DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema2b and Sema3d

DIOPT Version :10

Sequence 1:NP_001261024.1 Gene:Sema2b / 246538 FlyBaseID:FBgn0264273 Length:824 Species:Drosophila melanogaster
Sequence 2:NP_001098103.1 Gene:Sema3d / 246262 RGDID:727939 Length:777 Species:Rattus norvegicus


Alignment Length:648 Identity:193/648 - (29%)
Similarity:306/648 - (47%) Gaps:87/648 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 HKEHVQDFSCGP-------LHYKTFYMDERNNALYVGAMDRIFRLNLRNISQSICERDVLILEPT 165
            :|:.:...:|.|       |.::|..:||....|.:||.|.:|.|||.:::::..:    |..|.
  Rat    49 YKDLLLSNTCIPFLGSSEGLDFQTLLLDEERGILLLGAKDHVFLLNLVDLNKNFKK----IYWPA 109

  Fly   166 GSDILN-CVSKGKREKVECRNHIRVIQPMNFNGQKLYVCGTNAHNPK-DYV-INANLTHLPRSQY 227
            ..:.:. |...||....||.|.|||:||  :|...:|||||.|.:|. .|: :.||...|.....
  Rat   110 AKERVELCKLAGKDANTECANFIRVLQP--YNKTHVYVCGTGAFHPLCGYIDLGANKEELIFKLD 172

  Fly   228 VPGIGLGIGKCPYDPADNSTAVYVENGNPFGLPALYAGTNAEFTKADSVIFRSDLYNLTNGRKEA 292
            :..:..|..|||:||.....:|..:.       .||:||.::|...|:...||     ....::.
  Rat   173 MQNLESGRLKCPFDPQQPFASVMTDE-------HLYSGTASDFLGKDTAFTRS-----LGLMQDH 225

  Fly   293 NFKRTVKYDSKLLDKPNFVGSFEI-------GEFVYFFFREHAVEYINCGKAVYSRVARVCKNDR 350
            ::.||...:...|:...|:|:|.|       .:.:||||||.:.|.....:::.|||.||||||.
  Rat   226 HYIRTDISEHYWLNGAKFIGTFPIPDTYNPDDDKIYFFFRESSQEGSTSDRSILSRVGRVCKNDV 290

  Fly   351 GGKYMISQNWATYLKARMNCSI--SSEFPFYFNEIQSVYKMPTDDTK---FYATFTTNTNGLIGS 410
            ||:..:...|.|:||||:.|||  |.....:|:|:|.:|.:||.|.:   .|..|||.::...||
  Rat   291 GGQRSLINKWTTFLKARLVCSIPGSDGADTHFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGS 355

  Fly   411 AVCSYDIRDINAAFDGKFKEQATSNSAWLPVLNSKVPEPRPGTCHN--------DTATLPDSVLN 467
            |||.|.:.||.|.|:|.:..:.:::..|:. .:.::|.||||||.:        .|...||.|::
  Rat   356 AVCVYSMADIRAVFNGPYAHKESADHRWVQ-YDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVIS 419

  Fly   468 FIRKHPLMDKAVDHEFGNPVFFKR---DVILTKLVVDKIRIDKLNQEFLVYFVATTSGHIYKIVQ 529
            |||:||:|.|:|....|.|. |||   |..||::|||.:..:  :.::.|.|:.|..|.:.|:|.
  Rat   420 FIRRHPVMYKSVYPVAGAPT-FKRINVDYRLTQIVVDHVVAE--DGQYDVMFLGTDIGTVLKVVS 481

  Fly   530 FMHYGQRHSNLVDI----FEASPHSEPIREMTLSHKTGSLYVATDHQVKQIDIAMCARRYDSCFR 590
            .   .:...|:.::    .:...|...|..|.||.|...|||.:...:.|:.:..|.....:|..
  Rat   482 I---SKEKWNMEEVVLEELQVFKHPTAILNMELSLKQQQLYVGSWDGLVQLSLHRCDTYGKACAD 543

  Fly   591 C--VSDPYCGWDKDVNACRPY-----QLGLLQDVA---------NETSGICDTSVLRKKVTSSYG 639
            |  ..||||.||.  |||..|     :....|||.         :....|...:...|.:.....
  Rat   544 CCLARDPYCAWDG--NACSRYAPTSKRRARRQDVKYGDPITQCWDIEDSISHEAADEKVIFGIEF 606

  Fly   640 QTLHLSCFVKMPEVLRKKQTRWY-HHSTEKGRYEVRYTPTKYIDTNEGGLVLLAVNEGDGGRY 701
            .:..|.|..|.    ::....|| ..|.::.|.|::  |.:.|...:.||::.::.:.|.|.|
  Rat   607 NSTFLECIPKS----QQASVEWYIQRSGDEHREELK--PDERIIKTDYGLLIRSLQKKDSGIY 663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema2bNP_001261024.1 Sema_2A 120..579 CDD:200499 157/488 (32%)
PSI 583..>606 CDD:396154 9/24 (38%)
Ig 632..724 CDD:472250 16/71 (23%)
Ig strand B 642..646 CDD:409353 1/3 (33%)
Ig strand C 658..662 CDD:409353 0/3 (0%)
Ig strand E 686..690 CDD:409353 2/3 (67%)
Ig strand F 700..705 CDD:409353 1/2 (50%)
Ig strand G 717..720 CDD:409353
Sema3dNP_001098103.1 Sema_3D 61..534 CDD:200513 157/497 (32%)
PSI 533..570 CDD:214655 13/38 (34%)
Ig_Sema3 595..686 CDD:409455 16/75 (21%)
Ig strand A 595..601 CDD:409455 1/5 (20%)
Ig strand B 606..614 CDD:409455 1/7 (14%)
Ig strand C 620..626 CDD:409455 1/5 (20%)
Ig strand C' 628..631 CDD:409455 1/2 (50%)
Ig strand D 641..645 CDD:409455 1/3 (33%)
Ig strand E 648..655 CDD:409455 2/6 (33%)
Ig strand F 661..670 CDD:409455 2/3 (67%)
Ig strand G 673..686 CDD:409455
Blue background indicates that the domain is not in the aligned region.

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