DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2b and Sema4g

DIOPT Version :9

Sequence 1:	NP_001261024.1	Gene:	Sema2b / 246538	FlyBaseID:	FBgn0264273	Length:	824	Species:	Drosophila melanogaster
Sequence 2:	NP_036106.1	Gene:	Sema4g / 26456	MGIID:	1347047	Length:	837	Species:	Mus musculus

Alignment Length:	693	Identity:	198/693 - (28%)
Similarity:	282/693 - (40%)	Gaps:	150/693 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LRHHKEHVQDFSCGPLHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPTGSDI 169
            :||.|...|       :|.|..::|.:..|.|||...:|.|:.|:|      ||     .|..:|
Mouse    46 IRHFKGQTQ-------NYSTLLLEEASERLLVGARGALFSLSARDI------RD-----RTHKEI 92

  Fly   170 ---------LNCVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPKDYVINANLTHLPRS 225
                     ..|..|||..:.||.||:|.:|  ..|....|.|||:|..|....|:|....||.|
Mouse    93 HWEASPEMQSKCHQKGKNNQTECFNHVRFLQ--RLNATHFYACGTHAFQPLCAAIDAETFILPTS 155

  Fly   226 QYVPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRK 290
                 ...|..|||||||...|.:.::.|       ||..|..||..... |.||         :
Mouse   156 -----FEEGKEKCPYDPARGFTGLIIDGG-------LYTATRYEFRSIPD-IRRS---------R 198

  Fly   291 EANFKRTVKYDSKLLDKPNFVGSFEIGEF----------VYFFF--REHAVEYINCGKAVY--SR 341
            ..:..||.:.....|:...||.|..:.|.          :||||  ||.........::.:  :|
Mouse   199 HPHSLRTEEAPMHWLNDAEFVFSVLVRESKTSAVGDDDKIYFFFMEREEGSSSFTQSRSSHRVAR 263

  Fly   342 VARVCKNDRGGKYMISQNWATYLKARMNCSISSEFPFYFNEIQSVYKMPTD---DTKFYATFTTN 403
            ||||||.|.|||.::.:.|.::||||:.|.|..     :..::.|..:..|   .|.|||.||..
Mouse   264 VARVCKGDLGGKKILQKKWTSFLKARLICHIPQ-----YETLRGVCSLNADTSSHTHFYAVFTLT 323

  Fly   404 T--NGLIGSAVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTC---------HND 457
            |  ..|..||:|.||:.:|.|.|.|.|.|.......| ......|||||||:|         :|.
Mouse   324 TQWKTLEASAICRYDLAEIQAVFTGPFMEYQDGARRW-GRYEGGVPEPRPGSCITDSLRSRGYNS 387

  Fly   458 TATLPDSVLNFIRKHPLMDKAVDHEFGNPVFFKRDVILTKLVVDKIRIDKLNQEFLVYFVATTSG 522
            :..||..||:|::.||||.:.|....|.|:..||:|..|.|....:. ......:.:.|:.|..|
Mouse   388 SQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNVRYTHLTGTHVS-TPAGPTYDLLFLGTADG 451

  Fly   523 HIYKIVQF---MHYGQRHSNLVDIFEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARR 584
            .|:|.|..   ||       :::..:.....:.:..:.:|....||||.....|.|..::.|: |
Mouse   452 WIHKAVVLGSGMH-------IIEEIQVFREPQSVDNLVISPMQHSLYVGAASGVLQFPLSSCS-R 508

  Fly   585 YDSCFRCV--SDPYCGWDKDVNACR-----PYQLGLLQDVANETSGICD-------------TSV 629
            |.||:.|:  .|||||||..::||.     ..:..|:||:.....| |:             .||
Mouse   509 YQSCYDCILARDPYCGWDSSIHACMVATTVANRTELIQDIERGNRG-CEGSRDAGPPPPLKTRSV 572

  Fly   630 LRKKVTSSYGQTLHLSCFVKMPEVLRKKQTRWYHHSTEKGRYEVRYTPTKYIDTNEG------GL 688
            ||       |..:.|.|  ..|..|.:  ..|..:.::           ...|..:|      ||
Mouse   573 LR-------GDDVLLPC--DQPSNLAR--ALWLLNGSK-----------SLSDGQDGYRVGVDGL 615

  Fly   689 VLLAVNEGDGGRYDSYLDGT----LLCSYGVTVDAHRCSPPSQ 727
            ::........|.|..|.:..    ||.||.:||.....:|..|
Mouse   616 LVTDTQLEHSGNYGCYAEENGLRMLLASYSLTVRPATPAPAPQ 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2b	NP_001261024.1	Sema_2A	120..579	CDD:200499	149/498 (30%)
Sema2b	NP_001261024.1	Ig	632..720	CDD:299845	19/97 (20%)
Sema4g	NP_036106.1	Sema	47..504	CDD:417757	153/512 (30%)
		PSI	505..555	CDD:396154	19/51 (37%)
		Ig_Sema4B_like	565..648	CDD:409456	21/104 (20%)
		Ig strand B	578..582	CDD:409456	1/3 (33%)
		Ig strand C	590..594	CDD:409456	0/5 (0%)
		Ig strand E	613..617	CDD:409456	2/3 (67%)
		Ig strand F	627..632	CDD:409456	1/4 (25%)
		Ig strand G	644..647	CDD:409456	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870