQWQAKQEQCGLKDKTGPIS 769
            ||          |...:|....:||        :|      |...:|.|..:|...::...|.:.
  Rat   684 SPWTWAGSVRALPFHPKDILGAFSHSEMQLINQYC------KDTRQQQQLGEEPQKMRGDYGKLK 742

  Fly   770 SNGKHVNDVFSNDALVXPRK 789
                         ||:..||
  Rat   743 -------------ALINSRK 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	155/490 (32%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	23/102 (23%)
Sema3c	XP_008760867.1	Sema_3C	51..520	CDD:200512	157/505 (31%)
		PSI	519..556	CDD:214655	9/36 (25%)
		Ig_Semaphorin_classIII	584..673	CDD:143279	20/106 (19%)
		IG_like	588..662	CDD:214653	19/91 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910